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VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Claim this profileJamaica Plain, Massachusetts 02130
Global Leader in Post-Traumatic Stress Disorder
Global Leader in Lung Cancer
Conducts research for Traumatic Stress Disorders
Conducts research for Chronic Obstructive Pulmonary Disease
Conducts research for Traumatic Brain Injury
269 reported clinical trials
28 medical researchers
Summary
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA is a medical facility located in Jamaica Plain, Massachusetts. This center is recognized for care of Post-Traumatic Stress Disorder, Lung Cancer, Traumatic Stress Disorders, Chronic Obstructive Pulmonary Disease, Traumatic Brain Injury and other specialties. VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA is involved with conducting 269 clinical trials across 283 conditions. There are 28 research doctors associated with this hospital, such as Marilyn L Moy, MD, David William Sparrow, DSc, Gyorgy Baffy, MD, and Jason L. Vassy, MD, MPH, SM.Top PIs
Marilyn L Moy, MDVA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA2 years of reported clinical research
Studies Chronic Obstructive Pulmonary Disease
Studies Chronic Musculoskeletal Pain
5 reported clinical trials
5 drugs studied
David William Sparrow, DScVA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA5 years of reported clinical research
Studies Parkinson's Disease
Studies Dysarthria
4 reported clinical trials
8 drugs studied
Gyorgy Baffy, MDVA Boston5 years of reported clinical research
Studies Liver Disease
Studies Fibrosis
2 reported clinical trials
2 drugs studied
Jason L. Vassy, MD, MPH, SMVA Boston Healthcare System4 years of reported clinical research
Studies Prostate Cancer
Studies Colorectal Cancer
2 reported clinical trials
2 drugs studied
Clinical Trials running at VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Post-Traumatic Stress Disorder
Prostate Cancer
Depression
Chronic Obstructive Pulmonary Disease
Traumatic Brain Injury
Parkinson's Disease
Chronic Pain
Bladder Cancer
Opioid Use Disorder
Traumatic Stress Disorders
Sertraline
for PTSD
This is a research study to examine the effectiveness of a brief screening method that may predict which people with posttraumatic stress disorder (PTSD) or depression are most likely to show a positive response to selective serotonin reuptake inhibitor (SSRI) medications. Participants will be recruited over approximately 5.25 years, until at least 94 participants complete the 17 week study.
Recruiting2 awards Phase 44 criteria
Family Involvement
for PTSD
Although effective treatments for PTSD exist, high rates of treatment dropout and sub-optimal response rates remain common. Incorporating family members in treatment represents one avenue for improving outcomes and providing Veteran-centered care, and surveys of Veterans in outpatient VA PTSD care indicate that 80% desire family involvement. The VA has invested many years and millions of dollars on the dissemination of Cognitive Processing Therapy (CPT) and Prolonged Exposure (PE) for PTSD. A family-based intervention that complements these two first-line treatments would capitalize on existing treatment infrastructure while also potentially boosting outcomes and retention. Preliminary testing of the proposed Brief Family Intervention (BFI) resulted in 50% less dropout from CPT/PE among Veterans whose family members received the BFI. There was also a large impact on PTSD symptoms at 16 weeks (d = 1.12) in favor of the BFI group. The goal of this study is to test the effectiveness of the BFI among a fully-powered sample. One hundred Veteran-family member dyads (n = 200) will be recruited. Veterans will be beginning a course of usual-care CPT or PE at one of two VA sites. Family members will be randomized to receive or not receive the BFI, a two-session psychoeducational and skills-based protocol. PTSD symptom severity and treatment retention will be the primary outcomes. Assessments will be conducted by independent evaluators at baseline, 6-, 12-, 18-, and 26-weeks. Veterans whose family members receive the BFI are expected to have lower dropout and a greater rate of change in their PTSD symptoms compared to Veterans whose family members do not receive the BFI. If the BFI is found to increase the effectiveness of and retention in CPT/PE, it will be a highly appealing option for incorporating families into Veterans' PTSD care.
Recruiting1 award N/A9 criteria
Cognitive Processing Therapy
for PTSD
Recent estimates suggest that over 610,000 US Veterans treated by the Veterans Health Administration (VHA) suffer from PTSD, a disorder that can be chronic and debilitating. The heterogeneity of the 20 symptoms of PTSD; comorbidity with disorders such as depression, panic, and substance use; high rates of lingering effects of physical injury; and suicidality all contribute to complex clinical presentations and can exact a significant toll on functioning, quality of life, and well-being even decades after exposure to the traumatic event. Perhaps spurred by the President's New Freedom Commission on Mental Health, psychosocial rehabilitation has shifted from the periphery in mental health recovery models to a more primary focus in clinical settings, including recommendations for use of psychosocial rehabilitation techniques in trauma-focused mental health care. Support for the efficacy of psychosocial rehabilitation techniques in PTSD recovery programs has burgeoned in recent years and data supporting psychological treatments for PTSD has increased exponentially, yet the two approaches to recovery have largely remained independent. Cognitive Processing Therapy (CPT), the evidence-based psychotherapy (EBP) for PTSD most frequently delivered within VHA, yields large magnitude reductions in primary PTSD outcomes. Corresponding gains in occupational, social, leisure, and sexual functioning, and in health-related concerns have also been demonstrated. Despite CPT's effectiveness, there is room for improvement in overall outcomes and patient engagement. Further, improvements in functioning and quality of life are more modest than those observed in PTSD and associated mental health symptoms. Prior work suggests that unaddressed difficulties in functioning contribute to premature dropout from EBPs for PTSD among Veterans. Directly targeting impairments associated with psychosocial functioning has the potential to substantially increase the scope of recovery beyond the core symptoms of PTSD and facilitate greater patient engagement, resulting in more Veterans benefitting from CPT. Modifying the CPT protocol to personalize the intervention for the individual patient has resulted in better overall response rates for a wider variety of patient populations suffering from complicated clinical presentations. Case formulation (CF) is a well-established approach to cognitive-behavioral treatment that facilitates a collaborative process between providers and patients to guide the tailoring of treatment to meet idiosyncratic patient needs. Integrating CF strategies into the existing CPT protocol will enable providers to personalize CPT to directly address impairment in functioning as well as provide the latitude to directly intervene with the complex challenges that threaten optimal outcomes within the context of trauma-focused therapy. CF-integrated CPT (CF-CPT) expands and enhances the CPT protocol to facilitate a personalized and flexible approach to treating PTSD that prioritizes the administration of the full dose of CPT while expanding the protocol to directly target important domains of functioning and result in more holistic outcomes. This controlled treatment outcome trial will randomize a national sample of CPT providers (Veteran n = 200; provider n = 50) to either deliver CF-CPT or CPT to compare the relative effectiveness of CF-CPT to CPT in improving primary outcomes, including Veterans' psychosocial functioning, quality of life and well-being over the course of treatment and 3-month follow-up as compared to Veterans who receive standard CPT. Further, Veterans who receive CF-CPT will demonstrate greater reductions in PTSD and depression over the course of treatment and 3-month follow-up than those who receive CPT. This study also seeks to determine the effectiveness of CF-CPT as compared to CPT in improving Veterans' treatment engagement (CF-CPT will demonstrate higher rates of Veteran treatment completion than CPT). This study will valuate CF-CPT's indirect impact on Veterans' psychosocial functioning and PTSD/depression symptomology Change in functioning, quality of life, and well-being \& PTSD and depression will be associated with improvement in the idiosyncratic clinical challenges targeted by the CF. This study will also examine between-group differences across secondary outcomes (e.g. anger, anxiety, health concerns, sleep, numbing/reactivity) and describe the frequency and type of the clinical and rehabilitative needs of the Veterans and the type and duration of divergences (e.g. rehabilitative techniques) made by providers.
Recruiting1 award N/A1 criteria
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Frequently asked questions
What kind of research happens at VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA?
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA is a medical facility located in Jamaica Plain, Massachusetts. This center is recognized for care of Post-Traumatic Stress Disorder, Lung Cancer, Traumatic Stress Disorders, Chronic Obstructive Pulmonary Disease, Traumatic Brain Injury and other specialties. VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA is involved with conducting 269 clinical trials across 283 conditions. There are 28 research doctors associated with this hospital, such as Marilyn L Moy, MD, David William Sparrow, DSc, Gyorgy Baffy, MD, and Jason L. Vassy, MD, MPH, SM.