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Betamethasone Augmented vs Regular
Introduction
For patients dealing with skin conditions such as eczema, psoriasis or dermatitis, certain corticosteroid medications can help in reducing inflammation and managing symptoms. Betamethasone Augmented and Regular Betamethasone are two such drugs that are often prescribed for these conditions. They both work by suppressing the body's immune response which leads to decreased inflammation.
Regular Betamethasone is a potent corticosteroid that helps reduce swelling, redness, and itching associated with various skin disorders. On the other hand, Betamethasone Augmented has been modified from its regular form to become more potent and have a quicker onset of action. It contains an additional propionate group which enables it to penetrate the skin faster providing quicker relief.
However, due to its increased potency, augmented betamethasone should be used sparingly and under strict medical supervision as long-term use can lead to side effects including skin thinning or hormonal imbalances.
Betamethasone Augmented vs Regular Side By Side
| Attribute | Diprolene af | Celestone betnovate |
|---|---|---|
| Brand Name | Diprolene AF | Celestone, Betnovate |
| Contraindications | Should not be used with certain types of antifungal medications or drugs that suppress the immune system; should not receive live vaccines | Should not be used with certain types of antifungal medications or drugs that suppress the immune system; should not receive live vaccines |
| Cost | Around $300 for a 15 gram tube of 0.05% cream | Around $50 - $100 for a similar quantity and concentration |
| Generic Name | Augmented Betamethasone Dipropionate | Betamethasone |
| Most Serious Side Effect | Adrenal insufficiency, increased blood pressure | Severe headache or dizziness, slow wound healing |
| Severe Drug Interactions | Certain antifungals, immunosuppressants | Certain antifungals, immunosuppressants |
| Typical Dose | Once or twice a day, with specific dosages depending on the condition | Applied in small amounts to the affected area 1-3 times daily, under occlusion if necessary |
What is Betamethasone Augmented?
Betamethasone is a potent corticosteroid used to reduce inflammation in the body, mirroring a major leap forward from earlier less-specific steroids. It received FDA approval in 1961. Betamethasone works by suppressing the immune response, effectively "calming" it down and reducing associated swelling, redness and itchiness. It's often prescribed for various skin conditions like eczema and psoriasis.
There are two versions of this medication available: regular betamethasone and augmented betamethasone (also known as augmented betamethasone dipropionate). The latter is enhanced with propylene glycol to increase its strength and skin penetration ability. While both types function similarly overall, augmented betamethasone typically delivers more potent results due to its increased absorption rate; however, it may also carry a slightly higher risk of side effects compared to regular betamethasome because of this enhanced potency.
What conditions is Betamethasone Augmented approved to treat?
Betamethasone Augmented is approved for the treatment of different types of skin conditions:
- Dermatoses responsive to corticosteroids, such as psoriasis and atopic dermatitis
- Severe hyperkeratotic (scaling) conditions
- Treatment-resistant inflammations of the skin when a more potent topical steroid is needed
How does Betamethasone Augmented help with these illnesses?
Betamethasone, in both its regular and augmented forms, is a powerful corticosteroid that helps reduce inflammation in the body by suppressing the immune system's response to irritants or allergens. It does this by preventing the release of substances that cause inflammation. Betamethasone is commonly used to treat skin conditions such as eczema, dermatitis, allergies, and rash. The key difference between regular betamethasone and augmented betamethasone is the potency. Augmented betamethasone is designed to be more potent, allowing for a stronger and faster response to inflammation. It penetrates the skin more effectively, reaching the cells that are causing the inflammation more efficiently. Therefore, by increasing the potency of the corticosteroid, augmented betamethasone can limit the negative effects of inflammation and help patients manage their skin conditions more effectively.
What is Regular?
Regular Betamethasone, known by various brand names including Celestone and Betnovate, is a corticosteroid that has anti-inflammatory and immunosuppressive properties. It works by reducing inflammation in the body by inhibiting inflammatory responses to stimuli. Regular betamethasone was first approved by the FDA in 1961.
As regular betamethasone does not contain added potency-enhancing agents like its augmented counterpart, it presents a different side effect profile which can be beneficial depending on individual patient characteristics and needs. For instance, regular betamethasone is less likely to cause skin thinning or changes in skin color compared to augmented versions of the drug.
The effects of standard betamethasone can be preferred for patients who require long-term treatment for chronic conditions such as eczema or psoriasis without exacerbating unwanted side-effects.
What conditions is Regular approved to treat?
Regular Betamethasone is an FDA-approved corticosteroid used for a variety of conditions such as:
- Dermatological diseases including severe dermatitis, psoriasis, and eczema
- Allergic states like asthma and allergic rhinitis
- Inflammatory bowel diseases This medication acts by reducing inflammation in the body.
How does Regular help with these illnesses?
Betamethasone, a type of glucocorticoid steroid, exerts powerful anti-inflammatory and immunosuppressive effects. It operates by suppressing the immune response and inflammation in the body, thereby providing relief from symptoms related to conditions like eczema, psoriasis and allergic reactions.
Regular Betamethasone works by controlling the rate at which proteins are made in the body that cause swelling and itchiness. This makes it particularly effective for managing skin conditions that result from an overactive immune system or inflammation. In comparison to its augmented counterpart, regular Betamethasone generally has a lower potency but is still highly effective for many patients. The choice between regular betamethasone and augmented betamethasone may come down to individual patient needs – some people might need a more potent version for severe symptoms or when other treatments have failed; others may find sufficient relief with regular betamethasone.
How effective are both Betamethasone Augmented and Regular?
Both betamethasone and augmented betamethasone have strong anti-inflammatory, immunosuppressive and antipruritic effects. They were both approved by the FDA in the early 1960s for use as topical corticosteroids to treat a variety of skin conditions. Despite having similar active ingredients, they are used under different circumstances due to their formulation differences.
The term "augmented" refers to the presence of a propylene glycol base in the ointment or cream that enhances penetration of the steroid into the skin, leading to increased potency. Therefore, augmented betamethasone is typically prescribed when regular betamethasone has not provided adequate relief or when dealing with particularly thick-skinned areas such as palms and soles where greater penetration is needed.
In terms of safety profile, both forms exhibit potential side effects typical of topical steroids including atrophy (thinning), striae (stretch marks), telangiectasia (visible blood vessels), purpura (bruising) and contact dermatitis. Augmented versions tend to be somewhat more potent which may increase risk for these side effects if used improperly; however they also potentially offer greater symptom relief when stronger treatment is necessary.
A study in 2017 compared effectiveness between regular betamethasone dipropionate lotion versus its augmented version in patients suffering from psoriasis vulgaris. The results showed improved efficacy with augmented preparation but no significant difference was found regarding side effect occurrence rate.
Despite being widely accepted treatments for various dermatological conditions, it's important that these medications are only used under medical supervision due to possible adverse effects related especially with long-term use or over large body areas.
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At what dose is Betamethasone Augmented typically prescribed?
Topical dosages of Betamethasone, both augmented and regular versions, typically range from application once or twice a day. Studies have indicated that once-daily usage is often sufficient for treating various skin conditions in most adults. Children may also use this medication but under strict supervision due to the increased risk of absorption through the skin. In either population, if there is no response after two weeks of consistent use, it should be reviewed by a healthcare professional. The duration and frequency of therapy will depend upon the nature and severity of the condition being treated; however, prolonged continuous topical treatment should be avoided where possible as it increases the potential for local side-effects and systemic absorption.
At what dose is Regular typically prescribed?
Regular Betamethasone treatment typically begins with a dosage that depends on the specific condition being treated and its severity. The dose can then be adjusted based on patient response and tolerance. It is often applied in small amounts to the affected area 1-3 times daily, under occlusion if necessary. For severe or resistant dermatoses, it may require a more liberal application or an increased frequency of application. However, it's crucial not to exceed your doctor's recommended dosage because overuse can lead to side effects such as thinning skin, stretch marks, or systemic absorption leading to hormonal imbalance.
What are the most common side effects for Betamethasone Augmented?
Common side effects of augmented betamethasone compared to regular include:
- Burning, itching, or irritation at the site of application
- Dry skin
- Acne or skin blemishes
- Changes in skin color (usually lighter)
- Increased hair growth on the body or face
- Thinning of the skin leading to easy bruising
- Stretch marks (striae)
- "Pitting" (small depressions in the skin)
In rare cases, it may cause systemic effects such as:
- Weight gain, especially in your face and midsection
- Fatigue or feeling weak
- Muscle weakness
- Depression, anxiety
Remember that you should always contact a healthcare professional if any side effect becomes severe or persistent.
Are there any potential serious side effects for Betamethasone Augmented?
When comparing Betamethasone Augmented and regular Betamethasone, it's important to note that both contain the same active ingredient but in different concentrations. Therefore, the potential side effects are generally similar for both:
- Signs of allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue or throat.
- Skin reactions: redness, burning sensation at application site, itching or rash.
- Vision problems: blurred vision or seeing halos around lights
- Mood changes: sleep problems (insomnia), mood swings, personality changes and feelings of depression.
- Physical symptoms such as fatigue, muscle weakness or loss of appetite.
However with augmented betamethasone which is a more potent version, there could be increased likelihoods for these side effects. Severe issues might include adrenal insufficiency - symptoms may include tiredness that gets worse over time, muscle weakness, loss of appetite and weight loss. In some rare cases there can also be an increase in blood pressure leading to headaches,dizziness and possible fainting spells. If you experience any severe reactions it's imperative you seek immediate medical attention.
What are the most common side effects for Regular?
Regular Betamethasone, as opposed to the augmented version, can lead to side effects such as:
- Dry skin or redness at the application site
- Itching or burning sensations
- Acne-like rash
- Changes in skin color
- Irritation around mouth area
- Allergic contact dermatitis (skin inflammation) These side effects can occur when using regular betamethasone. However, it is worth noting that augmented betamethasone often has a stronger effect and may increase these side effects. Always consult with your healthcare professional before starting any new medication regimen.
Are there any potential serious side effects for Regular?
While Regular Betamethasone is generally safe, it can sometimes lead to severe side effects. Some of these include:
- Signs of an allergic reaction such as difficulty breathing, swelling in your face or throat, hives
- Mood changes, sleep problems, personality changes
- Weight gain especially around the midsection and upper back, along with face puffiness
- Muscle weakness or tiredness
- Skin discoloration (darker or lighter)
- Severe headache or dizziness
- Slow wound healing
If you notice any of these symptoms while using regular Betamethasone, immediately consult a healthcare professional. It's also important to remember that not every individual will experience these side effects; this list merely represents potential reactions some users may have.
Contraindications for Betamethasone Augmented and Regular?
Both regular betamethasone and augmented betamethasone, like most other corticosteroid medications, may cause a variety of side effects. If you notice your symptoms worsening or if new ones appear after starting treatment with either form of this drug, please seek immediate medical attention.
Neither regular nor augmented betamethasone should be used if you are taking certain types of antifungal medications or drugs that suppress the immune system; these can increase your risk for serious infections while using the corticosteroids. Always inform your physician about all current and recent medication use; some medicines will require a period to clear from your system to prevent dangerous interactions with both forms of betamethasone.
Furthermore, patients who have been prescribed any type of corticosteroid should not receive live vaccines due to the immunosuppressive effects these medications may have. It's also worth noting that abrupt discontinuation without gradually tapering off could lead to withdrawal symptoms in individuals who have been on long-term therapy.
How much do Betamethasone Augmented and Regular cost?
For the brand name versions of these drugs:
- The price of a 15 gram tube of Diprolene AF (augmented betamethasone dipropionate) cream (0.05%) averages around $300, which works out to approximately $20/day based on typical usage.
- The price for a similar quantity and concentration of regular Betamethasone cream is about $50 - $100, translating to a cost range from $3.33/day to $6.67/day.
Thus, if you are using an average amount per day, then the brand-name regular Betamethasone is less expensive than its augmented counterpart on a per-day treatment basis.
Please note that cost should not be your primary consideration in determining which version is right for you as both have different potencies and may yield different outcomes depending on your condition's severity.
For their generic versions, costs are significantly lower:
- Generic Augmented betamethasone dipropionate (0.05% cream) tends to cost around $30-$60 for 15 grams ($2-$4/day based on typical usage).
- Regular generic betamethasone valerate at the same concentration can be found costing about half that amount or even less; typically between $10–$25 ($0.66–$1.67 per day).
Popularity of Betamethasone Augmented and Regular
Betamethasone, available in generic form and under various brand names, is a corticosteroid medication used to treat a variety of skin conditions such as eczema and psoriasis. Regular betamethasone was prescribed to an estimated 2 million people in the US in 2020. It accounted for approximately 8% of topical corticosteroid prescriptions in the country.
On the other hand, augmented betamethasone dipropionate is a more potent formulation of this medication. It's designed to have greater anti-inflammatory and vasoconstrictive abilities than regular betamethasone dipropionate. Augmented betamethasone dipropionate was prescribed to about 1.5 million individuals nationwide last year, making up roughly 6% of all topical steroid prescriptions filled within that time frame.
While both forms of the drug are effective for treating inflammatory skin conditions, doctors may choose one over the other based on individual patient needs and severity of symptoms.
Conclusion
Both betamethasone regular and augmented have been widely used for years in managing inflammatory skin conditions like dermatitis, psoriasis, and eczema. They are both glucocorticoids that work by reducing inflammation, redness, itching, and swelling. However, the "augmented" version contains a propylene glycol base which enhances penetration of the betamethasone into the skin thereby making it more potent than its regular counterpart.
Prescription preference between these two versions depends on the severity of symptoms and patient's response to treatment. Betamethasone augmented would usually be considered as initial therapy for severe cases or those who did not respond well to first-line topical corticosteroids such as betamethasone regular.
It is important to note that while both drugs are available in generic form offering cost savings especially for patients paying out-of-pocket, they may also require an adjustment period where effects may not be noticeable immediately upon use.
Both medications share similar side effect profiles with potential risks including thinning of skin (atrophy), stretch marks (striae), rosacea-like rash around mouth (perioral dermatitis) among others but with augmented being potentially more likely to induce these due to its enhanced potency. Patients must closely monitor their skins when starting treatment and should seek medical help immediately if they notice worsening or unusual changes in their condition.
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Refrences
- Ling, M., Gottlieb, A., Pariser, D., Caro, I., Stewart, D., Scott, G., & Abrams, K. (2005, January 1). A randomized study of the safety, absorption and efficacy of pimecrolimus cream 1% applied twice or four times daily in patients with atopic dermatitis. Journal of Dermatological Treatment. Informa UK Limited.http://doi.org/10.1080/09546630510033159
- ENGLISH, J. S. C., BUNKER, C. B., RUTHVEN, K., DOWD, P. M., & GREAVES, M. W. (1989, January). A double-blind comparison of the efficacy of betamethasone dipropionate cream twice daily versus once daily in the treatment of steroid responsive dermatoses. Clinical and Experimental Dermatology. Oxford University Press (OUP).http://doi.org/10.1111/j.1365-2230.1989.tb00879.x