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What is Dilt-Cd
DiltiazemThe Generic name of this drug
Treatment SummaryDiltiazem is a medication used to treat high blood pressure, abnormal heart rhythms, and chest pain. It works by blocking the influx of calcium into the cells of the heart and blood vessels, causing them to relax and widen. Diltiazem is available in both oral and intravenous forms and is commonly sold under the brand names Cardizem and Tiazac. It has also been used off-label to treat anal fissures, migraine prevention, pulmonary hypertension, and night-time leg cramps.
Cardizemis the brand name
Dilt-Cd Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cardizem
Diltiazem
1982
656
Approved as Treatment by the FDA
Diltiazem, commonly known as Cardizem, is approved by the FDA for 4 uses which include Coronary Vasospasm and Hypertensive disease .Coronary Vasospasm
Helps manage Coronary Artery Vasospasm
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Angina, Stable
Helps manage Chronic Stable Angina Pectoris
Angina Pectoris
Helps manage Anginal Pain
Effectiveness
How Dilt-Cd Affects PatientsDiltiazem is a drug used to treat high blood pressure. It works by relaxing the walls of the blood vessels, which lowers the pressure in the vessels, reducing the risk of strokes and heart attacks. It also reduces heart rate. The amount of blood pressure reduction depends on how high the blood pressure is. Studies on people with essential hypertension have shown that taking diltiazem can reduce diastolic blood pressure by a range of 1.9-8.6 mmHg, depending on the dose taken. People with chronic stable angina have been found to have increased exercise tolerance when taking diltiazem. In a
How Dilt-Cd works in the bodyDiltiazem works by blocking calcium channels in the heart and blood vessels, which reduces the amount of calcium entering the cells. This lowers the amount of calcium in the cells, allowing them to relax and reducing tension in the muscle. This leads to dilation of the coronary and systemic arteries, increased oxygen delivery to the heart muscle, decreased total peripheral resistance, decreased blood pressure, and decreased afterload. Diltiazem also decreases heart rate and contractility, making it an effective treatment for chronic stable angina.
When to interrupt dosage
The advocated amount of Dilt-Cd is contingent upon the diagnosed state, including prophylaxis of migraine headaches, Fissure;Anal and Anginal Pain. The dosage is subject to the administration route specified in the table below.Condition
Dosage
Administration
Fissure;Anal
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Atrial Fibrillation
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Paroxysmal Supraventricular Tachycardia (PSVT)
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Cardiomyopathy, Dilated
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina Pectoris
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Migraine Disorders
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
leg cramps
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Proteinuria
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina Pectoris, Variant
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Pulmonary Hypertension
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Diabetic Neuropathy
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Coronary Vasospasm
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Angina, Stable
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Hypertensive disease
, 120.0 mg, 180.0 mg, 240.0 mg, 300.0 mg, 360.0 mg, 420.0 mg, 100.0 mg, 60.0 mg, 90.0 mg, 30.0 mg, 5.0 mg/mL, 1.0 mg/mL, 0.83 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution - Intravenous, Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Injection, Injection - Intravenous, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intravenous, Tablet, coated, Tablet, coated - Oral, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Warnings
Dilt-Cd ContraindicationsCondition
Risk Level
Notes
Heart Attack
Do Not Combine
accessory bypass tract
Do Not Combine
accessory bypass tract
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
Ventricular Tachycardia
Do Not Combine
absence of a functioning ventricular pacemaker
Do Not Combine
third degree AV block
Do Not Combine
Pulmonary Congestion
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Hypotension
Do Not Combine
Common Dilt-Cd Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Diltiazem.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Diltiazem.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Diltiazem.
Alfentanil
Major
The metabolism of Alfentanil can be decreased when combined with Diltiazem.
Amifostine
Major
Diltiazem may increase the hypotensive activities of Amifostine.
Dilt-Cd Toxicity & Overdose RiskDiltiazem has an oral LD50 ranging from 415 to 740mg/kg in mice and 560 to 810 mg/kg in rats. In dogs, the oral LD50 is estimated to be over 50 mg/kg, and in monkeys it is 360 mg/kg. Reports of overdoses from doses as low as 1g up to 18g have been reported and can cause symptoms such as slow heartbeat, low blood pressure, heart block, or heart failure. Treating an overdose with diltiazem can involve supportive measures, gastric lavage, activated charcoal, and intravenous calcium. Long-term use in animals
Dilt-Cd Novel Uses: Which Conditions Have a Clinical Trial Featuring Dilt-Cd?
228 active trials are currently in progress to assess the potential of Dilt-Cd in alleviating Atrial Fibrillation, Coronary Artery Spasm and Paroxysmal Supraventricular Tachycardia (PSVT).Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
106 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Angina, Stable
1 Actively Recruiting
Not Applicable
Angina Pectoris, Variant
0 Actively Recruiting
Paroxysmal Supraventricular Tachycardia (PSVT)
2 Actively Recruiting
Phase 3, Phase 2
Diabetic Neuropathy
7 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Cardiomyopathy, Dilated
0 Actively Recruiting
Proteinuria
4 Actively Recruiting
Phase 2, Phase 3
leg cramps
0 Actively Recruiting
Pulmonary Hypertension
23 Actively Recruiting
Phase 4, Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1
Angina Pectoris
2 Actively Recruiting
Not Applicable, Phase 4
Hypertensive disease
21 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Vasospasm
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Fissure;Anal
0 Actively Recruiting
Dilt-Cd Reviews: What are patients saying about Dilt-Cd?
4.7Patient Review
6/20/20084.3Patient Review
6/15/2009 I felt really dizzy after taking this medication, and it also made me quite depressed. I was in a fog all day long. I think that the dose is way too high for someone who's trying this drug for the first time - 120 mg.
4Patient Review
5/28/2009 I took this drug for about six weeks and, at first, experienced some adjustments like feeling off-balance. Then I started swelling around my eyes and feeling tightness in my face and chest. Overall, it was an awful experience that led me to the ER where they thought I was having a heart attack. Needless to say, I'll never take another calcium channel blocker!
4Patient Review
7/31/2009 My blood pressure was well-controlled on cartia xt, but since switching to dilt cd it has risen back up again. This isn't an effective medication for me.
4Patient Review
11/29/2009 I originally was prescribed 280MG of this medication, but had to reduce my dosage to 180MG because I wheezed so loudly at night that it would wake me up. It was prescribed after I had a pacemaker installed.
3.7Patient Review
9/22/2009 Unfortunately, this medication gave me GERD.
3Patient Review
3/15/2010 This treatment is effective. I'm grateful for modern medicine.
2.3Patient Review
6/5/2009 DILT-CD is the only medication I've taken for high blood pressure that doesn't have any significant side effects. Some downsides are that it can cause pain in my breast and make me urinate more frequently, but overall it's a decent medication.
2Patient Review
5/15/2009 I've been taking this medication for two decades to keep chest pains at bay and mitigate Reynauld' Syndrome. I take it before bed so that the side effects (which include night sweats) don't bother me while I'm trying to sleep.
2Patient Review
7/7/2009 I haven't experienced any adverse effects, which is great. The medication has been successful in controlling my atrial fib. I take 120 mg per dose.
1.3Patient Review
11/8/2007Patient Q&A Section about dilt-cd
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is diltiazem CD used for?
"Diltiazem is used to treat high blood pressure and chest pain by relaxing blood vessels and increasing blood and oxygen supply to the heart."
Answered by AI
Is diltiazem ER the same as diltiazem CD?
"Diltiazem is a medication used to treat high blood pressure and prevent chest pain. It works by relaxing blood vessels, which decreases the amount of work your heart has to do. Diltiazem belongs to a group of medications called calcium channel blockers."
Answered by AI
Is diltiazem CD long acting?
"Diltiazem Long-Acting Capsules are used to treat high blood pressure and a type of long-term chest pain known as stable angina."
Answered by AI
What are the side effects of diltiazem CD 120 mg?
"Lightheadedness, dizziness, weakness, nausea, flushing, headache, and constipation may occur. If any of these effects persist or get worse, tell your doctor or pharmacist right away. To lower the risk of dizziness and lightheadedness, get up slowly when going from a sitting or lying down position."
Answered by AI