Dr. Scott Irwin, MD, PhD

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Cedars-Sinai Health System

Studies Pancreatic Cancer
Studies Major Depressive Disorder
3 reported clinical trials
4 drugs studied

Area of expertise

1

Pancreatic Cancer

Scott Irwin, MD, PhD has run 2 trials for Pancreatic Cancer.

2

Major Depressive Disorder

Scott Irwin, MD, PhD has run 1 trial for Major Depressive Disorder. Some of their research focus areas include:

Stage I
Stage II
Stage III

Affiliated Hospitals

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Cedars-Sinai Health System

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Cedars-Sinai Medical Center

Clinical Trials Scott Irwin, MD, PhD is currently running

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Oral Ketamine

for Anxiety in Pancreatic Cancer Patients

This is a prospective, single center, double blind, randomized, crossover feasibility study of oral ketamine versus placebo for the treatment of anxiety in patients with pancreatic cancer currently receiving or within 12 weeks of receiving cancer targeted therapy. The primary objective is to determine the feasibility of enrolling subjects and treatment adherence. The secondary objectives are to describe the safety and tolerability. Exploratory objectives are to assess the effect of ketamine/placebo on Depression, Anxiety, Physical Function, Pain Interference, Pain Intensity, Fatigue, Sleep Disturbance, and Ability to Participate in Social Roles and Activities as measured by PROMIS Anxiety Short Form 7a and the PROMIS-29 Profile v2.1 of Patient Reported Outcomes, as well as changes in circulatory inflammatory cytokines, blood glutamine levels, and other biomarkers of anxiety and/or depression.

Recruiting

0 awards

Phase < 1

11 criteria

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Virtual Reality Therapy

for Gastrointestinal Cancer Pain

Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as well as health related quality of life (HRQOL). Therapeutic virtual reality (VR) has emerged as a promising and evidence-based treatment modality for cancer pain. Users of VR wear a pair of goggles with a close-proximity screen in front of the eyes that creates a sensation of being transported into lifelike, three-dimensional worlds. To date, VR has been limited to short-term clinical trials for cancer pain. Moreover, limited research exists on theory-based VR modalities beyond mere distraction, such as VR that employs acceptance and commitment therapy (ACT) with components of biofeedback and mindfulness. To bridge these gaps, this study seeks to: (1) assess the impact of immersive VR on patient-reported outcomes (PROs), including pain, activity metrics, and opioid use among patients with visceral pain from a digestive tract malignancy; (2) assess differences in PROs, activity metrics, and opioid use between skills-based VR therapy vs. distraction VR therapy; and (3) determine patient-level predictors of VR treatment response in visceral cancer pain. To address these aims, the study will measure PROs and opioid use in 360 patients randomized among 3 groups and follow them for 60 days after enrollment: (1) an enhanced VR group receiving skills-based VR; (2) a distraction-based VR group receiving patient-selected VR videos; and (3) a VR sham control group using a VR headset with 2-D content. The results will inform best practices for the implementation of VR for visceral cancer pain management and guide selection of patient-tailored experiences.

Recruiting

0 awards

N/A

4 criteria

More about Scott Irwin, MD, PhD

Clinical Trial Related

3 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Scott Irwin, MD, PhD has experience with

  • PDC-1421 Capsule
  • Virtual Reality
  • Ketamine
  • Placebo

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