Behavioural Intervention
Movement-2-Music Exercise Program for Mobility Disabilities
This trial is testing the effects of an innovative exercise program, movement-2-music (M2M), on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants will be recruited and randomly enrolled into one of two groups: M2M or waitlist control. The primary aim of this study is to determine the effects of the 12-week M2M program on health and fitness in participants with physical/mobility disabilities. The study will also compare the observed effects of the program to a previous M2M study, and test whether adherence (attendance to the 12-week program) affects the
Neural Bypass System
Neural Bypass System for Quadriplegia
This trial tests a new device called the Bidirectional Neural Bypass System, which aims to help people with severe paralysis move and feel their hands and wrists again. The device works by reading brain signals for movement and sending touch signals back to the brain. It targets individuals with tetraplegia who cannot move or feel their limbs due to spinal cord injuries.
Behavioural Intervention
Combined Hypoxia Therapy and Rehabilitation for Spinal Cord Injury
This trial will investigate whether combining daily hypoxia therapy with massed practice training can improve upper-body function in people with chronic incomplete cervical spinal cord injuries.
Behavioural Intervention
Intermittent Hypoxia + Upper Limb Training for Spinal Cord Injury
This trial will investigate the effect of Acute Intermittent Hypoxia (AIH), in combination with upper extremity training, over the course of a month, to evaluate changes in upper extremity function, dexterity, and ability to complete activities of daily living in individuals with chronic incomplete spinal cord injuries.
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Trials for CSCI Patients
Procedure
Epidural Stimulation for Spinal Cord Injury
This trial uses electrical stimulation of the lower spinal cord to help people with severe spinal cord injuries who can't move their legs or stand. The electrical signals aim to reactivate nerves, improving movement and other bodily functions. Electrical stimulation of the spinal cord has been used for pain relief, spasticity control, and movement restoration in spinal cord injury patients.
Behavioral Intervention
Occupational Therapy for Spinal Cord Compression
This trial aims to understand how rehabilitation therapy can improve brain plasticity and neurological function in patients with spinal cord compression. The study will compare patients who receive rehabilitation after spine surgery with those who do not,
Stem Cell Therapy
Stem Cell Therapy + Exoskeleton/Virtual Reality for Spinal Cord Injury
This trial is investigating whether autologous bone marrow derived stem cells can help improve motor or sensory function in people with spinal cord injury. The treatment involves injections of the cells around the area of the injury, as well as an intravenous injection and intranasal placement. Patients may also be assigned to use exoskeletal movement or virtual reality visualization to help improve function.
Deep Brain Stimulation
DBS for Chronic Pain
This trial is testing a new way to provide deep brain stimulation (DBS) for people with chronic pain that has not been relieved by other treatments. DBS involves surgically placing a small device in the brain that sends electrical signals to specific areas. The goal of this trial is to find out whether DBS is more effective when it is turned on only when needed, rather than continuously.
Neurostimulation Device
Epidural Spinal Cord Stimulation for Spinal Cord Injury
This trial will test a way to improve epidural spinal cord stimulation for people with spinal cord injuries. The study will also look at how well autonomic function (such as blood pressure control) and other functions improve.
Trials for Quadriplegia Patients
Neuroprosthetic Device
Neuroprosthetic System for Spinal Cord Injury
This trial is to test a new, fully implanted device that could help people with cervical spinal cord injuries regain hand function, reach, and trunk function. It is funded by the FDA, NIH, and NINDS.
Behavioural Intervention
Rehabilitation after Surgery for Spinal Cord Injury
This trial is testing if using robots for intense physical therapy can help tetraplegic patients regain hand and arm function after nerve transfer surgery. The therapy aims to retrain the brain to use new nerve connections effectively. Robot-assisted therapy has shown promise in improving upper limb function in patients with neurological impairments, including those with chronic stroke.
Behavioural Intervention
Neurosleeve for Arm Weakness/Paralysis
This trial is testing the NuroSleeve, a wearable device that helps people with weak or paralyzed arms move them using electrical signals. It is aimed at those who haven't fully recovered with standard therapies. The device detects small muscle movements and uses them to activate the brace and stimulate muscles, helping with arm movement. Electrical stimulation has been explored in various contexts, including improving arm and hand function in individuals with spinal cord injuries and post-stroke patients.
Trials With No Placebo
Procedure
Epidural Stimulation for Spinal Cord Injury
This trial uses electrical stimulation of the lower spinal cord to help people with severe spinal cord injuries who can't move their legs or stand. The electrical signals aim to reactivate nerves, improving movement and other bodily functions. Electrical stimulation of the spinal cord has been used for pain relief, spasticity control, and movement restoration in spinal cord injury patients.
Behavioral Intervention
Occupational Therapy for Spinal Cord Compression
This trial aims to understand how rehabilitation therapy can improve brain plasticity and neurological function in patients with spinal cord compression. The study will compare patients who receive rehabilitation after spine surgery with those who do not,
Stem Cell Therapy
Stem Cell Therapy + Exoskeleton/Virtual Reality for Spinal Cord Injury
This trial is investigating whether autologous bone marrow derived stem cells can help improve motor or sensory function in people with spinal cord injury. The treatment involves injections of the cells around the area of the injury, as well as an intravenous injection and intranasal placement. Patients may also be assigned to use exoskeletal movement or virtual reality visualization to help improve function.
Deep Brain Stimulation
DBS for Chronic Pain
This trial is testing a new way to provide deep brain stimulation (DBS) for people with chronic pain that has not been relieved by other treatments. DBS involves surgically placing a small device in the brain that sends electrical signals to specific areas. The goal of this trial is to find out whether DBS is more effective when it is turned on only when needed, rather than continuously.
Neurostimulation Device
Epidural Spinal Cord Stimulation for Spinal Cord Injury
This trial will test a way to improve epidural spinal cord stimulation for people with spinal cord injuries. The study will also look at how well autonomic function (such as blood pressure control) and other functions improve.
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Frequently Asked Questions
Introduction to spinal cord injury
What are the top hospitals conducting spinal cord injury research?
In the realm of groundbreaking clinical trials for spinal cord injury, several hospitals are leading the charge. In the vibrant city of Chicago, Shirley Ryan AbilityLab stands out with its seven active trials dedicated to this complex condition. Over their history, they have conducted a total of 26 spinal cord injury trials since embarking on their pioneering research journey in 2013. Moving south to Louisville, Kentucky, Frazier Rehabilitation and Neuroscience Institute is making significant strides as well. With four ongoing studies focused on spinal cord injuries and a cumulative count of six previous trials dating back to 2011 when they first ventured into this field.
Further down the East Coast lies Charleston's Medical University of South carolina (MUSC), where three current clinical trials are underway for individuals with spinal cord injuries. Although relatively new in this area compared to others on our list - having commenced their inaugural trial just recently in2021- MUSC has already established themselves as a reputable center contributing towards cutting-edge advancements.
Heading further south to Miami, the University of Miami is actively involved in three ongoing clinical trials aimed at better understanding and treating spinal cord injuries. Since initiating their first trial in 2002, they have made notable progress by successfully completing 17 additional investigations over time.
Lastly but not least important,Kessler Institute for Rehabilitation located West Orange makes valuable contributions with its three currently active clinical tests devoted solely towards exploring potential treatments for those affected by spinal cord injuries; Kessler holds an impressive forty years long record accounting twenty-four previously held experiments that led them commencing extensive exploration from early days since year2003
These remarkable hospitals signify beacons of hope within the realm of spinal cord injury research and treatment options worldwide.Progress made through these institutions' relentless dedication helps pave unprecedented paths forward toward understandingand unlocking mysteries surroundingspinalcordinjuries.And while there is still much work ahead,the efforts undertakenby these top-tier medical centers ensure improved qualitysoflife for countlessindividualsaffected by spinal cord injury.
Which are the best cities for spinal cord injury clinical trials?
When it comes to spinal cord injury clinical trials, several cities have emerged as key hubs for research and innovation. Louisville, Kentucky leads the pack with 10 active trials focusing on interventions like Spinal Cord Transcutaneous Stimulation and Respiratory Training (scTS+RT) group, Standing, Stepping and Voluntary Movement with spinal cord Epidural Stimulation, and Epidural stimulation + Bladder Capacity Training. Following closely behind is Chicago, Illinois with 9 ongoing studies investigating approaches such as Enhanced Medical Rehabilitation (EMR), rAIH + training by research staff, and Slip Training. Vancouver, British Columbia also plays a significant role in this field with 6 active trials exploring strategies such as TESCoN device - Thoracic stimulation and Activity-Based Therapy. Other notable cities include West Orange in New jersey with 6 active trials emphasizing participants with chronic SCI and Miami in Florida where various studies encompass topics like Nutrition Education Group and Functional Electrical Stimulation Leg Cycle Ergometry. These cities serve as important epicenters for advancing breakthroughs in spinal cord injury treatment through clinical research endeavors.
Which are the top treatments for spinal cord injury being explored in clinical trials?
Exciting advancements are underway in the realm of spinal cord injury treatments, with clinical trials exploring innovative approaches. One promising option is Enhanced Medical Rehabilitation (EMR), which is currently being tested in two active trials and has a total of two all-time trials dedicated to spinal cord injury since its introduction in 2022. Another intriguing avenue is Operant Conditioning of Cutaneous Reflexes, with one ongoing trial and one all-time trial specifically targeting spinal cord injury since its initial listing in 2023. These cutting-edge therapies hold great potential for improving the lives of individuals affected by spinal cord injuries, offering hope for restored function and increased mobility.
What are the most recent clinical trials for spinal cord injury?
Promising advancements are being made in the field of spinal cord injury research, bringing hope to those affected by this devastating condition. One notable clinical trial focuses on investigating the potential benefits of Istradefylline and NVG-291 for spinal cord injury patients. These drugs are currently undergoing Phase 1 and Phase 2 trials, with results expected to shed light on their effectiveness in improving outcomes for individuals with spinal cord injuries. Additionally, remote CMR has emerged as a novel approach worth exploring further through its Phase 2 trial to enhance diagnosis and monitoring capabilities remotely. Furthermore, an ongoing study is examining the impact of UA supplementation and exercise within paraplegia groups as a means to improve quality of life for individuals living with spinal cord injuries. With these cutting-edge trials underway, there is renewed optimism that innovative interventions may soon transform the lives of those impacted by spinal cord injuries.
What spinal cord injury clinical trials were recently completed?
Two recent clinical trials have made strides in the field of spinal cord injury research. In February 2019, Spaulding Rehabilitation Hospital concluded a trial examining the potential benefits of Oxycodone for patients with spinal cord injuries. Similarly, in December 2017, Allan Dietz, Ph.D., completed a trial investigating the use of Autologous, Adipose derived Mesenchymal Stem Cells to potentially improve outcomes for individuals with spinal cord injuries. These important studies contribute to our understanding and offer hope for advancements in treatment options for those affected by spinal cord injuries.