Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes

Recruiting in Palo Alto (17 mi)

Overseen byJonathan Little, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of British Columbia

Trial Summary

What is the purpose of this trial?

Ketones are a source of energy and signaling molecule that are produced by the body when not consuming any food or consistently eating a low-carbohydrate "keto" diet. Blood ketones can be used as a source of energy by the body, but they may also act as signals that impact how different cells in the body function. Recently, ketone supplements have been developed that can be consumed as a drink. These supplements can raise blood ketones without having to fast or eat a "keto" diet. Previous studies have shown that these supplement drinks can lower blood sugar without having to make any other dietary changes. Drinking these ketone supplements may therefore be an effective strategy to improve blood sugar control and influence how cells function. To find out if it is feasible for people with type 2 diabetes to drink these ketones supplements regularly over 90 days, we will compare between two groups in this study: one group that will be asked to drink ketone supplements, and one group that will be asked to drink a placebo supplement.

Research Team

Jonathan Little, PhD

Principal Investigator

University of British Columbia

Eligibility Criteria

Inclusion Criteria

diagnosed with type 2 diabetes by a physician at least 1 year prior

stable use of glucose-lowering medications for at least three months

must be able to read and understand English in order to complete the study questionnaires

Exclusion Criteria

You are currently trying to intentionally gain or lose weight.

You have a history of mental illness or currently have a neurological disease.

unable to commit to a 90-day trial

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Treatment Details

Interventions

D-β-hydroxybutyric acid with R-1,3-butanediol (Ketone Supplement)
Inert placebo (Other)

Participant Groups

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Exogenous Ketone SupplementExperimental Treatment1 Intervention

Participants will be instructed to consume a total of 711 mL of the exogenous ketone supplement drink (for a total of 30 g of beta-hydroxybutyrate) per day (3 doses at 237 mL containing 10 g of beta-hydroxybutyrate each) for a period of 90 days.

Group II: Inert placeboPlacebo Group1 Intervention

Participants will be instructed to consume an equivalent volume (711 mL) of taste- and volume-matched placebo per day (3 doses at 237 mL) for 90 days.