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What is Prolixin Decanoate
FluphenazineThe Generic name of this drug
Treatment SummaryFluphenazine is a type of anti-psychotic medication used to treat mental disorders such as psychosis. It works in a similar way to chlorpromazine and helps to reduce symptoms such as hallucinations, delusions, and anxiety.
Fluphenazine Hydrochlorideis the brand name
Prolixin Decanoate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fluphenazine Hydrochloride
Fluphenazine
1987
181
Approved as Treatment by the FDA
Fluphenazine, also known as Fluphenazine Hydrochloride, is approved by the FDA for 1 uses including Schizophrenia .Schizophrenia
Helps manage Psychosis
Effectiveness
How Prolixin Decanoate Affects PatientsFluphenazine is a drug used to treat schizophrenia and other psychotic disorders. It has not been found to help with managing behavioral problems in people with mental disabilities.
How Prolixin Decanoate works in the bodyFluphenazine works on the brain to reduce activity. It blocks receptors that are responsible for stimulating nerve cells. This has effects on the hormones released by the hypothalamus and pituitary gland, as well as on the reticular activating system, which affects basic metabolism, body temperature, wakefulness, and other functions.
When to interrupt dosage
The suggested dosage of Prolixin Decanoate is contingent upon the identified disorder, such as Schizophrenia, Gilles de la Tourette's Syndrome and Sedation therapy. The amount of dosage differs, as per the delivery approach (e.g. Tablet, film coated - Oral or Intramuscular) catalogued in the following table.Condition
Dosage
Administration
Sedation therapy
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Schizophrenia
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Depression
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Tourette Syndrome
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Chorea
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Sedation
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Huntington Disease
, 5.0 mg/mL, 0.5 mg/mL, 2.5 mg, 5.0 mg, 10.0 mg, 1.0 mg, 25.0 mg/mL, 2.5 mg/mL, 2.0 mg, 125.0 mg/mL, 100.0 mg/mL
, Oral, Solution, concentrate, Solution, concentrate - Oral, Elixir, Elixir - Oral, Tablet, film coated, Tablet, film coated - Oral, Intramuscular; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Subcutaneous, Tablet, Tablet - Oral, Intramuscular, Injection, solution - Intramuscular, Liquid, Liquid - Intramuscular; Subcutaneous, Liquid - Intramuscular, Solution, Solution - Intramuscular; Subcutaneous, Injection, Injection - Intramuscular; Subcutaneous
Warnings
Prolixin Decanoate ContraindicationsCondition
Risk Level
Notes
Brain Injuries
Do Not Combine
Disease
Do Not Combine
Liver Damage
Do Not Combine
Mental Depression
Do Not Combine
Hypnotics
Do Not Combine
Brain Injuries
Do Not Combine
Comatose
Do Not Combine
Common Prolixin Decanoate Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Fluphenazine may increase the antipsychotic activities of Amisulpride.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Fluphenazine.
Azelastine
Major
Fluphenazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Fluphenazine.
Deutetrabenazine
Major
The risk or severity of adverse effects can be increased when Fluphenazine is combined with Deutetrabenazine.
Prolixin Decanoate Novel Uses: Which Conditions Have a Clinical Trial Featuring Prolixin Decanoate?
640 active clinical trials are investigating the potential of Prolixin Decanoate to mitigate Huntington Disease, Sedation therapy and Chorea.Condition
Clinical Trials
Trial Phases
Sedation therapy
0 Actively Recruiting
Sedation
2 Actively Recruiting
Phase 3, Not Applicable
Tourette Syndrome
0 Actively Recruiting
Depression
330 Actively Recruiting
Phase 1, Phase 2, Early Phase 1, Not Applicable, Phase 4, Phase 3
Huntington Disease
10 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable
Chorea
0 Actively Recruiting
Schizophrenia
37 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Prolixin Decanoate Reviews: What are patients saying about Prolixin Decanoate?
5Patient Review
3/3/20085Patient Review
9/29/2015 This shot has made a world of difference for my mother and our family. We stopped all her other medications and now only use this one every four weeks.
4.3Patient Review
8/14/2014 When I first got this injection, it was like a huge weight had been lifted off of me. It really worked wonders for me and helped immensely. The only downside is that you have to take another medication to counteract the side effects, which causes terrible dry mouth.
3Patient Review
5/25/2011 I've used this for 10 years to manage my illness, but now that I have early onset Alzheimer's, I wonder if it is still safe for me to take.
1Patient Review
5/29/2012 Prolixin Decanoate Inj caused neuroleptic malignant syndrome which resulted in paralysis. I'm lucky to be alive after just one injection of this stuff.
Patient Q&A Section about prolixin decanoate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How do you administer fluphenazine?
"This medication is typically given as a deep intramuscular injection into the buttock area, usually at doses of 12.5 mg to 100 mg, given every two to five weeks."
Answered by AI
What is prolixin decanoate used for?
"This fluphenazine medication works for long periods of time to treat mental and mood problems like chronic schizophrenia."
Answered by AI
How do I start prolixin decanoate?
"Initiation: 6.25 mg IM
Dose adjustments: 6.25 to 12.5 mg increments every two weeks until the target dose is reached."
Answered by AI
What is the side effect of prolixin?
"you may experience: drowsiness, lethargy, dizziness, lightheadedness, nausea, loss of appetite, sweating, dry mouth, blurred vision, headache, and constipation. If you have any of these symptoms, tell your doctor or pharmacist. Dizziness and lightheadedness can make you more likely to fall."
Answered by AI