Edecrin

induction of Diuresis, Nephrotic Syndrome, Ascites + 5 more

Treatment

11 FDA approvals

20 Active Studies for Edecrin

Treatment for

induction of Diuresis

What is Edecrin

Etacrynic acidThe Generic name of this drug

Treatment SummaryThis drug is a diuretic that helps rid the body of excess salt and water. It works by blocking the absorption of sodium, potassium, and chloride in the kidneys, which causes more of these ions to be excreted in the urine and results in increased urinary output. This drug is known as a “loop diuretic” or “high ceiling diuretic” and is often prescribed to treat conditions such as edema and high blood pressure.

Ethacrynic Acidis the brand name

Edecrin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ethacrynic Acid

Etacrynic acid

1967

Approved as Treatment by the FDA

Etacrynic acid, otherwise called Ethacrynic Acid, is approved by the FDA for 11 uses including Congestive Heart Failure (CHF) and Edema .

Congestive Heart Failure (CHF)

Edema

Cirrhosis of the Liver

Congenital Heart Disease (CHD)

Helps manage Congenital Heart Disease (CHD)

Ascites

Helps manage Ascites

Nephrotic Syndrome

Cirrhosis

Congenital Heart Defect

Helps manage Congenital Heart Disease (CHD)

Ascites

Helps manage Ascites

Swollen feet or ankles

Congestive Heart Failure

Effectiveness

How Edecrin Affects PatientsEthacrynic acid is a type of diuretic, which means it helps the body get rid of extra fluid. It does this by blocking sodium from being reabsorbed by the kidneys, so it can be passed out of the body. This drug is very effective in people with kidney problems, as it can help them get rid of excess fluid. Unlike other diuretics, ethacrynic acid doesn't affect how well the kidneys filter or how much blood flows to them, except when the patient has lost a lot of fluid quickly.

How Edecrin works in the bodyEthacrynic acid works as a diuretic to reduce blood pressure. It achieves this by preventing sodium, potassium, and chloride from being absorbed into the body, and instead causes them to be flushed out with urine. This leads to a decrease in plasma and extracellular fluid, which lowers both blood pressure and cardiac output. It works in a different way than carbonic anhydrase inhibitors.

When to interrupt dosage

The proposed dosage of Edecrin is reliant upon the diagnosed condition, such as Swelling, Cirrhosis and Ascites. The measure of dosage shifts with the technique of delivery (e.g. Tablet or Powder, for solution - Intravenous) featured in the table beneath.

Condition

Dosage

Administration

induction of Diuresis

25.0 mg, , 5.0 mg/mL, 50.0 mg

, Oral, Tablet, Tablet - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous

Nephrotic Syndrome

25.0 mg, , 5.0 mg/mL, 50.0 mg

Ascites

25.0 mg, , 5.0 mg/mL, 50.0 mg

Swollen feet or ankles

25.0 mg, , 5.0 mg/mL, 50.0 mg

Cirrhosis

25.0 mg, , 5.0 mg/mL, 50.0 mg

Congenital Heart Defect

25.0 mg, , 5.0 mg/mL, 50.0 mg

Diuresis

25.0 mg, , 5.0 mg/mL, 50.0 mg

Congestive Heart Failure

25.0 mg, , 5.0 mg/mL, 50.0 mg

Warnings

There are 20 known major drug interactions with Edecrin.

Common Edecrin Drug Interactions

Drug Name

Risk Level

Description

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Neomycin.

Tenofovir

Major

Etacrynic acid may increase the nephrotoxic activities of Tenofovir.

Tenofovir alafenamide

Major

Etacrynic acid may increase the nephrotoxic activities of Tenofovir alafenamide.

Tenofovir disoproxil

Major

Etacrynic acid may increase the nephrotoxic activities of Tenofovir disoproxil.

Acebutolol

Minor

The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Acebutolol.

Edecrin Toxicity & Overdose RiskTaking too much of this drug can cause excessive urination, leading to loss of important minerals and salts from the body.

image of a doctor in a lab doing drug, clinical research

Edecrin Novel Uses: Which Conditions Have a Clinical Trial Featuring Edecrin?

166 active clinical trials are currently underway to assess the potential of Edecrin in treating Nephrotic Syndrome, Ascites and Cirrhosis.

Condition

Clinical Trials

Trial Phases

Cirrhosis

51 Actively Recruiting

Phase 1, Not Applicable, Phase 3, Phase 4, Phase 2, Early Phase 1

Nephrotic Syndrome

4 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Diuresis

0 Actively Recruiting

induction of Diuresis

0 Actively Recruiting

Ascites

3 Actively Recruiting

Not Applicable, Phase 2

Congenital Heart Defect

33 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1

Congestive Heart Failure

12 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Swollen feet or ankles

6 Actively Recruiting

Phase 2, Not Applicable

Edecrin Reviews: What are patients saying about Edecrin?

5Patient Review

1/21/2009

Edecrin for Visible Water Retention

Quickly and effectively removed the fluid retention in my right leg caused by amlodipine.

4.3Patient Review

11/21/2013

Edecrin for High Blood Pressure

I have an allergy to sulfa drugs, so this is the only water pill I can take. It works well for me. When I run out and have to wait to get more, my blood pressure goes up significantly.

4Patient Review

6/25/2012

Edecrin for High Blood Pressure

I've been on this medication for two months and it's been working well so far. I'm allergic to sulfa, and was previously taking bystolic; however, I had to stop because it made me sick. Make sure to check for sulfites in everything if you're also allergic.

4Patient Review

8/3/2012

Edecrin for Visible Water Retention

I would appreciate learning more about the manufacturer of this drug, Draxis.

3.7Patient Review

3/12/2008

Edecrin for Visible Water Retention

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about edecrin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of diuretic is Edecrin?

"Ethacrynic acid works as a loop diuretic in the kidney to remove certain electrolytes and extra fluid from your body in order to lower swelling."

Answered by AI

What is Edecrin used for?

"This medication is used to decrease swelling that is caused by conditions such as cancer, congestive heart failure, liver disease, and kidney disease. This effect can help improve kidney function and lessen symptoms such as trouble breathing and swelling in the ankles, feet, hands, or stomach."

Answered by AI

Is Edecrin ototoxic?

"Some patients experience permanent hearing loss as a result of taking EDECRIN, especially those also taking other ototoxic drugs. Ototoxic drugs are known to increase the potential for hearing loss (see Drug Interactions in the precautions section)."

Answered by AI

Is Edecrin a loop diuretic?

"Edecrin is a loop diuretic used to treat fluid retention in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome."

Answered by AI