Depression Clinical Trials in Boston
View 54 new treatments for depression near you in Boston, MA. Every day, Power helps over 527 depression patients connect with leading medical research.ALTO-300 for Depression
Alto Neuroscience Clinic, Boston + 3 more
This trial is testing ALTO-300, a new medication, to see if it can make antidepressants work better for patients who are already taking them.
Verified
BI 1569912 for Depression
Boehringer Ingelheim Clinic, Boston + 4 more
This trial tests a new medicine, BI 1569912, for adults with depression who haven't improved with other treatments. Participants take the medicine daily while continuing their usual therapy. The study checks if the new medicine helps reduce depression symptoms.Show More
Verified
TMS for Depression
Research Clinic, Boston + 1 more
The goal of this clinical trial is to test a new brain stimulation treatment target for individuals with depression plus at least one additional psychiatric disorder. The main question is to understand the safety profile of a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation when it is targeting the posterior parietal cortex. Additional questions focus on whether this stimulation improves symptoms of depression and other psychiatric disorders as well as whether this stimulation changes brain function.Show More
No Placebo Trial
Xenon Inhalation Therapy for Depression
Research Clinic, Boston + 1 more
The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression. Specifically, the investigators will conduct a parallel randomized, double-blind crossover study that will compare the effects of xenon-oxygen (35:65 ratio by volume) added to treatment as usual (X-TAU group) to the effects of nitrogen-oxygen (35:65 ratio by volume) added to treatment as usual (N-TAU group). A total of 20 severely depressed patients, 10 with major depressive disorder (MDD) and 10 with Bipolar Depression (BP), will be exposed in random order to N-TAU and X-TAU in a double-blind protocol.Show More
AXS-05 for Depression
Axsome Clinic, Boston + 1 more
This trial is testing AXS-05, a new medication, to see if it can prevent depression from returning in people who have already improved with it. The study focuses on those with major depressive disorder and aims to maintain their balanced brain chemicals to keep them feeling better. AXS-05 (a combination of dextromethorphan and bupropion) has shown positive results in previous trials for major depressive disorder.Show More
No Placebo Trial
Antidepressants for Depression
Research Clinic, Belmont + 1 more
The main goal of this research is to use behavioral, brain, and clinical data to determine which type of antidepressant might be optimal before people with depression start treatment.Show More
No Placebo Trial
Multiple Medications for Bipolar Depression
Research Clinic, Belmont + 2 more
This trial is testing four different medications to find the best treatment for adults with bipolar disorder type 1 who are currently depressed. The medications work by balancing brain chemicals that affect mood. The goal is to help patients recover from depression and stay well.Show More
No Placebo Trial
ECT vs. Ketamine for Depression
Research Clinic, Belmont + 2 more
This trial compares two treatments for patients with severe depression who are at risk of suicide. One treatment uses electric currents to change brain activity, while the other uses a low dose of a fast-acting drug. The goal is to find out which treatment works better for rapid relief. The drug has recently emerged as a fast-acting alternative for patients with treatment-resistant depression.Show More
No Placebo Trial
Brexanolone for Depression in Perimenopausal Women
Research Clinic, Boston + 1 more
This study aims to identify how the progesterone metabolite allopregnanolone affects behavior and neurobiology that may underlie perimenopausal depression.
Ketamine + Esketamine for Depression
Research Clinic, Boston + 1 more
The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large sample of matched historical controls. Patients will be recruited from an inpatient psychiatric unit. Eligible patients who provided informed consent will be enrolled in the study that will include a eight IV ketamine treatments, 13 esketamine treatment visits, seven long assessment visits, five short assessment visits, and daily surveys. The study will examine the feasibility, tolerability, and efficacy of repeated IV ketamine followed by esketamine, as well as predictors of treatment response.Show More
No Placebo Trial
Frequently Asked Questions
How much do depression clinical trials pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range. Further, most trials will cover the costs of an Uber to-and-from the clinic. Factors that can affect compensation include the phase of the trial, the length of the trial, the frequency of visits, and the specific condition being studied.
Do I need to be insured to participate in a medical study?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on Cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
How do depression clinical trials work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll typical be sorted into one of the treatment groups, and will receive your study drug. For some trials, there is a chance you'll receive a placebo. Across depression trials in New York City, 42% of clinical trials have a placebo. Typically you'll be required to check-in with the clinic every month or two. The average trial length in this city for depression patients is 6 Months.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in getting approval for a specific condition. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. Phase 2 trials are those where the drug has some data showing safety in humans, but where effectiveness has typically only been shown in animals and non-human experiments. Phase 1 trials are the trials where we don't have safety data in humans. As a general rule, phase 3 trials are more promising than phase 2, and phase 2 trials are more promising than phase 1.
How many people will have already taken the drug in my study?
This depends on the phase of the trial, as well as the condition. For drugs that are in Phase 3, it's typical that at least 200 many patients will have participated over the first and second phases. For Phase 2, 100 is the typical number of people who will have participated.
Where in New York City is research being conducted?
Manhattan is the most active borough in New York City for clinical trials in depression, with neighborhoods such as the Upper East Side and Midtown hosting major research centers. The top individual hospitals include Memorial Sloan Kettering Cancer Center, Columbia University Medical Center, Icahn School of Medicine at Mount Sinai, and NYU Langone Health, which collectively run the majority of depression clinical trials in the city.
What promising new drugs are being tested?
Many of the drugs being researched near New York City work via glutamate: the main excitatory signal in the brain. Some of these drugs shift how your natural glutamate functions and others, like ketamine, block one of the receptors that glutamate works on. The other common category of drugs being explored are psychedelics, like psilocybin, which are thought to work by helping your brain become more plastic. Other drugs being researched in multiple trials include Aticaprant and BHV-7000.
What non-medication treatments are being researched?
Non-drug treatments for depression being researched in clinical trials in New York City can be categorized into psychotherapy, digital and mobile app-based interventions, brain stimulation techniques like TMS, and educational and training programs. These trials include approaches like Cognitive Behavioral Therapy, mindfulness, family support, symptom education, and neurofeedback.
Why are others applying to these studies?
I have tried two other drugs that didn't have any positive affect on my mental health and am hoping that trying out this trial will help me find a solution.
M.A. Patient
Depression Patient
I've tried many anti-depressants in my 45 year struggle with Major Depression. I'm hoping this study is the 'game changer'
B.E. Patient
Late-Life Depression Patient
I've tried more then 5 drugs for depression and it's very depressing frustrating when they do not work, or even help nothing, I'm still looking for that one or 2 that will help
A.L. Patient
Major Depression Patient