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Norton Children's Hospital
Claim this profileLouisville, Kentucky 40202
Global Leader in Leukemia
Global Leader in Tumors
Conducts research for Brain Tumor
Conducts research for Lymphoblastic Leukemia-Lymphoma
Conducts research for Sarcoma
281 reported clinical trials
16 medical researchers
Summary
Norton Children's Hospital is a medical facility located in Louisville, Kentucky. This center is recognized for care of Leukemia, Tumors, Brain Tumor, Lymphoblastic Leukemia-Lymphoma, Sarcoma and other specialties. Norton Children's Hospital is involved with conducting 281 clinical trials across 483 conditions. There are 16 research doctors associated with this hospital, such as William T. Tse, Edward J. Kim, John Berkenbosch, MD, and Kerry K. McGowan.Area of expertise
1Leukemia
Global LeaderStage II
NTRK1 positive
NTRK positive
2Tumors
Global LeaderStage IV
Stage I
Stage II
Top PIs
William T. TseMetroHealth Medical Center5 years of reported clinical research
Expert in Cancer
Studies Lung Cancer
49 reported clinical trials
117 drugs studied
Edward J. KimUniversity of California Davis Comprehensive Cancer Center1 year of reported clinical research
Studies Adenocarcinoma
Studies Cancer
30 reported clinical trials
68 drugs studied
John Berkenbosch, MDNorton Children's Hospital: University of Louisville3 years of reported clinical research
Studies Critical Illness
Studies Pressure Sore
4 reported clinical trials
3 drugs studied
Kerry K. McGowanUniversity of Louisville, Norton Children's Hospital7 years of reported clinical research
Studies Langerhans Cell Histiocytosis
Studies Histiocytosis
3 reported clinical trials
19 drugs studied
Clinical Trials running at Norton Children's Hospital
Brain Tumor
Germ Cell Tumors
Osteosarcoma
Rhabdomyosarcoma
Langerhans Cell Histiocytosis
Non-Hodgkin's Lymphoma
Astrocytoma
Acute Lymphoblastic Leukemia
Tumors
Lymphoma
Selumetinib vs. Chemotherapy
for Brain Cancer
This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
Selumetinib vs Carboplatin/Vincristine
for Brain Cancer
This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the optic pathway (vision nerves). Selumetinib is a drug that works by blocking some enzymes that low-grade glioma tumor cells need for their growth. This results in killing tumor cells. Drugs used as chemotherapy, such as carboplatin and vincristine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether selumetinib works better in treating patients with NF1-associated low-grade glioma compared to standard therapy with carboplatin and vincristine.
Recruiting2 awards Phase 328 criteria
Selumetinib + Vinblastine
for Low-Grade Glioma
This phase III trial investigates the best dose of vinblastine in combination with selumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinib alone in treating children and young adults with low-grade glioma (a common type of brain cancer) that has come back after prior treatment (recurrent) or does not respond to therapy (progressive). Selumetinib is a drug that works by blocking a protein that lets tumor cells grow without stopping. Vinblastine blocks cell growth by stopping cell division and may kill cancer cells. Giving selumetinib in combination with vinblastine may work better than selumetinib alone in treating recurrent or progressive low-grade glioma.
Recruiting2 awards Phase 339 criteria
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Frequently asked questions
What kind of research happens at Norton Children's Hospital?
Norton Children's Hospital is a medical facility located in Louisville, Kentucky. This center is recognized for care of Leukemia, Tumors, Brain Tumor, Lymphoblastic Leukemia-Lymphoma, Sarcoma and other specialties. Norton Children's Hospital is involved with conducting 281 clinical trials across 483 conditions. There are 16 research doctors associated with this hospital, such as William T. Tse, Edward J. Kim, John Berkenbosch, MD, and Kerry K. McGowan.