Weight Loss for Lipedema

(Lipedema Trial)

Recruiting in Palo Alto (17 mi)

Overseen by Samuel Klein, MD

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Washington University School of Medicine

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial involves lean and obese women with lipedema following a dietitian-guided weight loss plan. The goal is to see if losing weight can improve fat distribution, overall health, and potentially reduce pain and fat buildup in the legs.

Eligibility Criteria

This trial is for women with lipedema, a condition causing abnormal fat accumulation in the legs. Eligible participants include lean women (BMI between 19.5 and 26) and those with obesity (BMI between 30 and 50), without type 2 diabetes, significant organ dysfunction, or recent cancer. They shouldn't have had bariatric surgery or be on certain medications.

Inclusion Criteria

I am a woman with a BMI between 30 and 50, and have lipedema.

I have been diagnosed with Lipedema.

I am a woman with lipedema and my BMI is between 19.5 and 26.

Exclusion Criteria

I have gone through menopause naturally or due to medical reasons.

I have had weight loss surgery in the past.

My cancer has been in remission for less than 5 years.

Participant Groups

The study investigates how diet-induced weight loss affects body composition, insulin sensitivity, and fat tissue biology in women with lipedema. It involves comprehensive testing against control groups to understand the impact of weight loss as a potential therapy for managing lipedema.

Group I: Women with Obesity and Lipedema Experimental Treatment 1 Intervention

Body composition, adipose tissue biology, insulin sensitivity and immune function/inflammation assessed before and after low-calorie diet therapy to achieve 5-10% weight loss.

Group II: Lean women with Lipedema Experimental Treatment 1 Intervention

Body composition, adipose tissue biology, insulin sensitivity assessed before and after low-calorie diet therapy to achieve 5-10% weight loss.

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Washington University School of Medicine Saint Louis, MO

Who Is Running the Clinical Trial?

Washington University School of Medicine Lead Sponsor

Lipedema Foundation Collaborator

References