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Staged vs Simultaneous Knee Replacement for Osteoarthritis

Montréal, Canada
N/A
Waitlist Available
Led By Eric R. Bohm, MD
Research Sponsored by Orthopaedic Innovation Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients considering bilateral knee arthroplasty
Be older than 18 years old
Must not have
Patients who require simultaneous bilateral knee replacement surgery in order to manage significant bilateral flexion or valgus knee contractures where staged procedures may result in suboptimal outcomes by increasing the risk of post-operative flexion contracture in the 'first replaced' knee
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights
No Placebo-Only Group

Summary

This trial will help answer the question of whether it is better to have both knees replaced at the same time or to do one and wait to do the second one.

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Who is the study for?
This trial is for individuals considering bilateral knee arthroplasty, who are able to sign a consent form and willing to complete study questionnaires. It's not suitable for those unable to fill out the questionnaires or who need simultaneous surgery due to severe knee contractures.Check my eligibility
What is being tested?
The study aims to determine whether it's better for patients with osteoarthritis to have both knees replaced at once (simultaneous) or one at a time (staged). Participants will be assigned one of these two surgical approaches.See study design
What are the potential side effects?
Potential side effects from either surgical approach may include pain, swelling, infection risk, blood clots, stiffness in the knee joint, and complications related to anesthesia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am considering surgery for both of my knees.
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Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I need both knees replaced at the same time due to severe knee issues.
 show original

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Veterans Rand 12-item Health Survey Score (VR-12)
Secondary study objectives
Complications
Costs of knee replacement surgery
Hospital stay
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Unicompartmental Knee Arthroplasty (UKA)Active Control2 Interventions
Patient will have half-knee replacement (partial) - Simultaneous vs Staged
Group II: Total Knee Arthroplasty (TKA)Active Control2 Interventions
Patient will have complete replacement - Simultaneous vs Staged

Find a Location

Closest Location:McGill University· Montréal, Canada

Who is running the clinical trial?

Orthopaedic Innovation CentreLead Sponsor
6 Previous Clinical Trials
446 Total Patients Enrolled
3 Trials studying Osteoarthritis
215 Patients Enrolled for Osteoarthritis
Eric R. Bohm, MDPrincipal InvestigatorUniversity of Manitoba

Media Library

Simultaneous Knee Arthroplasty (UKA) Clinical Trial Eligibility Overview. Trial Name: NCT03564730 — N/A
Osteoarthritis Research Study Groups: Unicompartmental Knee Arthroplasty (UKA), Total Knee Arthroplasty (TKA)
Osteoarthritis Clinical Trial 2023: Simultaneous Knee Arthroplasty (UKA) Highlights & Side Effects. Trial Name: NCT03564730 — N/A
Simultaneous Knee Arthroplasty (UKA) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03564730 — N/A
~17 spots leftby Nov 2025
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