Ubrelvy

Migraine with Aura, Migraine without Aura

Treatment

4 Active Studies for Ubrelvy

What is Ubrelvy

Ubrogepant

The Generic name of this drug

Treatment Summary

Ubrogepant is a medication used to treat migraine headaches in adults. It was approved by the FDA in December 2019 and is the first oral drug of its kind to be used for the acute treatment of migraines. Compared to current treatments like triptans, ubrogepant is better tolerated, does not cause medication overuse headaches, and has no cardiovascular risk, making it suitable for patients with cardiovascular disease. This drug may become the new standard of therapy for the treatment of migraine headaches.

Ubrelvy

is the brand name

image of different drug pills on a surface

Ubrelvy Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ubrelvy

Ubrogepant

2019

2

Effectiveness

How Ubrelvy Affects Patients

Ubrogepant relieves migraine headache pain by preventing a certain chemical from being active. People with severe liver or kidney problems may need to take a lower dose of ubrogepant and it is not recommended for those with end-stage kidney disease.

How Ubrelvy works in the body

Ubrogepant is a drug used to treat migraine headaches. It works by blocking the action of calcitonin gene-related peptide (CGRP), a molecule that helps the body create pain signals. CGRP is released during migraine attacks and binds to receptors in the trigeminal ganglion, a network of nerves that send pain signals to the brain. By blocking the action of CGRP, Ubrogepant stops the body from amplifying and perpetuating the migraine headache pain, ultimately stopping the headache.

When to interrupt dosage

The prescribed amount of Ubrelvy is contingent upon the diagnosed condition. The exact dosage depends on the mode of delivery, noted in the following table.

Condition

Dosage

Administration

Migraine with Aura

50.0 mg, , 100.0 mg

, Tablet - Oral, Tablet, Oral

Migraine without Aura

50.0 mg, , 100.0 mg

, Tablet - Oral, Tablet, Oral

Warnings

Ubrelvy Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Ubrelvy.

Common Ubrelvy Drug Interactions

Drug Name

Risk Level

Description

Axitinib

Moderate

The serum concentration of Axitinib can be increased when it is combined with Ubrogepant.

Belantamab mafodotin

Moderate

The serum concentration of Belantamab mafodotin can be increased when it is combined with Ubrogepant.

Bendamustine

Moderate

The serum concentration of Bendamustine can be increased when it is combined with Ubrogepant.

Binimetinib

Moderate

The serum concentration of Binimetinib can be increased when it is combined with Ubrogepant.

Bortezomib

Moderate

The serum concentration of Bortezomib can be increased when it is combined with Ubrogepant.

Ubrelvy Toxicity & Overdose Risk

Not much is known about the toxicity of ubrogepant, so it is recommended that those who overdose be monitored for at least 24 hours, since the drug has a half-life of 5 to 7 hours.

image of a doctor in a lab doing drug, clinical research

Ubrelvy Novel Uses: Which Conditions Have a Clinical Trial Featuring Ubrelvy?

4 active trials are currently underway to investigate the potential of Ubrelvy in addressing Migraine Without Aura.

Condition

Clinical Trials

Trial Phases

Migraine with Aura

0 Actively Recruiting

Migraine without Aura

4 Actively Recruiting

Not Applicable, Phase 4

Ubrelvy Reviews: What are patients saying about Ubrelvy?

5

Patient Review

1/11/2021

Ubrelvy for Migraine Headache

I was worried that this medication would make me nauseous, but it didn't. Not only that, but it worked quickly and completely got rid of my migraine. I've been suffering from chronic migraines for 30 years and have tried all kinds of medications with poor results. The first time I tried Ubrelvy I was already on day 2 of my migraine and it still worked!

5

Patient Review

8/9/2020

Ubrelvy for Migraine Headache

Even though it takes a little bit for this medication to work, it's really amazing. In most cases, my migraines were completely gone within two hours.

5

Patient Review

11/18/2020

Ubrelvy for Migraine Headache

I am thoroughly impressed with this medication. I've been struggling with migraines and vertigo for over 20 years, and this is the first time I've found something that can actually stop a vertigo attack in its tracks.

5

Patient Review

6/4/2021

Ubrelvy for Migraine Headache

This medication completely alleviated all of my chronic pain, including migraines and neck/eye pain. No side effects that I could tell, other than the fact that it's quite expensive.

5

Patient Review

11/18/2021

Ubrelvy for Migraine Headache

This medication works incredibly fast, within two hours for the majority of my headaches. The only downside is a very slight drowsiness; however, it is well worth it for the relief it provides. Additionally, coupons make this drug very affordable.

5

Patient Review

1/26/2022

Ubrelvy for Migraine Headache

This drug is really a lifesaver. It quickly and effectively gets rid of my headaches with no negative side effects. I've recommended it to other people who also suffer from migraines, and they've all had great results as well.

5

Patient Review

5/17/2022

Ubrelvy for Migraine Headache

Ubrelvy has given me my life back. I had migraines for 30 years and tried everything with no avail--until this medication. It's a near miracle how well it works; almost every time, with very few side effects (just a bit of drowsiness). If only insurance would cover more than 9 per month!

5

Patient Review

7/1/2022

Ubrelvy for Migraine Headache

This medication is extremely effective for me in treating migraines. I don't experience any negative side effects, which is wonderful. Additionally, I appreciate that it comes in single-use packaging--it's easy to keep on hand wherever I might need it.

3.3

Patient Review

9/8/2020

Ubrelvy for Migraine Headache

I've had migraines for 25 years and have tried all the Triptans. Maxalt was loosing its effectiveness so MD gave me Ubrevly to try. I can't say it doesn't work, it does. BUT I get awful nausea from it and debilitating fatigue. Even after the nausea subsides, I'm still too tired to function during the day. This is my experience, the drug works well, after 1 hr or so. So I recommend trying it if you have insurance to cover the cost.

2.3

Patient Review

3/19/2022

Ubrelvy for Migraine Headache

I was really hopeful for this medication, as my other options are limited due to high blood pressure. Unfortunately, it didn't work at all for me.

2.3

Patient Review

9/14/2022

Ubrelvy for Migraine Headache

I had high hopes for this new migraine medication, but unfortunately it did not work for me. I got very hot, flushed, and nauseous about an hour after taking it, and my migraines were actually worse.

2.3

Patient Review

11/7/2022

Ubrelvy for Migraine Headache

I've been diagnosed with vestibular migraines for three years now, and I've tried this medication a few times. Unfortunately, it has made my migraines worse on five out of seven occasions. It gives me a piercing headache and makes my head feel tight. I also usually start feeling nauseous.

1

Patient Review

12/20/2020

Ubrelvy for Migraine Headache

I tried this medication for migraines, but not only did it not help at all, it also caused me stomach pain.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ubrelvy

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is UBRELVY prescribed for?

"Ubrogepant is a medication used to treat migraines which may work by changing the amount of a certain natural substance in the brain. It is effective in relieving headaches, pain, and other symptoms associated with migraines such as nausea, vomiting, and sensitivity to light and sound."

Answered by AI

What are side effects of UBRELVY?

"You may experience heart problems, such as changes in blood pressure, numbness or tingling in your extremities, or difficulty sleeping."

Answered by AI

Is UBRELVY only for migraines?

"Ubrelvy is a medication used to treat migraine symptoms in adults. It is not meant to be used in children, and it cannot prevent migraine symptoms. Symptoms of migraine include severe headaches, nausea, vomiting, and visual or sensory changes called an aura."

Answered by AI

Is UBRELVY a narcotic?

"Ubrelvy is non-narcotic, not scheduled, and does not have addiction potential. It is available in two doses (50 mg and 100 mg) and is designed to allow healthcare providers to tailor treatment to the needs of individual patients."

Answered by AI

Clinical Trials for Ubrelvy

Image of University of California, Irvine Medical Center ENT Clinic (Pavilion 2) in Orange, United States.

Migraine Medications for Tinnitus

25 - 85
All Sexes
Orange, CA

Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life. Despite too many research projects on finding the mechanism of tinnitus, its pathophysiology remains poorly understood. It is well understood that many factors, such as poor education, lower income, or occupational, and recreational activity associated with high noise exposure, influence the prevalence and risk of tinnitus. Although the economic and emotional impact of tinnitus is large, there is currently no FDA-approved medication to treat this condition. However, there are pharmacological options to address the stress, anxiety, and depression that are caused by tinnitus. In this project, the investigators intend to use medications for patients with acute tinnitus to decrease the impact of tinnitus in their daily lives and activities. There are some studies on medications treating tinnitus; however, there are few randomized clinical trials to prove the efficacy of the treatment. The frequency and loudness of tinnitus will be measured before and after the course. Functional MRI of the brain will be obtained to view any changes that may occur before and after the treatment.

Phase 4
Waitlist Available

University of California, Irvine Medical Center ENT Clinic (Pavilion 2)

Mehdi Abouzari, MD, PhD