Your session is about to expire
What is Biktarvy
BictegravirThe Generic name of this drug
Treatment SummaryTenofovir alafenamide is a medication used to treat chronic hepatitis B, HIV-1, and prevent HIV-1 infections. It is an improved version of its predecessor, tenofovir disoproxil, as it has a higher oral bioavailability and is better tolerated by the body. Tenofovir alafenamide is able to provide a high antiviral efficacy at much lower doses than tenofovir disoproxil. It was developed by Gilead Sciences Inc and approved by the FDA in 2015.
Biktarvyis the brand name
Biktarvy Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Biktarvy
Bictegravir
2018
4
Effectiveness
How Biktarvy Affects PatientsTenofovir alafenamide is an effective treatment for hepatitis B. It is much better on the kidneys than its counterpart, tenofovir disoproxil, and has been shown to be 5 times more powerful in its anti-HIV activity.
How Biktarvy works in the bodyTenofovir alafenamide is a drug that accumulates more in peripheral blood cells than it does in red blood cells. It then works to inhibit the replication of viruses, stopping them from reproducing and causing harm to cells. This is done by blocking their polymerase and preventing the synthesis of more viruses.
When to interrupt dosage
The prescribed dosage of Biktarvy is contingent upon the diagnosed circumstance, such as Treatment Naive, Chronic Hepatitis B and compensated liver disease. The quantity of dosage depends on the strategy of delivery as detailed in the table hereunder.Condition
Dosage
Administration
HIV
50.0 mg, , 30.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
treatment failure
50.0 mg, , 30.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Obesity
50.0 mg, , 30.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Anti-Retroviral Agents
50.0 mg, , 30.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Antiretroviral Treatment-Naïve
50.0 mg, , 30.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Biktarvy.Common Biktarvy Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Bictegravir.
Procainamide
Major
The excretion of Procainamide can be decreased when combined with Bictegravir.
Topotecan
Major
The excretion of Topotecan can be decreased when combined with Bictegravir.
Acyclovir
Minor
The excretion of Acyclovir can be decreased when combined with Bictegravir.
Cefradine
Minor
The excretion of Cefradine can be decreased when combined with Bictegravir.
Biktarvy Toxicity & Overdose RiskThe exact toxic dose of tenofovir alafenamide is unknown, so close monitoring of vital signs is necessary in cases of overdose. Tenofovir can be removed from the bloodstream by hemodialysis. Research has only been conducted on tenofovir disoproxil, which was reported to cause liver tumors in female mice that had long-term exposure to high doses. Tenofovir alafenamide has not been linked to any mutagenic effects and does not appear to harm fertility.
Biktarvy Novel Uses: Which Conditions Have a Clinical Trial Featuring Biktarvy?
55 active clinical trials are currently underway to investigate the potential of Biktarvy to treat conditions without necessitating CYP3A inhibitors, Chronic Hepatitis B and tenofovir.Condition
Clinical Trials
Trial Phases
HIV
40 Actively Recruiting
Phase 2, Phase 3, Early Phase 1, Not Applicable, Phase 1, Phase 4
Anti-Retroviral Agents
0 Actively Recruiting
treatment failure
0 Actively Recruiting
Antiretroviral Treatment-Naïve
0 Actively Recruiting
Obesity
0 Actively Recruiting
Biktarvy Reviews: What are patients saying about Biktarvy?
5Patient Review
11/8/2019 I started taking this two weeks ago with zero side effects. My D# was 402 and should be way above that soon. 11/8/19
5Patient Review
10/22/2018 I started taking biktarvy 1.5 months ago when I was diagnosed positive my viral load was 78600 copies and my CD4 was 60 I had another test a little over one month after I began taking biktarvy my viral load dropped to 80 copies and my CD4 went up to 346. I along with my doctor was amazed on how fast it reacted in my body I feel 100% better and put about 23 lbs on engery levels are back to normal and I have so far seen any side effects. I couldnâ??t be more happier of the results !
5Patient Review
5/4/2019 I was diagnosed with HIV and my viral load was incredibly high. My CD4 levels were also very low. I started taking this medication and it turned things around for me. It's been a life-saving treatment for sure.
5Patient Review
2/1/2019 Biktarvy has really helped me be able to eat and sleep better. It's great that I only have to take one pill a day too!
5Patient Review
12/15/2020 I've been managing my HIV diagnosis since 1991 and this is by far the best medication I've taken. No side effects whatsoever.
Patient Q&A Section about biktarvy
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the monthly cost of Biktarvy?
"BIKTARVY typically costs between $4 and $9 per month, although the list price is $3,584. Some state Medicaid programs offer even lower co-pays."
Answered by AI
Is Biktarvy a high risk medication?
"Biktarvy may have serious consequences, including lactic acidosis, liver problems, new or worsening kidney problems, and drug interactions."
Answered by AI
Does Biktarvy make you undetectable?
"If you are an adult who is replacing your current treatment with BIKTARVY, it can help you to stay undetectable and maintain your CD4 T-cell count. However, before taking BIKTARVY, you must meet certain requirements that your healthcare provider will determine."
Answered by AI
What is Biktarvy used for?
"BIKTARVY is a complete, 1-pill, once-a-day prescription medicine used to treat HIV-1 in certain adults that also comes with an important warning on hepatitis b infection. BIKTARVY does not cure HIV-1 or AIDS. HIV-1 is the virus that causes AIDS."
Answered by AI