NMDA Receptor Antagonist
Ketamine for Bipolar Depression
Recruiting1 awardPhase 2
Cleveland, Ohio
"This trial is observing patients with bipolar depression who haven't responded to treatment, and they are being given ketamine intravenously. The study also includes using fMRI to understand the effects of ketamine
Behavioural Intervention
IPSRT + Healthy Lifestyle Intervention for Bipolar Disorder Risk
Recruiting1 award4 criteria
Pittsburgh, Pennsylvania
This trial tests a telehealth therapy called IPSRT to help children at high risk of bipolar disorder due to having a bipolar parent. The therapy focuses on improving sleep and daily routines to prevent the disorder. The study will monitor outcomes over time. Interpersonal and Social Rhythm Therapy (IPSRT) was specifically developed to manage stressful life events, improve disruptions in social and circadian rhythms, and has shown efficacy in treating bipolar disorder.
Brain Stimulation
Theta Burst Stimulation for Bipolar Disorder
Recruiting1 award13 criteria
Pittsburgh, Pennsylvania
This trial will study the effects of transcranial brain stimulation on brain activity and emotions in adults with and without bipolar disorder, in order to better understand the predisposing brain mechanisms of bipolar disorder.
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Trials for BD Patients
Behavioural Intervention
Smoking Cessation App for Mental Health Disorders
Recruiting1 award
Durham, North Carolina
This trial will test a new smartphone app called Quit on the Go, designed to help people with serious mental illness quit smoking. The study will compare this app to traditional methods, with both groups also using nicotine patches and gum. The goal is to see if the app helps more people quit smoking and if it is cost-effective.
Ketamine for Bipolar Disorder
Recruiting1 awardPhase 2
Toronto, Ontario
This trial will study the effects of four doses of ketamine on people with treatment-resistant bipolar disorder, to see if it is an effective, safe and tolerable treatment. The primary outcome will be change in Montgomery-Ã…sberg Depression Rating Scale (MADRS) scores from baseline to day 14.
Cannabinoid
Medical Cannabis for Chronic Pain
Recruiting1 awardPhase 2
Boca Raton, Florida
This trial will investigate if medical cannabis can effectively reduce pain and improve quality of life for patients with chronic conditions. The study will gather data through an online questionnaire about patients' use of cannabis and its effects. Medical cannabis interacts with the body's natural system to help manage pain and other symptoms. Medical cannabis has been increasingly studied and used as an alternative treatment for managing chronic pain, with numerous studies supporting its potential benefits.
Behavioral Intervention
Future Thinking Intervention for Smoking and Bipolar Disorder
Recruiting1 award1 criteria
Boston, Massachusetts
This trial involves a 6-session online program called Future Self-BD that helps people imagine positive future events that can be improved by quitting smoking. The sessions will be held on a secure video platform and
Trials for Schizoaffective Disorder Patients
Behavioural Intervention
Smoking Cessation App for Mental Health Disorders
Recruiting1 award
Durham, North Carolina
This trial will test a new smartphone app called Quit on the Go, designed to help people with serious mental illness quit smoking. The study will compare this app to traditional methods, with both groups also using nicotine patches and gum. The goal is to see if the app helps more people quit smoking and if it is cost-effective.
Behavioural Intervention
Dexmedetomidine vs Lorazepam for Agitation in Schizophrenia or Bipolar Disorder
Recruiting3 awardsPhase 4
Philadelphia, Pennsylvania
This trial compares the effects of a drug (dexmedetomidine) to a known drug (lorazepam) in treating agitation in people with schizophrenia or bipolar disorder.
Alpha-2 Adrenergic Receptor Agonist
Dexmedetomidine for Agitation in Schizophrenia and Bipolar Disorder
Recruiting1 awardPhase 3
Las Vegas, Nevada
This trial tests an investigational medication for treating episodes of agitation in bipolar I/II, schizophrenia, schizoaffective and schizophreniform disorder. It compares the drug to a placebo.
Atypical Antipsychotic
Lumateperone for Schizophrenia and Bipolar Disorder
Recruiting2 awardsPhase 3
Anaheim, California
This trial is being conducted at multiple locations worldwide and will last for 26 weeks. It aims to evaluate the safety and tolerability of lumateperone in children with schizophrenia or bipolar disorder.
Behavioural Intervention
Ketogenic Diet for Bipolar Disorder
Recruiting1 award
Belmont, Massachusetts
This trial is studying the effects of the ketogenic diet, along with standard treatment, on brain energy and mental health symptoms in people with bipolar disorder and schizoaffective disorder who are experiencing their first episode
Phase 3 Trials
Alpha-2 Adrenergic Receptor Agonist
Dexmedetomidine for Agitation in Schizophrenia and Bipolar Disorder
Recruiting1 awardPhase 3
Las Vegas, Nevada
This trial tests an investigational medication for treating episodes of agitation in bipolar I/II, schizophrenia, schizoaffective and schizophreniform disorder. It compares the drug to a placebo.
Atypical Antipsychotic
Lumateperone for Schizophrenia and Bipolar Disorder
Recruiting2 awardsPhase 3
Anaheim, California
This trial is being conducted at multiple locations worldwide and will last for 26 weeks. It aims to evaluate the safety and tolerability of lumateperone in children with schizophrenia or bipolar disorder.
Probiotics for Bipolar Disorder
Recruiting1 awardPhase 3
Dallas, Texas
This trial tests if taking capsules with good bacteria can help people who were hospitalized for severe mood episodes avoid being hospitalized again. The capsules aim to improve gut health, which might reduce body inflammation and help with mental health. The study will also look at changes in mood, psychiatric symptoms, and cognitive abilities.
Atypical Antipsychotic
Cariprazine for Pediatric Schizophrenia
Recruiting2 awardsPhase 3
Dothan, Alabama
This trial is testing the safety and effectiveness of cariprazine in children and teens with schizophrenia, bipolar I disorder, or autism. The goal is to see if the medication is safe and beneficial for use in these young patients.
Atypical Antipsychotic
OLZ/SAM for Schizophrenia
Recruiting2 awardsPhase 3
Cincinnati, Ohio
This trial evaluates the safety and tolerability of OLZ/SAM in children and adolescents with schizophrenia or Bipolar I disorder. OLZ/SAM combines olanzapine to manage symptoms and samidorphan to reduce weight gain. Olanzapine is a well-established antipsychotic effective for schizophrenia and bipolar I disorder, but its use is limited by significant weight gain; samidorphan is added to mitigate this side effect.
Trials With No Placebo
Behavioural Intervention
(Online Study) Healthy Lifestyles for Bipolar Disorder
Recruiting1 award4 criteria
Berkeley, California
This trial aims to compare the effects of two different healthy lifestyles on people with bipolar disorder. The trial will investigate the acceptability of time-restricted eating and the Mediterranean diet for those who are already taking
Behavioural Intervention
Smoking Cessation App for Mental Health Disorders
Recruiting1 award
Durham, North Carolina
This trial will test a new smartphone app called Quit on the Go, designed to help people with serious mental illness quit smoking. The study will compare this app to traditional methods, with both groups also using nicotine patches and gum. The goal is to see if the app helps more people quit smoking and if it is cost-effective.
Ketamine for Bipolar Disorder
Recruiting1 awardPhase 2
Toronto, Ontario
This trial will study the effects of four doses of ketamine on people with treatment-resistant bipolar disorder, to see if it is an effective, safe and tolerable treatment. The primary outcome will be change in Montgomery-Ã…sberg Depression Rating Scale (MADRS) scores from baseline to day 14.
NMDA receptor antagonist
IM Ketamine vs Midazolam for Suicidal Thoughts
Recruiting3 awardsPhase 4
New York, New York
This trial tests whether a shot of ketamine can quickly reduce suicidal thoughts in depressed adults who visit the emergency room. These patients are at high risk of suicide and need fast-acting treatment. Ketamine works by quickly changing brain chemicals to improve mood and reduce suicidal thoughts. It has been found to rapidly reduce depressive symptoms and suicidal thoughts, making it a potential fast-acting treatment for suicidality.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.