Dr. Samuel Klein, MD
Claim this profileWashington University School of Medicine
Studies Obesity
Studies Diabetes Mellitus
8 reported clinical trials
13 drugs studied
Affiliated Hospitals
Clinical Trials Samuel Klein, MD is currently running
Weight Loss Strategies
for Obesity
Bariatric surgery markedly improves glycemic control in persons with Type 2 Diabetes (T2D). Roux-en-Y gastric bypass (RYGB), a procedure that bypasses the upper gastrointestinal (UGI) tract, results in greater rates of diabetes resolution compared to methods that leave the UGI tract intact. Studies suggest that mechanisms beyond weight-loss account for the superiority of RYGB compared to other surgical methods. These weight-loss independent metabolic effects may involve increased postprandial production and release of nutrition- responsive hormones. Fibroblast growth factor 21 (FGF21) is a nutrition-adaptive hormone with the potential to alleviate symptoms of diabetes and obesity. Preliminary data therefore suggest that RYGB surgery may alter postprandial FGF21 regulation which could be important for achieving post-meal nutrient homeostasis. Therefore, the goal of this study is to test how nutrient content of the meal affects FGF21 concentrations before and after weight loss induced by RYGB or very low calorie diet (VLCD) therapy. The importance of FGF21 for glucose, insulin, triglyceride, and adipose tissue and muscle metabolism in these two groups will also be tested.
Recruiting1 award N/A2 criteria
Specific Diets
for Obesity
The purposes of this study are: 1) to determine the mechanisms responsible for the development of cardiometabolic complications in some, but not all people with obesity; 2) determine the best dietary approach for cardiometabolic health; and 3) understand why some people have a stable metabolic phenotype over time whereas cardiometabolic health improves or worsens in others.
Recruiting1 award N/A
More about Samuel Klein, MD
Clinical Trial Related7 years of experience running clinical trials · Led 8 trials as a Principal Investigator · 4 Active Clinical TrialsTreatments Samuel Klein, MD has experience with
- Mediterranean Diet
- Ketogenic Diet
- Low-calorie Diet
- Roux-en-Y Gastric Bypass
- Low-carbohydrate, Ketogenic Diet
- Low-fat Diet
Breakdown of trials Samuel Klein, MD has run
Obesity
Severe Weight Loss
Insulin Resistance
Diabetic Retinopathy
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Samuel Klein, MD specialize in?
Samuel Klein, MD focuses on Obesity and Diabetes Mellitus. In particular, much of their work with Obesity has involved treating patients, or patients who are undergoing treatment.
Is Samuel Klein, MD currently recruiting for clinical trials?
Yes, Samuel Klein, MD is currently recruiting for 4 clinical trials in Saint Louis Missouri. If you're interested in participating, you should apply.
Are there any treatments that Samuel Klein, MD has studied deeply?
Yes, Samuel Klein, MD has studied treatments such as Mediterranean diet, Ketogenic Diet, Low-calorie diet.
What is the best way to schedule an appointment with Samuel Klein, MD?
Apply for one of the trials that Samuel Klein, MD is conducting.
What is the office address of Samuel Klein, MD?
The office of Samuel Klein, MD is located at: Washington University School of Medicine, Saint Louis, Missouri 63110 United States. This is the address for their practice at the Washington University School of Medicine.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.