Deep Brain Stimulation for Obsessive-Compulsive Disorder
(OBSESS Trial)

Recruiting in Palo Alto (17 mi)

+1 other location

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Baylor College of Medicine

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial tests deep brain stimulation (DBS) for patients with severe OCD who haven't improved with other treatments. DBS involves placing electrodes in the brain to send electrical signals to specific areas. The study aims to personalize these signals using advanced technology to improve treatment outcomes and make the therapy more accessible.

Eligibility Criteria

This trial is for adults aged 21-70 with severe OCD that hasn't improved after trying multiple treatments, including specific antipsychotics and SSRIs, clomipramine, and at least 20 sessions of cognitive-behavioral therapy. Participants must have a significant other to communicate with the research team if needed.

Inclusion Criteria

My depression, linked to my OCD, scores at least 16 on the HAM-D.

I have tried clomipramine without success.

I have had OCD for over 5 years that hasn't improved with treatment and significantly affects my daily life.

+8 more

Exclusion Criteria

I do not have Tourette's with tics as severe as my OCD symptoms.

Pregnant or plans to become pregnant in the next 24 months

Any psychiatric disorder that, in the opinion of the Scientific Steering Group, may interfere with the candidate's ability to participate in study activities

+8 more

Participant Groups

The OBSESS Trial is testing a Medtronic Percept RC neurostimulator device in patients with treatment-resistant OCD. It involves implanting DBS leads and temporary sEEG electrodes to personalize stimulation parameters aimed at reducing symptoms.

1Treatment groups

Experimental Treatment

Group I: Medtronic Percept RC neurostimulatorExperimental Treatment1 Intervention