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What is Rybelsus
SemaglutideThe Generic name of this drug
Treatment SummarySemaglutide is a medication used to treat type 2 diabetes. It belongs to a class of drugs called glucagon-like peptide 1 (GLP-1) analogs. It was approved by the FDA in 2017 and can be injected once a week or taken as a tablet once a day. Semaglutide activates the GLP-1 receptor, which stimulates insulin secretion and lowers blood glucose levels. It has been shown to reduce HbA1c levels and body weight in people with type 2 diabetes. In 2021, it was also approved for chronic weight management in adults with general obesity or overweight.
Ozempicis the brand name
Rybelsus Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ozempic
Semaglutide
2017
19
Approved as Treatment by the FDA
Semaglutide, commonly known as Ozempic, is approved by the FDA for 5 uses including Type 2 Diabetes and Cardiovascular Events .Type 2 Diabetes
Cardiovascular Events
Cardiovascular Diseases
Physical Activity
Used in combination with other therapies
Diet
Used in combination with other therapies
Effectiveness
How Rybelsus Affects PatientsSemaglutide helps reduce levels of sugar in the blood, lower blood pressure, and cause weight loss. It does this by increasing insulin production and decreasing the amount of the hormone glucagon, which is usually linked to higher blood sugar levels. Semaglutide also decreases the amount of bad cholesterol and triglycerides in the body. However, it can cause medullary thyroid cell carcinoma in rodents, so those with a family history should not take this drug. It can also lead to pancreatitis, dehydration, and slower digestion, so patients should make sure to stay hydrated and be aware of the effects of other drugs
How Rybelsus works in the bodySemaglutide helps to control blood sugar by stimulating the pancreas to produce insulin and reducing the amount of glucagon, a hormone that raises blood sugar. It binds to the GLP-1 receptor and triggers other effects that help lower blood sugar. It also helps reduce the progression of atherosclerosis and can lead to weight loss by decreasing appetite and cravings.
When to interrupt dosage
The quantity of Rybelsus is contingent upon the determined condition, including Type 2 Diabetes, at least one weight-related comorbidity and reduced-calorie diet. The extent of dosage is subject to the mode of delivery (e.g. Solution - Subcutaneous or Subcutaneous) as noted in the table below.Condition
Dosage
Administration
Obesity
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Physical Activity
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Type 2 Diabetes
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Diet
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Chronic Weight Management therapy
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Cardiovascular Diseases
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Caloric Restriction
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
at least one weight-related comorbid condition
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Cardiovascular Events
, 1.34 mg/mL, 1.0 mg, 3.0 mg, 7.0 mg, 14.0 mg, 0.5 mg, 0.25 mg, 1.0 mg/pump actuation, 5.0 mg/mL, 2.5 mg/mL, 24.0 mg/mL, 10.0 mg/mL, 17.0 mg/mL, 2.68 mg/mL, 2.4 mg, 1.7 mg, 20.0 mg/mL
Solution, Solution - Subcutaneous, , Subcutaneous, Injection, solution, Injection, solution - Subcutaneous, Tablet - Oral, Tablet, Oral, Injection, powder, lyophilized, for suspension - Oral, Injection, powder, lyophilized, for suspension
Warnings
Rybelsus ContraindicationsCondition
Risk Level
Notes
Multiple Endocrine Neoplasia
Do Not Combine
Patient History of Medullary Thyroid Carcinoma
Do Not Combine
Medullary carcinoma of thyroid
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Semaglutide may interact with Pulse Frequency
Common Rybelsus Drug Interactions
Drug Name
Risk Level
Description
Acetohexamide
Moderate
Semaglutide may increase the hypoglycemic activities of Acetohexamide.
Carbutamide
Moderate
Semaglutide may increase the hypoglycemic activities of Carbutamide.
Chlorpropamide
Moderate
Semaglutide may increase the hypoglycemic activities of Chlorpropamide.
Englitazone
Moderate
The risk or severity of hypoglycemia can be increased when Semaglutide is combined with Englitazone.
Fluconazole
Moderate
The risk or severity of hypoglycemia can be increased when Semaglutide is combined with Fluconazole.
Rybelsus Toxicity & Overdose RiskPeople who take too much semaglutide (more than 4 mg in one dose) may experience nausea, although full recovery is expected. Patients should be monitored and given supportive care as needed, as the drug can remain in the body for up to one week. There is no specific antidote for an overdose of semaglutide.
Rybelsus Novel Uses: Which Conditions Have a Clinical Trial Featuring Rybelsus?
196 active studies are currently investigating the potential of Rybelsus to address Diseases and weight-related comorbidities, in individuals with a Body Mass Index >27 kg/m2.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
165 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Physical Activity
42 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Cardiovascular Events
5 Actively Recruiting
Not Applicable
at least one weight-related comorbid condition
0 Actively Recruiting
Cardiovascular Diseases
0 Actively Recruiting
Chronic Weight Management therapy
0 Actively Recruiting
Caloric Restriction
0 Actively Recruiting
Obesity
0 Actively Recruiting
Diet
6 Actively Recruiting
Not Applicable
Rybelsus Reviews: What are patients saying about Rybelsus?
5Patient Review
7/4/2022 I've been taking 7mg for almost a year now and have seen some great results like losing 20lbs, lower blood sugar, and A1c. I also haven't experienced any negative side effects, which is amazing.
5Patient Review
7/4/2022 I've been taking 7mg of this medication for nearly a year and have seen some great results, like losing 20lbs and bringing my blood sugar down. My A1C is also down with no negative side effects!
5Patient Review
8/29/2022 I gradually increased my dosage over the course of three months and saw significant results. I lost 17 pounds without any negative side effects.
4.7Patient Review
11/2/2022 At first, this medication made me feel nauseous and I had no appetite. However, once I got used to it, it was much better. I also discovered that if you hold the pill in your mouth for too long, it has a really bitter taste (yuck). So my advice is to put the pill near the back of your tongue and quickly drink some water. In just three months, my A1C went from 8.2 to 6.4, and I lost six pounds in addition to taking 1000 mg Metformin.
4.3Patient Review
9/13/2021 I've had a lot of trouble in the past taking diabetic medication, but Rybellsus has been different. No upset stomach or urinary problems. Blood sugar is better controlled and I'm hoping to be moved up to 14mg soon.
4.3Patient Review
7/18/2022 I saw a significant drop in my blood sugar levels after taking this medication.
3.7Patient Review
4/4/2022 I've been taking rybelsus for three weeks now and have had no major issues. I will be upping my dosage to seven milligrams next week, and so far everything has been going well. The only thing I experienced at the beginning was slight lightheadedness, but that passed quickly.
3Patient Review
5/11/2022 I was using 3mg for a month and experiencing symptoms like bladderfulness and nausea. I increased the dosage to 7mg for the last 15 days, but the side effects are the same. The only difference is that my sugar levels have come down.
2.7Patient Review
10/23/2021 I had some normal side effects at first, but they got worse after a few days instead of better. I stopped taking the pill after 15 days because I couldn't handle the side effects anymore.
2.7Patient Review
4/18/2022 The smaller strength pills had no real effect on appetite. The largest dose caused extreme nausea and diarrhea. Could not eat to take nailing because I felt so sick. The should be other strengths
1.7Patient Review
7/12/2022 I started taking Rybelsus last year and again this year. No effect on weight loss, no effect on my blood sugar. I had stomach pain, heartbeat, constipation and lower back pain. After every 6 month I had problem with vomiting. I think Rybelsus give me Acute gallbladder disease. Every time I stop taking it, after a few days all the side effect was gone.I will never take it again. The biggest effect of Rybelsus was on my wallet
1.7Patient Review
9/1/2022 I have been taking Rybelsus for a year and a half at the 7 mg dosage. Unfortunately, it has made my life quite miserable. I experience terrible bloating, stomach pain, and gas on a regular basis. I've even lost around 40 pounds because of how little I can eat while on this medication. Additionally, it started giving me heart palpitations and is no longer effectively controlling my blood sugar levels - even when I consume very few carbs. So, I'm planning to speak with my doctor soon about finding an alternative treatment option.
1.7Patient Review
6/7/2022 This medication made me so sick after only the second dose. I had diarrhea, vomiting and nausea so bad that I couldn't move. I discontinued it right away. Of course you will lose weight if you can't keep food down.
1.7Patient Review
6/22/2022 My A1C readings did not budge after using this treatment, and if anything, my average daily glucose readings went up by over 150 points.
1.3Patient Review
9/24/2022 I'm on day four of the treatment, and I've been feeling a strong metallic taste in my mouth. Additionally, it feels like I was punched in my right kidney. If these symptoms don't improve by day seven, I'll be stopping the medication.
Patient Q&A Section about rybelsus
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does the drug Rybelsus do?
"Rybelsus is a hormone that helps to lower blood sugar levels by mimicking the effects of the protein GLP-1, which is found naturally in the body and helps to control blood sugar levels."
Answered by AI
Is Rybelsus the same as metformin?
"A major difference between Rybelsus and metformin is that Rybelsus is a newer brand-name medication that isn't available as a generic yet, while metformin is available as a lower-cost generic."
Answered by AI
Is Rybelsus a weight loss pill?
"If you are an adult with type 2 diabetes, RYBELSUS® may be a medication option for you. This medication is intended to be used in conjunction with diet and exercise to improve blood sugar levels and A1C. Although weight loss is not a primary goal of this medication, some patients may experience weight loss as a side effect."
Answered by AI
How effective is Rybelsus for weight loss?
"Although Rybelsus is not explicitly marketed as a weight loss drug, many people report losing weight while taking it. On average, people lost 5 pounds (2.3 kg) while taking the 7 mg dose, and 8.1 pounds (3.7 kg) while taking the 14 mg dose. One of the ways Rybelsus is believed to work is by helping to make users feel full after a meal."
Answered by AI