Deep Brain Stimulation for Movement Disorders
Trial Summary
The trial protocol does not specify if you need to stop taking your current medications. However, it mentions that participants should have an unsatisfactory response to their current medical management, which might imply some changes could be necessary. It's best to discuss your specific medications with the study doctors.
Deep Brain Stimulation (DBS) is shown to be highly effective for treating movement disorders like essential tremor, Parkinson's disease, and dystonia. Studies indicate that DBS can reduce tremor severity by about 50% and improve motor symptoms and quality of life significantly in patients with these conditions.
12345Deep Brain Stimulation (DBS) is generally well-tolerated, but it can have complications such as infections (2-16.2%), bleeding in the brain (1-6.3%), and seizures (1-3%). Some patients may need additional surgery to fix or remove the device if problems occur.
678910Deep Brain Stimulation (DBS) is unique because it uses electrical impulses to modulate specific brain regions in a reversible and adjustable way, unlike other treatments that may involve permanent changes or medications. It is particularly effective for advanced movement disorders like Parkinson's disease, essential tremor, and dystonia, offering an option when medications are no longer effective.
23111213Eligibility Criteria
This trial is for adults over 18 with Parkinson's Disease (PD), essential tremor (ET), or certain dystonias who've had a good response to dopaminergic meds for PD. It's not suitable for those with significant medical risks, secondary movement disorders, dementia, pregnancy, psychiatric issues, or an inability to undergo MRI scans.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Surgery and Initial Programming
Eligible participants will have DBS surgery. Study doctors will see participants 3-4 weeks after surgery to turn on the neurostimulator.
Follow-up
Participants will return every month for 3 months, then every 3 months during the first year, and every 6 months during the second year. Each time, participants will be examined and answer questions. DBS placement will be evaluated with MRI. The neurostimulator will be programmed.
Long-term Follow-up
Participants have the option to transfer their care back to the neurologists in the community or continue care with the NIH Neurology team until care in the community is available.
Participant Groups
Deep Brain Stimulation is already approved in United States, European Union, Canada for the following indications:
- Essential tremor
- Parkinson's disease
- Dystonia
- Obsessive-compulsive disorder
- Epilepsy
- Chronic pain
- Stroke-related motor deficits (under investigation)
- Essential tremor
- Parkinson's disease
- Dystonia
- Obsessive-compulsive disorder
- Epilepsy
- Chronic pain
- Essential tremor
- Parkinson's disease
- Dystonia
- Obsessive-compulsive disorder
- Epilepsy
- Chronic pain