TMS + taVNS for Stroke Recovery

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Medical University of South Carolina

No Placebo Group

Trial Summary

What is the purpose of this trial?

Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity. We investigate whether combination of TMS and taVNS is more effective at motor cortex excitability than either modality alone.

Eligibility Criteria

This trial is for adults aged 18-80 in good health who have had a stroke and are looking to improve their motor skills. It's not suitable for those with seizure disorders, pregnant women, people with metal implants above the neck, or individuals taking certain medications like psychotropics or seizure reducers.

Inclusion Criteria

I am between 18 and 80 years old.

You are in good health.

Exclusion Criteria

I am currently on medication to control seizures.

You have a problem with using drugs or being addicted to them, except for nicotine and caffeine.

You have metal implants in your head or neck.

Participant Groups

The study tests if using Transcranial Magnetic Stimulation (TMS) together with transcutaneous auricular vagus nerve stimulation (taVNS) can better enhance motor cortex excitability in stroke recovery than using each method separately.

Group I: Active taVNS, Active TMS Active Control 2 Interventions

Group II: Sham taVNS, Sham TMS Placebo Group 2 Interventions

Group III: Active taVNS, Sham TMS Placebo Group 2 Interventions

Group IV: Sham taVNS, Active TMS Placebo Group 2 Interventions

Transcranial Magnetic Stimulation is already approved in United States, Canada, European Union for the following indications:

🇺🇸 Approved in United States as Transcranial Magnetic Stimulation for:

• Major Depressive Disorder
• Obsessive Compulsive Disorder

🇨🇦 Approved in Canada as Transcranial Magnetic Stimulation for:

• Major Depressive Disorder

🇪🇺 Approved in European Union as Transcranial Magnetic Stimulation for:

• Major Depressive Disorder

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Medical University of South Carolina Charleston, SC

Who Is Running the Clinical Trial?

Medical University of South Carolina Lead Sponsor

National Institutes of Health (NIH) Collaborator

References