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Butler Hospital
Claim this profileProvidence, Rhode Island 02906
Global Leader in Alzheimer's Disease
Global Leader in Depression
Conducts research for Major Depressive Disorder
Conducts research for Suicide
Conducts research for Dementia
155 reported clinical trials
10 medical researchers
Summary
Butler Hospital is a medical facility located in Providence, Rhode Island. This center is recognized for care of Alzheimer's Disease, Depression, Major Depressive Disorder, Suicide, Dementia and other specialties. Butler Hospital is involved with conducting 155 clinical trials across 86 conditions. There are 10 research doctors associated with this hospital, such as Edward Huey, MD, Meghan Riddle, MD, Brandon Gaudiano, PhD, and Stephen Salloway, MD.Area of expertise
1Alzheimer's Disease
Global LeaderAPP positive
PSEN1 positive
PSEN2 positive
2Depression
Global LeaderTop PIs
Edward Huey, MDColumbia University Medical Center6 years of reported clinical research
Studies Pick's Disease
Studies Primary Progressive Aphasia
8 reported clinical trials
9 drugs studied
Meghan Riddle, MDButler Hospital1 year of reported clinical research
Studies Alzheimer's Disease
Studies Mild Cognitive Impairment
6 reported clinical trials
13 drugs studied
Brandon Gaudiano, PhDButler Hospital5 years of reported clinical research
Studies Suicide
Studies Suicide Prevention
4 reported clinical trials
6 drugs studied
Stephen Salloway, MDButler Hospital2 years of reported clinical research
Studies Alzheimer's Disease
Studies Mild Cognitive Impairment
4 reported clinical trials
6 drugs studied
Clinical Trials running at Butler Hospital
Depression
Alzheimer's Disease
Alcoholism
Suicide Attempt
Suicide
Major Depressive Disorder
Suicidal Thoughts
Suicide and Self-Harm
Mild Cognitive Impairment
Opioid Use Disorder
Maintenance TMS
for Depression
The goal of this study is to evaluate the use of ecological-momentary-assessment (EMA) as a method for scheduling maintenance treatments for patients with Major Depressive Disorder (MDD) who responded to an initial acute course of Transcranial Magnetic Stimulation (TMS). To assess symptom re-emergence and severity over time, the Patient Health Questionnaire-9 item (PHQ-9) will be administered weekly via a prompt with a link send to a participants' smart phones. Adaptive algorithm software will monitor each participant's PHQ-9 scores over time and determine when a threshold increase in symptoms has occured and maintenance TMS sessions should be offered. Participants in this study will be randomized to either receive weekly EMA (monitoring only) or weekly EMA with maintenance TMS sessions (scheduled as indicated by the EMA algorithm). Participation for each subject will last for one year, with maintenance TMS offered as an adjunct to ongoing treatment as usual (TAU) for depression, i.e., ongoing pharmacotherapy, psychotherapy.
Recruiting1 award N/A4 criteria
Exercise + TMS
for Treatment Resistant Depression
Given the growing evidence that aerobic increases cortical excitability and promotes neuroplasticity, the scientific premise for its potential priming effect on the brain is strong. Combining AE with rTMS may produce a neural environment optimized for a robust physiological effect of rTMS, thereby leading to improved depression outcomes. With positive findings, this study would provide preliminary support for an innovative, safe and feasible approach for improving outcomes for this significant public health problem.
Recruiting1 award N/A1 criteria
Mindfulness-Based Therapy
for Depression
The primary objective for this project is to test whether affective executive functioning is a mechanism of action of mindfulness-based cognitive therapy and Wellness for Wellbeing. The main questions it aims to answer are: 1. Test the effect of MBCT vs. Wellness for Wellbeing on affective inhibition (i.e., emotionally valenced inhibition as measured via the affective Go/No Go task) using an RCT. 2. Test the effect of MBCT vs. Wellness for Wellbeing on (a) affective updating and (b) affective shifting. Outcomes will be measured with the affective n-Back and the affective Internal Switching Task, respectively. 3a) The investigators will examine whether depression symptom severity co-varies with change in affective executive functioning (i.e., affecting inhibition, shifting, and updating) over time. 3b) The investigators will examine whether compliance with treatment protocol (e.g., number of classes attended, amount of home practice) predicts endpoint executive functioning. Participants will complete surveys, interviews, and computer tasks, and will be randomized to either Mindfulness-Based Cognitive Therapy or Wellness for Wellbeing.
Recruiting1 award N/A
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Frequently asked questions
What kind of research happens at Butler Hospital?
Butler Hospital is a medical facility located in Providence, Rhode Island. This center is recognized for care of Alzheimer's Disease, Depression, Major Depressive Disorder, Suicide, Dementia and other specialties. Butler Hospital is involved with conducting 155 clinical trials across 86 conditions. There are 10 research doctors associated with this hospital, such as Edward Huey, MD, Meghan Riddle, MD, Brandon Gaudiano, PhD, and Stephen Salloway, MD.