Dr. Alexander Khoruts, MD
Claim this profileUniversity of Minnesota
Studies Pulmonary Arterial Hypertension
Studies Pulmonary Hypertension
2 reported clinical trials
5 drugs studied
Affiliated Hospitals
Clinical Trials Alexander Khoruts, MD is currently running
Microbiota Transplant Therapy
for Pulmonary Hypertension
This pilot clinical trial will evaluate the initial safety, feasibility, and pharmacokinetics of microbiota transplant therapy (MTT) with antibiotic pre-conditioning and fiber supplementation vs. placebo in patients with pulmonary arterial hypertension (PAH). This trial will inform development of future trials of MTT as a treatment for PAH. 24 PAH patients will be randomized to receive either MTT with antibiotic preconditioning + fiber supplementation, MTT with antibiotic preconditioning + placebo supplementation, or placebo + placebo supplementation. MTT will in a capsule form composed of freeze-dried, encapsulated intestinal microbiota from healthy donors. Fiber supplementation will be 10-14 gm oral fiber supplement. Patients will be followed at week 1, week 2, week 4, week 12, and week 24. Patient will undergo stool sample collection at baseline, week 1, week 4, and week 12, blood sample collection at baseline, week 4, and week,12. In addition, patient will undergo an echocardiogram, six-minute walk test (6MWT) and quality of life questionnaire at baseline and at week 12.
Recruiting0 awards Phase 13 criteria
Specialized Diets
for Clostridium Difficile Infection
Recurrent Clostridioides difficle infection (rCDI) is a very significant problem in its own right and current fecal microbiota transplant (FMT) -based therapeutics will benefit from their optimization for this indication. It is likely that appropriate nutritional support coupled with microbiota-based drugs will yield superior clinical outcomes. However, both diet and gut microbiome are very complex. This project, which is based on a wealth of FMT experience, both clinical and investigational, over the past decade along with the novel techniques developed to identify dietary patterns and food groups that explain the most variation in gut microbiome, offers an ideal platform for performing systematic research in nutritional support that promotes gut microbiota health. The purpose is to Generate preliminary data with regards to tolerability of the Microbiota enhancing and nourishing diet (MEND) and its effects on the fecal microbiota in rCDI patients following FMT with the goal of developing larger clinical trials aimed to optimize post-FMT dietary management.
Recruiting1 award N/A
More about Alexander Khoruts, MD
Clinical Trial Related1 year of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Alexander Khoruts, MD has experience with
- MTT With Antibiotic Preconditioning + Fiber Supplementation
- MTT With Antibiotic Preconditioning + Placebo Supplementation
- MTT With Placebo + Placebo Supplementation
- MEND Diet
- MNICE Diet
Breakdown of trials Alexander Khoruts, MD has run
Pulmonary Arterial Hypertension
Pulmonary Hypertension
Clostridium Difficile Infection
Fecal Microbiota Transplant
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Alexander Khoruts, MD specialize in?
Alexander Khoruts, MD focuses on Pulmonary Arterial Hypertension and Pulmonary Hypertension. In particular, much of their work with Pulmonary Arterial Hypertension has involved treating patients, or patients who are undergoing treatment.
Is Alexander Khoruts, MD currently recruiting for clinical trials?
Yes, Alexander Khoruts, MD is currently recruiting for 2 clinical trials in Minneapolis Minnesota. If you're interested in participating, you should apply.
Are there any treatments that Alexander Khoruts, MD has studied deeply?
Yes, Alexander Khoruts, MD has studied treatments such as MTT with antibiotic preconditioning + fiber supplementation, MTT with antibiotic preconditioning + placebo supplementation, MTT with placebo + placebo supplementation.
What is the best way to schedule an appointment with Alexander Khoruts, MD?
Apply for one of the trials that Alexander Khoruts, MD is conducting.
What is the office address of Alexander Khoruts, MD?
The office of Alexander Khoruts, MD is located at: University of Minnesota, Minneapolis, Minnesota 55414 United States. This is the address for their practice at the University of Minnesota.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.