Lysodren

Adrenocortical Carcinoma, Cushing's Syndrome
Treatment
1 FDA approval
1 Active Study for Lysodren

What is Lysodren

MitotaneThe Generic name of this drug
Treatment SummaryMitotane is a medication derived from an insecticide used to treat adrenocortical tumors. It works by blocking the production of hormones in the adrenal cortex. Although it has been known to cause damage to the central nervous system, it does not affect the bone marrow.
Lysodrenis the brand name
image of different drug pills on a surface
Lysodren Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lysodren
Mitotane
2009
2

Approved as Treatment by the FDA

Mitotane, also known as Lysodren, is approved by the FDA for 1 uses which include Adrenocortical Carcinoma .
Adrenocortical Carcinoma

Effectiveness

How Lysodren Affects PatientsMitotane is a medicine used to treat cancer of the adrenal glands. It changes the way the body processes cortisol, a hormone released by the adrenal glands, and can stop the cancerous cells from growing without completely destroying them. It makes the body produce more of a certain kind of cortisol, which lowers levels of other types of cortisol.
How Lysodren works in the bodyWe don't know exactly how it works, but studies suggest this drug alters how your body processes hormones and reduces activity in the adrenal cortex.

When to interrupt dosage

The recommended dosage of Lysodren is determined by the determined condition. The amount varies, contingent upon the method of delivery featured in the table below.
Condition
Dosage
Administration
Adrenocortical Carcinoma
, 500.0 mg
, Oral, Tablet, Tablet - Oral
Cushing's Syndrome
, 500.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Lysodren has one contraindication and should not be taken in tandem with the ailments listed in the following table.Lysodren Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Lysodren.
Common Lysodren Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Mitotane.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Mitotane.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Mitotane.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be increased when combined with Mitotane.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Mitotane.
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Lysodren Novel Uses: Which Conditions Have a Clinical Trial Featuring Lysodren?

Two ongoing clinical trials are investigating the potential of Lysodren in providing therapeutic relief from Cushing's Syndrome.
Condition
Clinical Trials
Trial Phases
Adrenocortical Carcinoma
0 Actively Recruiting
Cushing's Syndrome
1 Actively Recruiting
Phase 2

Lysodren Reviews: What are patients saying about Lysodren?

5Patient Review
5/16/2008
Lysodren for Cushing's Syndrome
This medication has been prescribed for my Llaso Apso who was diagnosed with Cushing's Disease. The treatment has been working and he has not experienced, so far, any extreme side effects from the medication. He is a 13 year old canine, and has been on this medication for one year now.
5Patient Review
12/1/2009
Lysodren for Cushing's Syndrome
I've been very happy with this treatment for my dog. She's been on it for over a year now with no problems.
5Patient Review
8/17/2013
Lysodren for Cushing's Syndrome
My Boston Terrier has been on lysodren for a few months to treat cushings, and she's had no negative side effects so far. The only thing is that she gets a little drowsy.
4Patient Review
5/9/2009
Lysodren for Cushing's Syndrome
We used this on our dog for cushings and it worked well.
3.7Patient Review
12/28/2009
Lysodren for Cushing's Syndrome
My cocker spaniel has been on this medication for less than a year and has experienced some of the common side effects, such as drowsiness and loss of appetite. She also has atypical Cushing's which requires us to medicate with melatonin. This is likely adding to her drowsiness.
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Patient Q&A Section about lysodren

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Lysodren used for?

"Lysodren is an anticancer medication used to treat cancer of the adrenal gland."

Answered by AI

What are side effects of mitotane?

"If you experience any of the following side effects, you should call your doctor: darkening of the skin, dizziness or lightheadedness, mental depression, nausea or vomiting, skin rash."

Answered by AI

What is Lysodren used for in dogs?

"Mitotane is an anticancer medication that is toxic to adrenal gland cells and is used to treat hyperadrenocorticism (Cushing's disease) or adrenal gland carcinoma. Its use in dogs and ferrets to treat adrenal disorders is 'off label' or 'extra label'."

Answered by AI

Is Lysodren a chemotherapy drug?

"Mitotane is a chemotherapy drug used to treat adrenal gland cancer. It may also be called Lysodren."

Answered by AI

Clinical Trials for Lysodren

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