Trial Summary
What is the purpose of this trial?The goal of this proposal is to determine whether the beneficial effects of NMN on metabolic function observed in rodents applies to people.
Eligibility Criteria
This trial is for adults with a BMI between 25.0-50.0 kg/m² who have prediabetes, indicated by certain blood sugar levels or insulin resistance scores. It's not open to women who are menstruating, people taking vitamin B3 supplements unless they stop them before and during the study, or those consuming more than two cups of coffee daily unless they can quit without withdrawal symptoms.Inclusion Criteria
You have a body mass index (BMI) between 25 and 34.9.
I have prediabetes based on my glucose tolerance test or HbA1C levels.
Prediabetes defined as fasting plasma glucose of ≥100 mg/dL, or HbA1C ≥5.7, or HOMA-IR ≥2.5.
+1 more
Exclusion Criteria
I drink more than 2 cups of coffee or similar daily or get headaches if I stop.
Unstable weight (>3% change during the last 2 months before entering the study)
I am a woman who still has menstrual periods.
+1 more
Participant Groups
The study is testing if NMN (a compound that might improve metabolic functions) has positive effects on humans as it does in rodents. Participants will either receive NMN supplementation or a placebo to compare outcomes between the treated group and the control group.
2Treatment groups
Experimental Treatment
Placebo Group
Group I: NMN supplementationExperimental Treatment1 Intervention
At least 16 weeks of NMN.
Group II: PlaceboPlacebo Group1 Intervention
At least 16 weeks of placebo.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Washington University School of MedicineSaint Louis, MO
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Who Is Running the Clinical Trial?
Washington University School of MedicineLead Sponsor
United States Department of DefenseCollaborator