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Behavioural Intervention

Portable Air Cleaners for High Blood Pressure (AirPressureNYC Trial)

N/A

Recruiting

Led By Jonathan Newman

Research Sponsored by NYU Langone Health

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

Lung disease requiring oxygen

History of major known arrhythmias (e.g. atrial flutter or fibrillation, ventricular tachycardia)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to day 180

Summary

This trial will assess if using portable air cleaners can reduce PM2.5 air pollution and lower blood pressure, which is a leading global cause of death.

Who is the study for?

This trial is for non-smoking adults with hypertension living in NYC public housing who don't have severe high blood pressure, major arrhythmias, cardiovascular disease, lung disease requiring oxygen, end-stage renal disease or cancer under treatment. They shouldn't plan to travel out of NYC for long periods or change their medication soon.

What is being tested?

The study tests if portable air cleaners (PACs) can reduce indoor fine particulate matter and lower systolic blood pressure. Participants will be randomly assigned to use either an active PAC that filters the air or a sham PAC that does not work but looks identical.

What are the potential side effects?

Since this trial involves using portable air cleaners rather than medications, there are no direct side effects from drugs. However, participants may experience placebo effects or discomfort due to changes in indoor air quality.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I need oxygen for my lung condition.

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I have a history of serious heart rhythm problems.

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I have a diagnosed heart condition.

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I have severe kidney disease or am on dialysis.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to day 180

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to day 180

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to day 180 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 30 Days

Secondary study objectives

Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 180 Days

Average Self-Measured Morning Home Systolic Blood Pressure (AM H-SBP) over 90 Days

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active Portable Air Cleaner (PAC)Experimental Treatment1 Intervention

Using a double-blind randomized process, active PACs (with HEPA filters inside) will be assembled and placed in the bedroom of study participants. Initiation of the PAC devices will occur at baseline on Day 0. After completion of enrollment, consent and the placement of PACs, electricity monitors, and PurpleAir monitoring, the PAC will be turned on. Participants will be instructed to keep the PACs on in bedrooms during the study duration, closing bedroom doors at night and during the day, when possible. The PAC will run for 24 hours on Day 0 of the study protocol before the 30-day treatment period begins. A kilowatt meter will be installed with the PAC to monitor electricity usage as a measure of adherence.

Group II: Sham PACPlacebo Group1 Intervention

Using a double-blind randomized process, sham PACs (with no filters inside) will be assembled and placed in the bedroom of study participants. Initiation of the PAC devices will occur at baseline on Day 0. After completion of enrollment, consent and the placement of PACs, electricity monitors, and PurpleAir monitoring, the PAC will be turned on. Participants will be instructed to keep PACs on in bedrooms during the study duration, closing bedroom doors at night and during the day, when possible. The PAC will run for 24 hours on Day 0 of the study protocol before the 30-day treatment period begins. A kilowatt meter will be installed with the PAC to monitor electricity usage as a measure of adherence.

0 / 4Eligibility criteria met