Noninvasive Brain Stimulation for Carpal Tunnel Syndrome
Trial Summary
What is the purpose of this trial?
The purpose of this study is to assess the effects of tDCS in combination with TUS for the treatment of pain in subjects with Carpal Tunnel Syndrome. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you have used carbamazepine in the past 6 months.
What data supports the effectiveness of the treatment Transcranial Direct Current Stimulation (tDCS) for Carpal Tunnel Syndrome?
Is noninvasive brain stimulation safe for humans?
Transcranial Direct Current Stimulation (tDCS) is generally considered safe for humans, with no severe complications reported at intensities of 4 mA or less for up to 60 minutes per day. Studies show that the amount of electricity used is much lower than levels that could cause permanent brain changes, and adverse effects are usually mild and temporary.678910
How is the treatment of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound (TUS) unique for carpal tunnel syndrome?
This treatment is unique because it uses noninvasive brain stimulation techniques, which are different from traditional methods like surgery or acupuncture. Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound (TUS) aim to modulate brain activity to alleviate symptoms, offering a novel approach compared to other treatments that focus directly on the wrist or nerve.1112131415
Eligibility Criteria
This trial is for adults aged 18-80 with Carpal Tunnel Syndrome causing chronic pain despite previous treatments. Participants must have had pain for at least 6 months, feel it on most days, and rate it at least a 3 out of 10. They can't join if they're pregnant, have used certain medications recently, suffer from major depression or neurological issues like stroke or epilepsy, have metal implants in the brain, or a history of substance abuse.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 20 minutes of active or sham transcranial direct current stimulation (tDCS) and transcranial ultrasound (TUS) for the treatment of pain in Carpal Tunnel Syndrome
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Transcranial Direct Current Stimulation (tDCS) (Behavioural Intervention)
- Transcranial Ultrasound (TUS) (Behavioural Intervention)
Transcranial Direct Current Stimulation (tDCS) is already approved in United States, European Union, Canada, Australia for the following indications:
- Depression
- Stroke rehabilitation
- Chronic pain management
- Research use for various neurological and psychiatric conditions including autism spectrum disorder
- Depression
- Stroke rehabilitation
- Chronic pain management
- Research use for various neurological and psychiatric conditions including autism spectrum disorder
- Depression
- Stroke rehabilitation
- Chronic pain management
- Research use for various neurological and psychiatric conditions including autism spectrum disorder
- Depression
- Stroke rehabilitation
- Chronic pain management
- Research use for various neurological and psychiatric conditions including autism spectrum disorder