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What is Phyllocontin
AminophyllineThe Generic name of this drug
Treatment SummaryAminophylline is a combination of two drugs, theophylline and ethylenediamine, that is used to treat lung diseases like asthma, chronic bronchitis, and COPD. The theophylline works by blocking certain enzymes and receptors in the body and activating histone deacetylases. Although aminophylline has been largely discontinued, some medications are still available but in limited supply.
Aminophyllineis the brand name
Phyllocontin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aminophylline
Aminophylline
1975
22
Effectiveness
How Phyllocontin Affects PatientsAminophylline is a form of theophylline that helps stimulate the central nervous system, skeletal muscles, and heart muscles. It also relaxes certain muscles in the lungs, increases urine production, and boosts the amount of acid produced in the stomach.
How Phyllocontin works in the bodyAminophylline is a medicine that contains theophylline, which can help relax the airways and blood vessels in your lungs. This helps people with breathing problems, like asthma. Theophylline works by blocking enzymes responsible for breaking down a molecule called cyclic AMP, which causes the airways to constrict. It also blocks adenosine molecules, which can cause bronchoconstriction. In inflammatory states, it can stop genes from being activated that lead to inflammation.
When to interrupt dosage
The measure of Phyllocontin is contingent upon the declared health issue, including Chronic Bronchitis, Lung Disorder and Bronchospasm. The amount of dosage is contingent upon the approach of delivery (e.g. Intravenous or Suppository) indicated in the table underneath.Condition
Dosage
Administration
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Bronchitis
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Bronchial Spasm
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Lung Diseases
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Bronchitis, Chronic
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Asthma
, 97.5 mg, 225.0 mg, 350.0 mg, 100.0 mg, 200.0 mg, 25.0 mg/mL, 105.0 mg/mL, 500.0 mg, 250.0 mg, 50.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Injection, solution, Injection, solution - Intravenous, Solution - Oral, Injection, Injection - Intravenous, Rectal, Suppository, Suppository - Rectal
Warnings
There are 20 known major drug interactions with Phyllocontin.Common Phyllocontin Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Aminophylline.
Amobarbital
Major
The therapeutic efficacy of Amobarbital can be decreased when used in combination with Aminophylline.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Aminophylline.
Barbexaclone
Major
The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Aminophylline.
Barbital
Major
The therapeutic efficacy of Barbital can be decreased when used in combination with Aminophylline.
Phyllocontin Novel Uses: Which Conditions Have a Clinical Trial Featuring Phyllocontin?
158 active studies are currently assessing the potential of Phyllocontin to provide relief for conditions like Bronchitis, Chronic Bronchitis and Asthma.Condition
Clinical Trials
Trial Phases
Bronchitis, Chronic
1 Actively Recruiting
Not Applicable
Asthma
104 Actively Recruiting
Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3, Phase 1
Bronchitis
6 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2
Bronchial Spasm
1 Actively Recruiting
Phase 2
Asthma
1 Actively Recruiting
Phase 4
Asthma
1 Actively Recruiting
Not Applicable
Lung Diseases
9 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Phyllocontin Reviews: What are patients saying about Phyllocontin?
5Patient Review
11/13/2015 Though it took a little over a year for this to start working for me, it has made an incredible difference that has improved my quality of life by 100%. I would highly recommend this drug to others, even though there are some risks associated with taking it.
5Patient Review
6/9/2020 Xolair has been an absolute godsend for me. I suffered from full-body hives for months before trying this, and it was honestly the only thing that worked. It took some time to start seeing results, but once it did, the difference was night and day. I highly recommend giving this a shot if you're struggling with chronic hives like I was.
5Patient Review
10/22/2015 I had my first Xolair injection 5 months ago and it has completely changed my life for the better. I haven't had a single hive since the treatment, which is amazing considering I've been suffering from chronic uticaria for over 7 years. The injections haven't been as costly as I was initially told, which is great. Overall, Xolair has changed my life for the better in so many ways.
5Patient Review
5/29/2019 This drug has been life-changing for me. I needed my Ventolin inhaler once a week before starting Xolair, and now 2 1/2 months in, I've only used about half of it. I'm more active than ever, and feeling great!
5Patient Review
7/3/2018 My blood test results improved after I started taking this medication, so my doctor in Nevada decided to take me off of it.
4.7Patient Review
6/17/2015 Xolair has been a complete game-changer for me. I've had asthma since I was two years old, and it used to flare up every evening no matter what medication or inhaler I was using. Xolair keeps me breathing freely and also helps with my seasonal allergies. It's not the most convenient treatment – I have to drive 30 minutes each way to get injections every two weeks – but it's worth it.
4.7Patient Review
2/16/2016 This injection has been a lifesaver for me. I've been taking it monthly for severe asthma for several years, and it's helped me immensely. I rarely need prednisone now, and while the injections can be a bit of a hassle to order and time, they're definitely worth it.
3.7Patient Review
8/16/2015 I've been having these injections for a little less than a year now, and at first they were great. But the last three times, I've had really severe asthma attacks the day after the injection that have taken weeks to recover from using Dacortin (prednisona). I'm going to talk to my consultant about it before getting the next injection. Has anyone else experienced this?
3Patient Review
10/26/2022 I took this medication because I am struggling with asthma and chronic urticaria. However, after the second day I started to experience chest tightness, diarrhea, and an increased heart rate. This was all very new to me as I've never tried this injection before.
2.7Patient Review
5/27/2019 The vial works great, but the pre-filled syringe is not very effective.
2.3Patient Review
3/2/2021 The price is outrageous. My daughter needs two injections per month, and they're each a thousand dollars. We just had sample shots; I don't know if it works yet.
2.3Patient Review
9/24/2015 I've had UCIs for about 10 years now, and no doctor has been able to tell me why. I was told that Xolair would be my cure, but after six shots, I'm still getting them just as frequently as before. Not only is this treatment ineffective, it's also very expensive.
Patient Q&A Section about phyllocontin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is there an alternative to Phyllocontin?
"If your doctor has prescribed Phyllocontin® for your asthma, they will contact you about your treatment options, which may include switching to Uniphyllin Continus, an alternative theophylline medication."
Answered by AI
Is Phyllocontin an aminophylline?
"Phyllocontin is a medication used to treat and prevent bronchospasm, a condition in which the airways of the lungs narrow. It is used in adults for the treatment and prevention of bronchospasm associated with conditions such as asthma, chronic obstructive pulmonary disease, and chronic bronchitis. For children, it is used to manage asthma."
Answered by AI
What is Phyllocontin used for?
"Aminophylline is an ingredient in these tablets that are used to treat asthma, long-term breathing difficulties, and sometimes heart failure in adults. These tablets belong to a group of medicines called bronchodilators."
Answered by AI
When was Phyllocontin discontinued?
"The Department of Health and Social Care announced on February 12th that Phyllocontin® will be discontinued in the UK. The stock of 225mg tablets is expected to be exhausted by 30th March 2021 and the 350mg tablets is expected to be exhausted by 5th April 2021."
Answered by AI