Metformin for Atrial Fibrillation

Recruiting in Palo Alto (17 mi)

Overseen byHakan Oral, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: University of Michigan

No Placebo Group

Prior Safety Data

Approved in 6 Jurisdictions

Trial Summary

What is the purpose of this trial?This trial is testing if metformin, a diabetes drug, can help reduce abnormal heart rhythms in patients with atrial fibrillation. By managing blood sugar and insulin response, metformin might lower the risk of these heart issues. Metformin has been shown to have various cardiovascular benefits, including a reduction in stroke, heart failure, and heart attacks.

Eligibility Criteria

This trial is for individuals with a BMI over 25 who are undergoing catheter ablation to manage atrial fibrillation. Participants must understand and agree to the study's terms. Those already on metformin or other diabetes drugs, with known diabetes, severe kidney issues, metabolic acidosis, heavy alcohol use, liver dysfunction, advanced heart failure or who are pregnant/nursing cannot join.

Inclusion Criteria

All subjects must be able to understand and willing to sign a written informed consent document.

My BMI is over 25 and I plan to have a procedure to correct heart rhythm.

Exclusion Criteria

You drink more than two alcoholic drinks every day on average.

I am currently taking medication for fluid build-up.

I am currently taking metformin or other medications for diabetes.

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Participant Groups

The trial tests if metformin can help prevent atrial fibrillation from coming back after an ablation procedure. Patients will either receive no additional treatment or be given metformin alongside standard lifestyle change education. They'll be monitored for up to a year post-ablation.

2Treatment groups

Experimental Treatment

Group I: Standard of careExperimental Treatment2 Interventions

Standard of care ablation with recommendations for lifestyle modification.

Group II: MetforminExperimental Treatment3 Interventions

Standard of care ablation with recommendations for lifestyle modification and metformin.