Dr. Marcio H. Malogolowkin, MD ...

Dr. Marcio H. Malogolowkin

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University of California Davis Comprehensive Cancer Center

Expert in Cancer
Expert in Neuroblastoma
40 reported clinical trials
89 drugs studied

About Marcio H. Malogolowkin

Education:

  • Earned an MD from the University of São Paulo School of Medicine, Brazil, in 1986.
  • Completed a Residency in Pediatrics at the University of California, San Francisco (UCSF) in 1990.
  • Finished a Fellowship in Pediatric Hematology/Oncology at UCSF in 1993.
  • Board Certified in Pediatrics and Pediatric Hematology/Oncology by the American Board of Pediatrics.

Experience:

  • Currently serves as the Division Chief of Pediatric Hematology/Oncology at the University of California Davis Comprehensive Cancer Center.
  • Holds a position as a Professor of Pediatrics at the UC Davis School of Medicine.

Area of expertise

1

Cancer

Global Leader

Marcio H. Malogolowkin has run 15 trials for Cancer. Some of their research focus areas include:

Stage I
Stage IV
Stage II
2

Neuroblastoma

Global Leader

Marcio H. Malogolowkin has run 14 trials for Neuroblastoma. Some of their research focus areas include:

Stage IV
MYC positive
MYC negative

Affiliated Hospitals

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University Of California Davis Comprehensive Cancer Center

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University Of California Davis Health System - Comprehensive Cancer Center

Clinical Trials Marcio H. Malogolowkin is currently running

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Inotuzumab Ozogamicin

for Acute Lymphoblastic Leukemia

This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells in a targeted way and delivers calicheamicin to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also study the outcomes of patients with mixed phenotype acute leukemia (MPAL) and disseminated B lymphoblastic lymphoma (B-LLy) when treated with high-risk ALL chemotherapy. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first two phases of therapy: Induction and Consolidation. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-consolidation treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (interim maintenance I, delayed intensification, interim maintenance II, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of delayed intensification. Other aims of this study include investigating whether treating both males and females with the same duration of chemotherapy maintains outcomes for males who have previously been treated for an additional year compared to girls, as well as to evaluate the best ways to help patients adhere to oral chemotherapy regimens. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.

Recruiting

2 awards

Phase 3

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Chemotherapy

for Cancer

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.

Recruiting

2 awards

Phase 3

26 criteria

More about Marcio H. Malogolowkin

Clinical Trial Related

8 years of experience running clinical trials · Led 40 trials as a Principal Investigator · 11 Active Clinical Trials

Treatments Marcio H. Malogolowkin has experience with

  • Cyclophosphamide
  • Etoposide
  • Radiation Therapy
  • Vincristine Sulfate
  • Doxorubicin Hydrochloride
  • Dexamethasone

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