Gyne-Lotrimin

Erythrasma, Tinea Pedis, Inflammation + 37 more

Treatment

20 Active Studies for Gyne-Lotrimin

What is Gyne-Lotrimin

Clotrimazole

The Generic name of this drug

Treatment Summary

Clotrimazole is an antifungal medication used to treat fungal infections. It belongs to the imidazole class of antifungals and has a broad range of antifungal activity. It comes in several forms, including creams, pessaries, and troche formulations. It has been studied for its potential to treat sickle cell disease, malaria, and some cancers. Clotrimazole is well-tolerated and has few side effects, making it a popular treatment for yeast infections and athlete's foot.

Mycelex

is the brand name

image of different drug pills on a surface

Gyne-Lotrimin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Mycelex

Clotrimazole

1983

116

Effectiveness

How Gyne-Lotrimin Affects Patients

Clotrimazole is a drug used to fight fungal infections. It works by changing the cell membranes of pathogenic yeasts. At low concentrations, it stops the growth of the fungi, and at higher concentrations, it can kill them. In the past, resistance to clotrimazole was rare, however it is now more common. Clotrimazole is usually a fungistatic drug but has fungicidal properties at higher concentrations.

How Gyne-Lotrimin works in the body

Clotrimazole works by disrupting the cell membrane of fungi, which stops them from growing. It does this by blocking the production of ergosterol, a hormone-like molecule which helps the cell build and maintain its membrane. Clotrimazole also has other effects on fungi, such as blocking calcium-dependent potassium channels and voltage-dependent calcium channels, and depleting intracellular calcium. These effects are separate from its anti-fungal properties.

When to interrupt dosage

The measure of Gyne-Lotrimin is contingent upon the recognized affliction, including Vulvitis, Trichophytosis and Radiotherapy Side Effects. The dosage varies as per the technique of implementation (e.g. Cream or Topical) presented in the table beneath.

Condition

Dosage

Administration

Inflammation

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Trichomonas Vaginitis

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Vulvitis

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Vaginitis

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Balanitis candida

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Skin candida

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Genital candidiasis

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Ringworm

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Tinea

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Cellulitis

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

symptomatic Tinea Corporis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Tinea cruris

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Oropharyngeal Candidiasis

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Tinea

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Epidermophyton floccosum

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Candidiasis, Vulvovaginal

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Communicable Diseases

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Mixed Vaginal Infections

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Tinea Cruris

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Chemotherapy Effects

0.01 mg/mg, , 10.0 mg/mL, 0.02 mg/mg, 1.0 mg/mL, 10.0 mg, 0.05 mg/mg, 0.035 mg/mg, 0.042 mg/mg, 0.01 mL/mL, 4.0 mg/mL, 6.0 mg/mL, 0.00001 mg/mg, 1.0 %, 500.0 mg, 2.0 %, 10.0 %, 100.0 mg, 200.0 mg, 1.0 mg/mg, 1000.0 mg/mL, 10.0 mg/mg, 0.0001 mg/mg, 0.011 mg/mg, 0.000001 mg/mg, 0.01 mg/mL, 0.006 mg/mL, 100.0 mg/mg

, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Vaginal, Cream - Vaginal, Liquid, Liquid - Topical, Oral, Lozenge, Lozenge - Oral, Aerosol, foam, Aerosol, foam - Topical, Ointment, Ointment - Topical, Kit, Aerosol, spray - Topical, Aerosol, spray, Oil, Oil - Topical, Powder, Powder - Topical, Spray, Spray - Topical, Gel, Gel - Topical, Solution, Solution - Topical, Tablet - Vaginal, Tablet, Oral; Topical; Vaginal, Capsule; Cream, Capsule; Cream - Oral; Topical; Vaginal, Cream - Topical; Vaginal, Topical; Vaginal, Suppository - Vaginal, Suppository, Cream; Suppository, Cream; Suppository - Topical; Vaginal, Oral; Topical, Lozenge - Oral; Topical, Capsule; Cream; Kit, Capsule; Cream; Kit - Oral; Topical, Troche, Troche - Oral, Capsule; Cream - Oral; Topical, Cream; Kit, Cream; Kit; Tablet, Cream; Kit; Tablet - Topical; Vaginal, Cream; Kit - Topical; Vaginal, Spray - Extracorporeal, Extracorporeal, Kit - Topical

Warnings

Gyne-Lotrimin Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Clotrimazole may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Clotrimazole may interact with Pulse Frequency

There are 20 known major drug interactions with Gyne-Lotrimin.

Common Gyne-Lotrimin Drug Interactions

Drug Name

Risk Level

Description

Capmatinib

Major

The serum concentration of Capmatinib can be decreased when it is combined with Clotrimazole.

Rimegepant

Major

The metabolism of Rimegepant can be increased when combined with Clotrimazole.

(R)-warfarin

Moderate

The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Clotrimazole.

(S)-Warfarin

Moderate

The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Clotrimazole.

4-hydroxycoumarin

Moderate

The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Clotrimazole.

Gyne-Lotrimin Toxicity & Overdose Risk

Clotrimazole is unlikely to cause poisoning when used topically or accidentally ingested. There is no specific antidote for overdose. Animal studies have not revealed any effects on fertility, though limited data exists on its use in pregnant women. Clotrimazole and its metabolites are excreted in breast milk so it should not be used while breastfeeding.

Gyne-Lotrimin Novel Uses: Which Conditions Have a Clinical Trial Featuring Gyne-Lotrimin?

293 active studies are currently examining the potential of Gyne-Lotrimin in providing relief for Atopic Dermatitis, Tinea inguinalis and Balanitis candida.

Condition

Clinical Trials

Trial Phases

Tinea Versicolor

0 Actively Recruiting

Balanitis candida

0 Actively Recruiting

Mixed Vaginal Infections

0 Actively Recruiting

Skin Diseases

0 Actively Recruiting

symptomatic Tinea Corporis caused by Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum

0 Actively Recruiting

Tinea cruris

0 Actively Recruiting

cutaneous candidiasis

0 Actively Recruiting

Yeast Infection

0 Actively Recruiting

Oropharyngeal Candidiasis

0 Actively Recruiting

Tinea cruris

0 Actively Recruiting

Candidiasis, Vulvovaginal

0 Actively Recruiting

Skin candida

0 Actively Recruiting

Epidermophyton floccosum

0 Actively Recruiting

Malassezia

0 Actively Recruiting

Inflammation

58 Actively Recruiting

Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4

Cellulitis

0 Actively Recruiting

Steroids

0 Actively Recruiting

Radiotherapy Side Effects

2 Actively Recruiting

Phase 2, Not Applicable

Candidiasis, Vulvovaginal

0 Actively Recruiting

Tinea Pedis

0 Actively Recruiting

Gyne-Lotrimin Reviews: What are patients saying about Gyne-Lotrimin?

4.7

Patient Review

1/16/2013

Gyne-Lotrimin for Yeast Infection of Vagina and Vulva

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about gyne-lotrimin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lotrimin the same as Monistat?

"Gyne-Lotrimin and Monistat contain chemical compounds that set them apart from other over-the-counter treatments for yeast infections that contain natural ingredients. These homeopathic products have been available for a while, but women with severe symptoms often needed a prescription product."

Answered by AI

Is Gyne-Lotrimin over-the-counter?

"Gyne-Lotrimin is a vaginal cream that is used to treat yeast infections. It is available over-the-counter and in generic versions."

Answered by AI

Do I need a prescription for Gyne-Lotrimin?

"Gyne-Lotrimin is a prescription medication that is used to treat the symptoms of fungal infections. These infections include athlete's foot, jock itch, ringworm, and yeast infections. Gyne-Lotrimin may be used by itself or with other medications."

Answered by AI

Can Lotrimin be used for female yeast infection?

"It works by preventing the growth of yeast (fungus) that causes the infection.

This medication is used to treat vaginal yeast infections. Clotrimazole reduces vaginal burning,itching, and discharge occur with this condition. This medication is an azole antifungal. Yeast (fungus) that causes the infection."

Answered by AI

Clinical Trials for Gyne-Lotrimin

Image of ALS Global in Irving, United States.

GX-03 for Eczema

18 - 70
All Sexes
Irving, TX

This is a randomized, double-blind, vehicle-controlled clinical study designed to evaluate the efficacy and safety of GX-03, a topically applied emollient, in adult subjects with moderate to severe eczema. Approximately 120 adult participants will be enrolled and randomized in a 1:1 ratio to receive either GX-03 or a petrolatum-based vehicle control for 8 consecutive weeks. Efficacy will be assessed using validated clinical outcome measures, including the Eczema Area and Severity Index (EASI), the Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD™), and the Peak Pruritus Numeric Rating Scale (PP-NRS). Safety will be evaluated through monitoring of treatment-emergent adverse events throughout the study period.

Phase 2
Recruiting

ALS Global

Turn Therapeutics

Image of Montana State University in Bozeman, United States.

Haskap Berries for Exercise Performance Recovery

18 - 35
All Sexes
Bozeman, MT

The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following: * Do Haskaps speed the recovery of oxidative stress and inflammation markers after an intense lower body workout in resistance trained adults? * Do Haskaps speed the recovery of performance measures after an intense lower body workout in resistance trained adults? * The data collected in this investigation may also be used to ask additional questions not yet identified. For example, the investigators may use the stored samples to evaluate how the blood metabolites of participants differ before and after intense exercise. These additional questions are called secondary analyses. Please note that no genetic analysis will be conducted and racial and ethnic differences among participants will not be used in any secondary analyses. Researches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance. * Participants will be asked to drink either Haskap juice or placebo and follow a low polyphenolic diet * Participants will perform an intense resistance workout * Participants will have their blood drawn before and after the workout * Performance will be analyzed at 24, 48 and 72 hours after the workout

Recruiting
Paid Trial

Montana State University

Mary P Miles

Image of Seeding Labs INC in Austin, United States.

Tailored Recommendations for Infant Gut Microbiome

No minimum age - 3
All Sexes
Austin, TX

The goal of this clinical trial is to learn whether microbiome analysis, education, and personalized recommendations can improve gut health and reduce early markers of immune-related conditions in infants aged 0-3 months delivered via Cesarean section. The study aims to determine whether these interventions can increase beneficial bacteria, decrease C-section-associated microbiome signatures, reduce opportunistic pathogens, and improve functional potential for HMO digestion and SCFA production. The study also seeks to assess whether improvements in microbiome composition are associated with a reduced prevalence of early atopic symptoms. Researchers will compare three groups: a full intervention arm that receives microbiome reports, coaching, personalized recommendations, and educational materials; a limited intervention arm that receives simplified reports and basic recommendations; and a control arm that receives no results until study completion. This design allows evaluation of both a comprehensive intervention and a more scalable, minimal-results model. Participants will: 1. Provide six microbiome stool samples over a 24-month period. 2. Provide additional small stool samples at two timepoints for exploratory metabolomic analysis. 3. Receive microbiome reports and guidance according to their assigned study arm. 4. Complete surveys on infant health history, symptoms, diet, and environmental exposures. 5. Participate in standardized eczema assessment(s) administered by a Nurse Practitioner and evaluated by a Pediatric Allergy Specialist if any symptoms are reported. This study seeks to demonstrate that targeted microbiome support can positively shift gut microbial development in C-section infants and may reduce risks linked to the early stages of the atopic march. Findings may inform scalable strategies for delivering microbiome-based support in early life and improve long-term health outcomes for this high-risk population.

Waitlist Available
Has No Placebo

Seeding Labs INC

Qian Yuan, MD

Seeding, Inc DBA Tiny Health

Image of University of New Brunswick in Fredericton, Canada.

Mediterranean Diet for Toddler Health

24 - 36
All Sexes
Fredericton, Canada

Toddlerhood (ages 2-3) is a critical window when the gut microbiome is still developing and eating habits are being established. Yet, many Canadian toddlers eat diets high in sugar and salt, which may affect long-term health. This study will test whether a MED diet can improve dietary inflammation, gut health, and body composition in toddlers and whether a tailored nutrition education program for parents can help families maintain healthy eating patterns. In this study, toddlers will be randomly assigned to a 3-week MED diet or their usual diet. Families in the MED diet group will receive free meal boxes for the 3 weeks, plus guidance from a nutrition researcher through a structured education program. The standard diet group will continue their regular diet with general nutrition advice. Researchers will collect dietary information, body composition assessments, and stool samples to measure gut microbiome composition and metabolites. This first study of a controlled diet intervention in toddlers, combining behavioral support, high-quality food provision, and advanced gut microbiome analysis, will help understand how early diet shapes lifelong eating habits and health, guiding public health strategies and precision nutrition approaches to prevent chronic disease from early life.

Waitlist Available
Has No Placebo

University of New Brunswick

Dr. Maryam Kebbe, PhD, CLC

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Image of UConn Health in Farmington, United States.

Cognitive Remediation for Memory and Thinking Difficulties

18+
All Sexes
Farmington, CT

The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aims to answer are: * Does computerized cognitive remediation improve cognitive performance and day-to-day functioning in older adults with postviral neurocognitive dysfunction? * Will treatment effects be maintained over time, leading to better long term cognitive outcomes? * Does the treatment lead to reductions in blood-based markers of inflammation as a potential mechanism of cognitive symptom improvement? * Can the treatment be optimized and refined based on feedback from participants to improve user (patient) experience? Researchers will compare the computerized cognitive remediation program to an active computer-based control condition (alternative computer activities) to see if the computerized cognitive remediation program works to treat postviral neurocognitive dysfunction. Participation takes approximately 43-48 hours over 7 months, with most activities (40-46 hours) completed within the first 7-8 weeks, including: * Initial intake visit: Eligibility confirmation (\~2-3 hours) * Computer activities: About 5 hours per week for \~6 weeks (total \~30 hours) completed on a computer tablet provided by the study and loaned to participants for use during the treatment phase * Weekly remote check-in meetings: \~30 minutes each during treatment * Blood draws: Two sessions (before and after treatment), \~20-30 minutes each * Three research visits: Pre-treatment, post-treatment, and 6-month follow-up (\~2-3 hours each, including assessments of cognitive, emotional, and daily functioning)

Waitlist Available
Has No Placebo

UConn Health

Cutter Lindbergh, Ph.D.

Image of Department of Nutritional Sciences in Storrs, United States.

Freeze-dried Grape Powder for Healthy Aging

50 - 75
All Sexes
Storrs, CT

The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, and metabolism that are known to change with aging. Grapes contain several nutrients and antioxidant polyphenols such as resveratrol, quercetin, vitamin K and fiber, which are known to promote heart and immune health. However, the effects of grapes on altering immune profiles within the context of aging is not well understood. Therefore, this study will explore how daily grape consumption impacts certain markers of immunity in healthy middle- and older-aged adults. The main study procedures include consumption of a freeze-dried grape powder and control powder (which tastes the same but has none of the grape compounds that are being studied) mixed with water as a beverage on a daily basis for 4 weeks each. The investigators will additionally ask that participants avoid eating grapes and certain other antioxidant/grape-related foods and beverages throughout the 13-week study. Participants will additionally be asked to complete surveys about their diet, physical activity, and medical history, as well as provide blood samples and body weight measures throughout the course of the study. Participation in the study is expected to last about 6.25 hours over the course of 13 weeks and will include 7 visits.

Recruiting
Paid Trial

Department of Nutritional Sciences

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Image of Abcentra Investigational Site in Los Angeles, United States.

Orticumab for Heart Attack

18+
All Sexes
Los Angeles, CA

The goal of this clinical trial is to determine the clinical effect of orticumab treatment on inflammation in study participants with prior myocardial infarction who have elevated coronary inflammation based on CCTA. The main question it aims to answer is: Clinical effects of orticumab treatment on inflammation of the coronary artery parameters measured with CCTA Researchers will compare the effects with placebo group after 6 months of treatment Participants will Keep the planned study visit appointments Provide complete information about medical and medical history Speak to the study doctor before changing any of non-study treatments, including starting new medications, receiving any vaccinations, or setting out to join any other clinical studies

Phase 2
Recruiting

Abcentra Investigational Site (+6 Sites)

Abcentra

Image of School of Public Health in Bloomington, United States.

High Salt Intake for High Blood Pressure

60 - 85
All Sexes
Bloomington, IN

Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumption being associated with increased risk for chronic kidney disease and cardiovascular disease, the leading cause of death in America. Salt is particularly deleterious in older adults who are more likely to exhibit salt-sensitive hypertension. However, salt consumption remains high in the United States. Thus, there is a critical need for strategies to counteract the effects of high dietary salt as consumption is likely not going to decrease. One promising option is ketones, metabolites that are produced in the liver during prolonged exercise and very low-calorie diets. While exercise and low-calorie diets are beneficial, not many people engage in these activities. Limited evidence indicates that ketone supplements improve cardiovascular health in humans. Additionally, published rodent data indicates that ketone supplements prevent high salt-induced increases in blood pressure, blood vessel dysfunction, and kidney injury. Our human pilot data also indicates that high dietary salt reduces intrinsic ketone production, but it is unclear whether ketone supplementation confers humans' protection against high salt similar to rodents. Therefore, the investigators seek to conduct a short-term high-dietary salt study to determine whether ketone supplementation prevents high dietary salt from eliciting increased blood pressure, blood vessel dysfunction, and kidney injury/impaired blood flow. The investigators will also measure inflammatory markers in blood samples and isolate immune cells that control inflammation. Lastly, the investigators will also measure blood ketone concentration and other circulating metabolites that may be altered by high salt, which could facilitate novel therapeutic targets to combat high salt.

Recruiting
Has No Placebo

School of Public Health

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