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Amino Acid Supplement

L-Phenylalanine for Gut Health

Phase < 1

Waitlist Available

Led By Iliyan D Iliev, PhD

Research Sponsored by Weill Medical College of Cornell University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

History of a diagnosis of any gastrointestinal condition, such as inflammatory bowel syndrome or disease

Antifungal usage within the past month

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, week 4 (day 28)

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to investigate how the dietary supplement L-Phenylalanine impacts the levels of phenylpropionic acid (PPA) and the types of fungi in the gut."

Who is the study for?

This trial is for healthy volunteers interested in how a dietary supplement, L-Phenylalanine, might affect their gut health. Specific eligibility criteria are not provided, but typically participants should be free from the conditions being studied and meet any additional requirements set by the researchers.

What is being tested?

The study is testing the effects of a 500 mg L-Phenylalanine capsule on gut fungal populations and production of phenylpropionic acid (PPA) in healthy individuals to understand its potential benefits for gut microbiome health.

What are the potential side effects?

While specific side effects are not listed, dietary supplements like L-Phenylalanine could potentially cause digestive discomfort or allergic reactions in some people.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have been diagnosed with a condition affecting my digestive system.

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I have used antifungal medication in the last month.

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I am not on medications that interact with L-phenylalanine, like MOAI, L-DOPA, or certain antipsychotics.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, week 4 (day 28)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, week 4 (day 28)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 4 (day 28) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Secondary study objectives

Change in fungal population levels, specifically gut Candida levels, from baseline in subject fecal material

Change in phenylpropionic acid levels from baseline in subject fecal material

Change in the number of T cells that react to fungal antigens from baseline in subject blood samples

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: HealthyExperimental Treatment1 Intervention

Participants will receive one bottle of L-Phenylalanine 500 mg Veg Capsule product on Day 0. All subjects will be asked to start taking the supplement on Day 1 continuing until Day 14. They will be asked to take 2x 500 mg capsules in the morning and 1x 500 mg capsule in the evening daily for 14 days.

0 / 3Eligibility criteria met