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Florida State University
Claim this profileTallahassee, Florida 32301
Global Leader in Obesity
Conducts research for Anxiety Disorders
Conducts research for Suicide
Conducts research for Depression
Conducts research for High Blood Pressure
75 reported clinical trials
5 medical researchers
Summary
Florida State University is a medical facility located in Tallahassee, Florida. This center is recognized for care of Obesity, Anxiety Disorders, Suicide, Depression, High Blood Pressure and other specialties. Florida State University is involved with conducting 75 clinical trials across 88 conditions. There are 5 research doctors associated with this hospital, such as Justin Riddle, PhD, Alexandria Meyer, PhD, Michael J Ormsbee, PhD, and Walter Boot, PhD.Top PIs
Justin Riddle, PhDFlorida State University1 year of reported clinical research
Studies Depression
Studies Anhedonia
2 reported clinical trials
6 drugs studied
Alexandria Meyer, PhDFlorida State University4 years of reported clinical research
Studies Anxiety
Studies Anxiety Disorders
1 reported clinical trial
1 drug studied
Michael J Ormsbee, PhDFlorida State University2 years of reported clinical research
Studies Postmenopausal Syndrome
Studies Prediabetes
1 reported clinical trial
2 drugs studied
Walter Boot, PhDFlorida State University1 year of reported clinical research
Studies Mild Cognitive Impairment
Studies Cognitive Impairment
1 reported clinical trial
3 drugs studied
Clinical Trials running at Florida State University
Obesity
Depression
Osteoarthritis
Attention Deficit Hyperactivity Disorder (ADHD)
Major Depressive Disorder
Postmenopausal Syndrome
Prediabetes
Healthy Subjects
Marital Relationships
Asthma
Exercise Training
for Fat Metabolism in Postmenopausal Women
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.
Recruiting1 award N/A1 criteria
Exercise
for Obesity
Impaired endothelial function is observed in disease states related to obesity, such as atherosclerosis, coronary artery disease, and diabetes. Reactive oxygen species (ROS) production and resultant oxidative stress contribute to the development of these obesity-related diseases. The enzyme NADPH-oxidase is a major source of oxidative stress within the vasculature, and has been linked with the Metabolic Syndrome. In the investigator's previously funded studies, the investigators demonstrated for the first time that: 1) in vivo ROS were elevated in skeletal muscle of obese as compared to lean or overweight human subjects, 2) perfusion of the NADPH-oxidase inhibitor apocynin locally into muscle normalized ROS levels and reversed local microvascular endothelial dysfunction in the obese individuals, and 3) aerobic exercise training was effective at attenuating in vivo hydrogen peroxide production and reversing microvascular endothelial dysfunction in the obese individuals. The investigators will investigate in this R15 renewal application the mechanism of exercise training-induced alterations in ROS production and action on endothelial dysfunction in obesity using our newly developed microdialysis methodology of monitoring ROS production, in combination with analysis of muscle biopsy samples obtained before and after our previously tested 8-week intervention of aerobic interval exercise training. The objectives of this study are to determine the impact of in vivo NADPH oxidase activity on endothelial function in obese individuals, and to determine the mechanism of training-induced improvements in endothelial function. The investigator's unique microdialysis methodology will allow monitoring of microvascular/endothelial function and ROS generation, as well as the administration of pharmacological agents directly into muscle. The central hypothesis is that it is upregulation of both mitochondrial ROS and NADPH oxidase-derived ROS that results in endothelial dysfunction in obesity, and that exercise training down-regulates mitochondrial-derived ROS, and NADPH oxidase 4, thereby improving endothelial function. The aims of this proposal are to: 1) determine the contributions of mitochondrial ROS and specific NADPH oxidase isoforms to the NADPH oxidase dependent endothelial dysfunction in skeletal muscle of obese individuals; 2) determine the mechanism of ROS reduction and improved endothelial function resulting from an 8-week aerobic interval training program.
Recruiting1 award N/A
Inspiratory Muscle Training
for Obesity
The purpose of this study is to determine whether inspiratory muscle strength training reduces blood pressure in adults with obesity.
Recruiting0 awards N/A1 criteria
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Frequently asked questions
What kind of research happens at Florida State University?
Florida State University is a medical facility located in Tallahassee, Florida. This center is recognized for care of Obesity, Anxiety Disorders, Suicide, Depression, High Blood Pressure and other specialties. Florida State University is involved with conducting 75 clinical trials across 88 conditions. There are 5 research doctors associated with this hospital, such as Justin Riddle, PhD, Alexandria Meyer, PhD, Michael J Ormsbee, PhD, and Walter Boot, PhD.