Oxytocin Rest for Prolonged Labor (ORCA Trial)

N/A

Recruiting

Led By Matthew K Hoffman

Research Sponsored by Christiana Care Health Services

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

≥18 years of age

Prolonged latent labor, defined as cervical dilation <6cm after ≥8 hours since rupture of membranes and on continuous oxytocin

Must not have

Any contraindication to continuous oxytocin at time of randomization

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from randomization to delivery

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to see if taking a break from oxytocin infusion for 60 minutes during prolonged labor can decrease the chances of cesarean delivery. This break, called 'oxytocin rest

Who is the study for?

This trial is for individuals experiencing prolonged labor or difficult childbirth, specifically when induction methods have failed. To participate, they must have been receiving continuous oxytocin without seeing progress in their labor.

What is being tested?

The study tests 'oxytocin rest,' which means stopping and then restarting oxytocin infusion after an hour to see if it reduces the need for cesarean delivery by improving uterine contractions and labor progress.

What are the potential side effects?

While not explicitly listed, potential side effects may include changes in contraction patterns or intensity, discomfort due to fluctuating labor progression, and possible impacts on fetal heart rate.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Select...

My labor was slow, with less than 6cm dilation after 8 hours of my water breaking and being on oxytocin.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I cannot receive oxytocin due to health reasons.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from date of delivery to date of hospital discharge for neonate (or up to 28 days of life)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from date of delivery to date of hospital discharge for neonate (or up to 28 days of life)

This trial's timeline: 3 weeks for screening, Varies for treatment, and from date of delivery to date of hospital discharge for neonate (or up to 28 days of life) for reporting.