Dr. Sameer Sheth, PhD, MD
Claim this profileBaylor College of Medicine
Studies Depression
Studies Obsessive-Compulsive Disorder
5 reported clinical trials
8 drugs studied
Affiliated Hospitals
Clinical Trials Sameer Sheth, PhD, MD is currently running
Deep Brain Stimulation
for Depression
The goal of the study is to address the unmet need of TRD patients by identifying brain networks critical for treating depression and to use next generation precision DBS with steering capability to engage these targeted networks. The study's goal will be achieved through 3 specific aims: 1. Demonstrate device capability to selectively and predictably engage distinct brain networks 2. Delineate depression-relevant networks and demonstrate behavioral changes with network-targeted stimulation 3. Demonstrate that chronic DBS using steered, individualized targeting is feasible and safe for reducing depressive symptoms
Recruiting1 award N/A13 criteria
Brain Activity Monitoring
for Epilepsy
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is human's ability to respond correctly to novel contextual situations on the first attempt, without prior rehearsal. The investigators refer to this ability as 'ad hoc self-programming': 'ad hoc' because these new behavioral repertoires are cobbled together on the fly, based on immediate demand, and then discarded when no longer necessary; 'self-programming' because the brain has to configure itself appropriately based on task demands and some combination of prior experience and/or instruction. The overall goal of our research effort is to understand the neurophysiological and computational basis for ad hoc self-programmed behavior. The previous U01 project (NS 108923) focused on how these programs of action are initially created. The results thus far have revealed tantalizing notions of how the brain represents these programs and navigates through the programs. In this proposal, therefore, the investigators focus on the question of how these mental programs are executed. Based on the preliminary findings and critical conceptual work, the investigators propose that the medial temporal lobe (MTL) and ventral prefrontal cortex (vPFC) creates representations of the critical elements of these mental programs, including concepts such as 'rules' and 'locations', to allow for effective navigation through the algorithm. These data suggest the existence of an 'algorithmic state space' represented in medial temporal and prefrontal regions. This proposal aims to understand the neurophysiological underpinnings of this algorithmic state space in humans. By studying humans, the investigators will profit from our species' powerful capacity for generalization to understand how such state spaces are constructed. The investigators therefore leverage the unique opportunities available in human neuroscience research to record from single cells and population-level signals, as well as to use intracranial stimulation for causal testing, to address this challenging problem. In Aim 1 the investigators study the basic representations of algorithmic state space using a novel behavioral task that requires the immediate formation of unique plans of action. Aim 2 directly compares representations of algorithmic state space to that of physical space by juxtaposing balanced versions of spatial and algorithmic tasks in a virtual reality (VR) environment. Finally, in Aim 3, the investigators test hypotheses regarding interactions between vPFC and MTL using intracranial stimulation.
Recruiting1 award N/A
More about Sameer Sheth, PhD, MD
Clinical Trial Related5 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Sameer Sheth, PhD, MD has experience with
- Directional Deep Brain Stimulation
- Commercially Available 8-contact Boston Scientific Leads
- Medtronic Percept RC Neurostimulator
- Novel 16-contact Boston Scientific Leads (total 64 Implanted DBS Contacts)
- BX Pulsar 1002
- EMU
Breakdown of trials Sameer Sheth, PhD, MD has run
Obsessive-Compulsive Disorder
Major Depressive Disorder
Obsessive Compulsive Personality Disorder
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Sameer Sheth, PhD, MD specialize in?
Sameer Sheth, PhD, MD focuses on Depression and Obsessive-Compulsive Disorder. In particular, much of their work with Depression has involved treating patients, or patients who are undergoing treatment.
Is Sameer Sheth, PhD, MD currently recruiting for clinical trials?
Yes, Sameer Sheth, PhD, MD is currently recruiting for 3 clinical trials in Houston Texas. If you're interested in participating, you should apply.
Are there any treatments that Sameer Sheth, PhD, MD has studied deeply?
Yes, Sameer Sheth, PhD, MD has studied treatments such as Directional Deep Brain Stimulation, Commercially available 8-contact Boston Scientific leads, Medtronic Percept RC neurostimulator.
What is the best way to schedule an appointment with Sameer Sheth, PhD, MD?
Apply for one of the trials that Sameer Sheth, PhD, MD is conducting.
What is the office address of Sameer Sheth, PhD, MD?
The office of Sameer Sheth, PhD, MD is located at: Baylor College of Medicine, Houston, Texas 77030 United States. This is the address for their practice at the Baylor College of Medicine.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.