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fMRI for Brain Cancer

N/A

Waitlist Available

Led By Andrei Holodny, MD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients must be able to perform the language paradigms on cue while inside the scanner

Patients between the ages of 18 and 80 years

Must not have

Volunteers who are unable to perform the language paradigms on cue while inside the scanner (due to weakness, deafness, inability to understand or follow instructions etc.)

Patients who are unable to perform the language paradigms on cue while inside the scanner (due to weakness, deafness, inability to understand or follow instructions etc.)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

No Placebo-Only Group

Summary

This trial will test whether adding an imaging technique called breath-holding functional magnetic resonance imaging (BH fMRI) to the standard approach improves accuracy.

Who is the study for?

This trial is for adults aged 18-80 with brain tumors near areas responsible for speech or movement, who can follow language tasks during an MRI scan. It's not suitable for those with claustrophobia, anxiety preventing MRI exams, pacemakers (unless MRI safe), pregnant/nursing women, and individuals unable to perform required tasks due to physical or cognitive limitations.

What is being tested?

The study tests the accuracy of breath-holding fMRI compared to standard imaging in locating brain functions affected by tumors. Researchers aim to determine if this additional imaging technique provides better results than the current standard alone.

What are the potential side effects?

There are no direct side effects from participating in this trial as it involves non-invasive imaging techniques. However, participants may experience discomfort from lying still inside the scanner and performing specific language paradigms.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can follow language tasks as instructed during a scan.

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I am between 18 and 80 years old.

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I have or might have a brain tumor such as glioma, meningioma, or cancer that has spread to my brain.

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I am between 18 and 80 years old.

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My tumor is located in a specific part of my brain related to speech or movement.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I can follow instructions and perform tasks as asked during a scan.

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I cannot follow instructions or respond to cues due to a condition like weakness or deafness.

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I am currently pregnant or nursing.

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I am currently pregnant or nursing.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Number of patients that have false negative results

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Functional Magnetic Resonance Imaging (fMRI)Experimental Treatment1 Intervention

The interventions for this study are non-invasive. For patients, routine pre-operative MRI that includes task based fMRI and perfusion data acquisition will be performed on a 3T scanner. Patients who participate in this study, will have approximately 5 minutes added to their scan time for the below described breath holding fMRI (BH fMRI) paradigm, which will be done for research purposes. For healthy volunteers, participation will involve having a high resolution anatomical MRI done with the same paradigms which patients will have, listed below. the total scanner time will be approximately 25 minutes, and the scan will not be billed to the healthy volunteer.

0 / 9Eligibility criteria met