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Behavioral Intervention

Contingency Management for HIV and Stimulant Use Disorder (CoMBo Trial)

N/A
Waitlist Available
Led By Ayesha Appa, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Living with HIV or at risk for HIV
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up interviews performed within 6 months of intervention participation.
Awards & highlights

Summary

This trial aims to test a method called contingency management to reduce methamphetamine use and improve adherence to HIV medications. They will use urine tests to track progress in real-time and evaluate the effectiveness of this approach

Who is the study for?
This trial is for individuals with HIV who also struggle with stimulant use, specifically methamphetamine. Participants should be currently using methamphetamines and have difficulty sticking to their antiretroviral therapy (ART) for HIV. The study excludes details on specific inclusion or exclusion criteria.
What is being tested?
The study tests a strategy called contingency management, which rewards patients for reducing methamphetamine use and improving adherence to HIV medication. It uses real-time urine tests to monitor progress and hair analysis to measure long-term changes in drug use.
What are the potential side effects?
Since the intervention involves behavioral incentives rather than medications, traditional side effects are not applicable. However, participants may experience stress or anxiety related to meeting the requirements for incentives.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am living with HIV or at high risk for HIV.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~interviews performed within 6 months of intervention participation.
This trial's timeline: 3 weeks for screening, Varies for treatment, and interviews performed within 6 months of intervention participation. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Acceptability: in-depth interviews with participants, staff
Feasibility: proportion of CM visits attended
Secondary study objectives
Effectiveness (Hair)
Effectiveness (Urine)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Contingency management armExperimental Treatment1 Intervention
Participants are offered once weekly contingency management in clinic to support reduced stimulant use and HIV medication adherence.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Contingency management
2006
Completed Phase 4
~1020

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,551 Previous Clinical Trials
15,257,849 Total Patients Enrolled
Ayesha Appa, MDPrincipal InvestigatorUniversity of California, San Francisco
~18 spots leftby Sep 2025
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