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Almond Oil vs Hydroquinone for Hyperpigmentation

Phase 4
Waitlist Available
Led By Raja Sivamani, MD MS AP
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 16 weeks
Awards & highlights
Drug Has Already Been Approved
Pivotal Trial
No Placebo-Only Group

Summary

This trial will compare how well almond oil and hydroquinone lighten skin and change the skin's microbiome.

Who is the study for?
This trial is for premenopausal women with medium to dark skin (Fitzpatrick types 3-6) who haven't smoked in the past year. They shouldn't have nut allergies, autoimmune photosensitive conditions, or collagen production disorders. Participants must not have had facial cosmetic procedures in the last 4 months and agree to stop using certain skincare products.
What is being tested?
The study compares almond oil's effects on facial pigmentation and skin microbiome changes against hydroquinone, a known pigment-reducing agent. Women will use either almond oil or hydroquinone topically on their face to see which one works better for hyperpigmentation.
What are the potential side effects?
Potential side effects of topical treatments may include mild irritation, redness, itching at the application site for both almond oil and hydroquinone. Hydroquinone might also cause unwanted skin lightening or allergic reactions.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~16 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 16 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Appearance of facial redness
Intensity of facial pigment
Quantification for the presence of species within the genus Cutibacteria, Staphyloccoccus, and Ralstonia
+2 more

Awards & Highlights

Drug Has Already Been Approved
The FDA has already approved this drug, and is just seeking more data.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Almond oilExperimental Treatment1 Intervention
Almond Oil Pressed Cold
Group II: HydroquinoneActive Control1 Intervention
Hydroquinone 2% cream

Find a Location

Who is running the clinical trial?

University of California, DavisLead Sponsor
946 Previous Clinical Trials
4,756,080 Total Patients Enrolled
Raja Sivamani, MD MS APPrincipal InvestigatorUC Davis Dermatology
4 Previous Clinical Trials
148 Total Patients Enrolled
1 Trials studying Hyperpigmentation
22 Patients Enrolled for Hyperpigmentation
~2 spots leftby Mar 2025
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