Dr. Adam M Sonabend, MD
Claim this profileNorthwestern University
Studies Glioblastoma
Studies Gliomas
2 reported clinical trials
4 drugs studied
Affiliated Hospitals
Clinical Trials Adam M Sonabend, MD is currently running
Ultrasound-assisted Chemotherapy
for Glioblastoma
Paclitaxel is among the most active agents against glioblastoma in preclinical models. However, its clinical use has been hampered by the blood-brain barrier (BBB). In this trial we will implant a novel device with 9 ultrasound emitters allowing to temporarily and reversibly open the BBB immediately prior to chemotherapy infusion with albumin-bound paclitaxel. In the phase 1 component, increasing doses of chemotherapy will be delivered as long deemed safe based on the prior patient not experiencing severe toxicity. Once the the recommended dosing has been established, carboplatin will be added to the regimen and additional patients will be treated in order to better evaluate the antitumor efficacy of this novel treatment. The device will be implanted at the time of surgical resection of the recurrent tumor. During that procedure and when feasible, a first test dose of the chemotherapy will be administered in the operating room after sonication (procedure of activating ultrasound and opening the BBB) and tissue concentrations in different parts of the resected tumor will be measured. In select patients, the sonication procedure may occur immediately after the test dose of chemotherapy is administered. The objectives of this trial are to establish a safe and effective dose of albumin-bound paclitaxel, to demonstrate that the opening of the BBB increases chemotherapy concentration in the tumor, and to estimate how effective this treatment is in reducing the tumor burden and prolonging life.
Recruiting3 awards Phase 1 & 219 criteria
Ultrasound-Assisted Chemotherapy
for Glioblastoma
This trial tests a new method to treat recurrent brain cancer using an ultrasound device called SonoCloud-9. The device helps open the brain's protective barrier so that more of the chemotherapy drug carboplatin can reach the tumor. The goal is to see if this combination makes the treatment more effective. Carboplatin has been used in various studies for treating high-grade gliomas and glioblastomas, often showing modest efficacy due to low tissue concentration when delivered intravenously.
Recruiting2 awards Phase 3
More about Adam M Sonabend, MD
Clinical Trial Related4 years of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Adam M Sonabend, MD has experience with
- Carboplatin
- Paclitaxel
- Sonication For Opening Of Blood-brain Barrier
- SonoCloud-9 (SC9)
Breakdown of trials Adam M Sonabend, MD has run
Glioblastoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Adam M Sonabend, MD specialize in?
Adam M Sonabend, MD focuses on Glioblastoma and Gliomas. In particular, much of their work with Glioblastoma has involved IDH negative patients, or patients who are undergoing treatment.
Is Adam M Sonabend, MD currently recruiting for clinical trials?
Yes, Adam M Sonabend, MD is currently recruiting for 2 clinical trials in Chicago Illinois. If you're interested in participating, you should apply.
Are there any treatments that Adam M Sonabend, MD has studied deeply?
Yes, Adam M Sonabend, MD has studied treatments such as Carboplatin, Paclitaxel, Sonication for opening of blood-brain barrier.
What is the best way to schedule an appointment with Adam M Sonabend, MD?
Apply for one of the trials that Adam M Sonabend, MD is conducting.
What is the office address of Adam M Sonabend, MD?
The office of Adam M Sonabend, MD is located at: Northwestern University, Chicago, Illinois 60611 United States. This is the address for their practice at the Northwestern University.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.