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What is Esomeprazole Sodium
EsomeprazoleThe Generic name of this drug
Treatment SummaryEsomeprazole (Nexium) is a medication used to reduce stomach acid production in people with gastrointestinal disorders. It is used to treat gastroesophageal reflux disease (GERD), peptic ulcer disease, and conditions caused by excessive stomach acid production. Esomeprazole works by blocking the action of an enzyme that helps produce stomach acid. While it is generally well-tolerated, long-term use of this medication may increase the risk of some health issues, such as bacterial infections, reduced absorption of micronutrients, and an increased risk of cardiovascular events. To avoid a rebound effect
Nexiumis the brand name
Esomeprazole Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nexium
Esomeprazole
2001
347
Approved as Treatment by the FDA
Esomeprazole, otherwise called Nexium, is approved by the FDA for 3 uses including Heartburn and Helicobacter Pylori Infection .Heartburn
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin
Heartburn
Helps manage Gastro-esophageal Reflux Disease (GERD)
Effectiveness
How Esomeprazole Sodium Affects PatientsEsomeprazole helps treat gastroesophageal reflux disease (GERD), heal erosive esophagitis, and prevent duodenal ulcer recurrence. It works by blocking the acid secretion in your stomach, so that less acid enters the stomach's lining. Esomeprazole is similar to other drugs in its class (PPIs) in that it can reduce the activity of an enzyme important for cardiovascular health, which may increase the risk of cardiovascular events. Despite potential long-term side effects, esomeprazole is widely used in North America due to its good safety profile and availability
How Esomeprazole Sodium works in the bodyEsomeprazole works by blocking the final step in the production of stomach acid. It does this by attaching to certain proteins on the surface of the stomach cells that produce acid. This prevents the stomach from making acid no matter what the trigger is. This binding is permanent, so it lasts longer than a day and new proteins need to be formed to start producing acid again.
When to interrupt dosage
The proposed dosage of Esomeprazole Sodium is contingent upon the diagnosed ailment, including Curling Ulcer, Hemorrhage and Critical Illness. The degree of dose fluctuates as per the technique of administration (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) specified in the table underneath.Condition
Dosage
Administration
Hemorrhage
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Heartburn
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
antibacterial therapy
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Hemorrhage
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Stress Ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Zollinger-Ellison Syndrome
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Curling Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Peptic Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
maintenance of healing Erosive esophagitis
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Gastric ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Peptic Ulcer
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Erosive Esophagitis
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Critical Illness
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Helicobacter Pylori Infection
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
prophylaxis of Stress Ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Heartburn
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
develop NSAID-induced gastric ulcers
20.0 mg, , 40.0 mg, 20.0 mg/mL, 40.0 mg/mL, 10.0 mg, 2.5 mg, 5.0 mg, 24.65 mg, 49.3 mg
, Capsule, delayed release, Oral, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Granule, delayed release, Granule, delayed release - Oral, Injection, Injection - Intravenous, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Tablet, Tablet - Oral, Kit, Capsule, Capsule - Oral, Granule, for suspension, extended release, For suspension - Oral, For suspension, Granule, for suspension, extended release - Oral, Capsule, coated pellets, Kit - Oral, Capsule, coated pellets - Oral, Tablet, film coated - Oral, Tablet, film coated
Warnings
Esomeprazole Sodium has one contraindication and should not be administered with any of the conditions detailed in the subsequent table.Esomeprazole Sodium ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Esomeprazole Sodium Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.
Atazanavir
Major
Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Esomeprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.
Esomeprazole Sodium Toxicity & Overdose RiskSide effects of taking too much of this drug may include blurry vision, confusion, fatigue, dry mouth, facial warmth, headache, nausea, racing heartbeat, and excessive sweating.
Esomeprazole Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Esomeprazole Sodium?
There are currently 26 active clinical trials assessing the potential of Esomeprazole Sodium to improve outcomes in patients with previous gastric or duodenal ulcer, Stomach Ulcer and Peptic Ulcer.Condition
Clinical Trials
Trial Phases
Hemorrhage
1 Actively Recruiting
Phase 4
Curling Ulcer
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3
Gastric ulcer
0 Actively Recruiting
Helicobacter Pylori Infection
1 Actively Recruiting
Not Applicable
develop NSAID-induced gastric ulcers
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
Stress Ulcers
0 Actively Recruiting
maintenance of healing Erosive esophagitis
0 Actively Recruiting
Peptic Ulcer
0 Actively Recruiting
Critical Illness
0 Actively Recruiting
Hemorrhage
0 Actively Recruiting
Heartburn
11 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
Peptic Ulcer
0 Actively Recruiting
prophylaxis of Stress Ulcers
0 Actively Recruiting
Patient Q&A Section about esomeprazole sodium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is esomeprazole sodium used for?
"Esomeprazole injection is used to treat conditions where there is too much acid in the stomach. It is used for the short-term treatment (up to 10 days) of gastroesophageal reflux disease (GERD) with erosive esophagitis in adults and children 1 month of age and older."
Answered by AI
Is it OK to take esomeprazole every day?
"You may only take esomeprazole for a few weeks or months if it has been prescribed for you, depending on your condition. Sometimes your doctor may advise you to take it for longer, even many years. Your doctor may only suggest taking esomeprazole when you have symptoms, which means you will not have to take it every day."
Answered by AI
Is esomeprazole magnesium the same as Nexium?
"That means you may need to take it with other drugs.
Esomeprazole magnesium is sold as both the brand-name drug Nexium and a generic drug. Generic drugs typically cost less money than their brand-name counterparts. In some instances, generic drugs may not be offered in the same strength or form as the brand-name drug. Esomeprazole magnesium may be used in tandem with other drugs as part of a combination therapy."
Answered by AI
What is esomeprazole 40 mg used for?
"Nonprescription esomeprazole is used to treat frequent heartburn in adults. Esomeprazole is a type of medication called a proton pump inhibitor, which decreases the amount of acid made in the stomach."
Answered by AI