Propranolol for Kaposi Sarcoma
Trial Summary
What is the purpose of this trial?
Kaposi sarcoma (KS) lesions are initiated by endothelial cells infected with KS herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8). Lesion progression is driven by abnormal angiogenesis, chronic inflammation, and uncontrolled cell proliferation. KS remains one of the most commonly diagnosed cancers in many African countries where economic constraints prevent successful treatment in most patients. Treatment outcomes in developed countries are also often unsatisfactory in HIV positive patients despite good virological and immunological responses to antiretroviral therapy. Therefore, identification of new oral, safe treatment options for treatment of KS remains a research priority. Given the known anti-angiogenic properties and based on the treatment response with other benign vascular lesions such as infantile hemangioma, propranolol is a good candidate for the treatment of KS. The hypothesis of this study is that treating patients with Kaposi sarcoma with propranolol will result in an overall response rate (complete response rate plus partial response rate) of at least 45%, and that propranolol will be safe and well tolerated in this patient population.
Research Team
Lee Ratner, MD
Principal Investigator
Washington University School of Medicine
Eligibility Criteria
This trial is for adults with Kaposi Sarcoma, a cancer caused by the KS herpesvirus. It's looking for participants who need new treatment options, including those in countries with limited access to current treatments or HIV positive patients not responding well despite antiretroviral therapy.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Propranolol (Beta-blocker)
Propranolol is already approved in Canada for the following indications:
- Hypertension
- Angina pectoris
- Arrhythmias
- Migraine prophylaxis
- Essential tremor
- Anxiety
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor
David H. Perlmutter
Washington University School of Medicine
Chief Executive Officer since 2015
MD from Washington University School of Medicine
Paul Scheel
Washington University School of Medicine
Chief Medical Officer since 2022
MD from Washington University School of Medicine