Kidney Transplantation for HIV

N/A

Recruiting

Led By Christine Durand, MD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Participant is able to understand and provide informed consent

Participant is ≥ 18 years old

Must not have

Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis of > 1 month, or primary central nervous system (CNS) lymphoma

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from transplant through end of follow up (at least 1 year, up to 4 years post-transplant)

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to study rejection in HIV-positive transplant recipients who receive kidneys from donors with or without HIV to improve understanding of the process. "This trial aims to study how rejection occurs in HIV-positive transplant

Who is the study for?

This trial is for adults over 18 with HIV who need a kidney transplant. They must have low levels of HIV in their blood, be generally healthy without significant weight loss from HIV, and meet local transplant criteria. People can't join if they're pregnant, breastfeeding, or have certain serious health issues like brain infections or lymphoma.

What is being tested?

The study compares the outcomes of kidney transplants in people with HIV receiving kidneys from donors with and without HIV. It aims to understand how donor status affects organ rejection and long-term health after transplantation.

What are the potential side effects?

While specific side effects are not listed here, typical risks associated with kidney transplants may include infection risk due to immunosuppression, possible organ rejection, medication side effects, and complications related to surgery.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I understand the study and can give my consent.

Select...

I am 18 years old or older.

Select...

I am eligible for a kidney transplant according to local guidelines.

Select...

My BMI is 21 or above and I don't have significant weight loss due to HIV.

Select...

My CD4+ T-cell count is 200 or more.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have had PML, long-term cryptosporidiosis, or brain lymphoma.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from transplant through end of follow up (at least 1 year, up to 4 years post-transplant)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from transplant through end of follow up (at least 1 year, up to 4 years post-transplant)

This trial's timeline: 3 weeks for screening, Varies for treatment, and from transplant through end of follow up (at least 1 year, up to 4 years post-transplant) for reporting.