Depression Clinical Trials in Cleveland

View 29 new treatments for depression near you in Cleveland, OH. Every day, Power helps over 527 depression patients connect with leading medical research.

ALTO-300 for Depression

Alto Neuroscience Clinic, Akron + 2 more

This trial is testing ALTO-300, a new medication, to see if it can make antidepressants work better for patients who are already taking them.

Verified

Recruiting
Phase 2
Est. 4 - 6 Weeks
Adam Savitz, MD, PhD
Study Director

Multiple Medications for Bipolar Depression

Research Clinic, Cleveland + 1 more

This trial is testing four different medications to find the best treatment for adults with bipolar disorder type 1 who are currently depressed. The medications work by balancing brain chemicals that affect mood. The goal is to help patients recover from depression and stay well.Show More
Waitlist

No Placebo Trial

Phase 4
Est. 3 - 12 Weeks
Unregistered Study Lead
Research Team

ECT vs. Ketamine for Depression

Research Clinic, Cleveland + 1 more

This trial compares two treatments for patients with severe depression who are at risk of suicide. One treatment uses electric currents to change brain activity, while the other uses a low dose of a fast-acting drug. The goal is to find out which treatment works better for rapid relief. The drug has recently emerged as a fast-acting alternative for patients with treatment-resistant depression.Show More
Waitlist

No Placebo Trial

Phase 4
Est. 3 - 12 Weeks
Amit Anand, MD
Principal Investigator

Seltorexant for Depression

Janssen Clinic, Avon Lake + 1 more

This trial is testing seltorexant to see if it can help people with depression and insomnia who haven't improved with their current antidepressants. Seltorexant aims to improve mood and sleep by acting on certain brain receptors.Show More
Recruiting
Phase 3
Est. 3 - 12 Weeks
Janssen Research & Development, LLC Clinical Trail
Study Director

REL-1017 for Depression

Relmada Clinic, Middleburg Heights + 2 more

This trial tests if adding REL-1017 to current antidepressant treatments can better help people with Major Depressive Disorder. Participants will take their usual antidepressants plus either REL-1017 or another substance. The goal is to see if REL-1017 can improve their depression symptoms. REL-1017 (esmethadone) has shown potential rapid and sustained antidepressant effects in previous trials.Show More
Recruiting
Phase 3
Est. 6 - 12 Weeks
Marco Pappagallo, MD
Study Director

Investigational Drug for Bipolar Depression

Sunovion Clinic, Avon Lake + 2 more

This trial is testing a new medication called SEP-4199 CR to see if it can help adults aged 18-65 who have depression from Bipolar I disorder. The study will compare the effects of the medication to see if it reduces symptoms of depression. SEP-4199 has shown antidepressant efficacy in a previous study for bipolar depression.Show More
Recruiting
Phase 3
Est. 6 - 12 Weeks
CNS Medical Director
Study Chair

Cariprazine for Bipolar Disorder in Youth

AbbVie Clinic, Avon Lake + 1 more

This trial is testing the safety and effectiveness of Cariprazine for treating depressive episodes in children and teenagers with bipolar I disorder. The goal is to find out if Cariprazine can help young people with this condition. Cariprazine is an atypical antipsychotic recently approved for the treatment of depressive episodes in adults with bipolar I disorder.Show More
Recruiting
Phase 3
Est. 6 - 12 Weeks
ALLERGAN INC.
Study Director

Aticaprant for Major Depressive Disorder

Janssen Clinic, Garfield Heights + 1 more

This trial is testing aticaprant to see if it can help people with major depressive disorder who still feel very down and don't enjoy things despite taking other antidepressants. The study focuses on adults who haven't responded well to their current treatments. Aticaprant works by blocking a specific brain receptor, which might help improve their mood and reduce depressive symptoms.Show More
Recruiting
Phase 3
Est. 6 - 12 Weeks
Janssen Research & Development, LLC Clinical Trial
Study Director

Psilocybin for Treatment-Resistant Depression

COMPASS Pathways Clinic, Beachwood + 2 more

This trial is testing a new medication called COMP360 to help people with severe depression that hasn't improved with other treatments. The study involves adults aged 18 and older. Researchers want to see if a single dose of COMP360 can reduce depression symptoms when given with psychological support.Show More
Recruiting
Phase 3
Est. 3 - 6 Weeks
Unregistered Study Lead
Research Team

Lumateperone for Pediatric Bipolar Depression

Intra-Cellular Therapies Clinic, Avon Lake + 2 more

This is a multicenter, randomized, double-blind, placebo-controlled study in pediatric patients who are experiencing major depressive episodes (MDEs) associated with a primary diagnosis of bipolar I or bipolar II disorder as confirmed by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL), according to criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM 5).Show More
Recruiting
Phase 3
Est. 3 - 6 Weeks
Unregistered Study Lead
Research Team
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Frequently Asked Questions

How much do depression clinical trials pay?

Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range. Further, most trials will cover the costs of an Uber to-and-from the clinic. Factors that can affect compensation include the phase of the trial, the length of the trial, the frequency of visits, and the specific condition being studied.

Do I need to be insured to participate in a medical study?

Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on Cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

How do depression clinical trials work?

After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll typical be sorted into one of the treatment groups, and will receive your study drug. For some trials, there is a chance you'll receive a placebo. Across depression trials in New York City, 42% of clinical trials have a placebo. Typically you'll be required to check-in with the clinic every month or two. The average trial length in this city for depression patients is 6 Months.

What does the "phase" of a clinical trial mean?

The phase of a trial reveals what stage the drug is in getting approval for a specific condition. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. Phase 2 trials are those where the drug has some data showing safety in humans, but where effectiveness has typically only been shown in animals and non-human experiments. Phase 1 trials are the trials where we don't have safety data in humans. As a general rule, phase 3 trials are more promising than phase 2, and phase 2 trials are more promising than phase 1.

How many people will have already taken the drug in my study?

This depends on the phase of the trial, as well as the condition. For drugs that are in Phase 3, it's typical that at least 200 many patients will have participated over the first and second phases. For Phase 2, 100 is the typical number of people who will have participated.

Where in New York City is research being conducted?

Manhattan is the most active borough in New York City for clinical trials in depression, with neighborhoods such as the Upper East Side and Midtown hosting major research centers. The top individual hospitals include Memorial Sloan Kettering Cancer Center, Columbia University Medical Center, Icahn School of Medicine at Mount Sinai, and NYU Langone Health, which collectively run the majority of depression clinical trials in the city.

What promising new drugs are being tested?

Many of the drugs being researched near New York City work via glutamate: the main excitatory signal in the brain. Some of these drugs shift how your natural glutamate functions and others, like ketamine, block one of the receptors that glutamate works on. The other common category of drugs being explored are psychedelics, like psilocybin, which are thought to work by helping your brain become more plastic. Other drugs being researched in multiple trials include Aticaprant and BHV-7000.

What non-medication treatments are being researched?

Non-drug treatments for depression being researched in clinical trials in New York City can be categorized into psychotherapy, digital and mobile app-based interventions, brain stimulation techniques like TMS, and educational and training programs. These trials include approaches like Cognitive Behavioral Therapy, mindfulness, family support, symptom education, and neurofeedback.

Why are others applying to these studies?

  • I have tried two other drugs that didn't have any positive affect on my mental health and am hoping that trying out this trial will help me find a solution.

    M.A. Patient

    Depression Patient

  • I've tried many anti-depressants in my 45 year struggle with Major Depression. I'm hoping this study is the 'game changer'

    B.E. Patient

    Late-Life Depression Patient

  • I've tried more then 5 drugs for depression and it's very depressing frustrating when they do not work, or even help nothing, I'm still looking for that one or 2 that will help

    A.L. Patient

    Major Depression Patient