Depression Clinical Trials in Columbus
View 19 new treatments for depression near you in Columbus, OH near me. Every day, Power helps over 527 depression patients connect with leading medical research.ALTO-300 for Depression
Alto Neuroscience Clinic, Columbus + 1 more
This trial is testing ALTO-300, a new medication, to see if it can make antidepressants work better for patients who are already taking them.
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MBCT + IV Ketamine for Depression
Research Clinic, Columbus + 1 more
The purpose of this study is to assess the feasibility of combining IV ketamine, a rapid acting antidepressant, with a course of Mindfulness-Based Cognitive Therapy (MBCT), for the initial and maintenance treatment of depression.Show More
No Placebo Trial
Psilocybin for Major Depressive Disorder - TRD
COMPASS Pathways Clinic, Columbus + 1 more
This trial is testing COMP360, a new treatment for adults who have not responded to other depression treatments. Participants will receive one of three doses of COMP360 along with psychological support. The goal is to see if this combination can help improve their depression symptoms.Show More
No Placebo Trial
NMRA-335140 for Depression
Neumora Clinic, Columbus + 1 more
This trial is testing a new medication called NMRA-335140 to see if it helps people with major depressive disorder. It includes participants who have no safety concerns. The medication aims to improve mood by affecting brain chemicals.Show More
No Placebo Trial
NMRA 335140 for Depression
Neumora Clinic, Columbus + 1 more
This trial is testing a new medication called NMRA 335140 to see if it can help people with Major Depressive Disorder feel less depressed. The study involves an initial evaluation and a treatment phase where participants will receive either the medication or an inactive substance. The medication likely works by changing brain chemicals that affect mood.Show More
Aticaprant for Depression
Janssen Clinic, Columbus + 1 more
This trial is testing if aticaprant can help adults with major depressive disorder who haven't responded well to current antidepressants. The medication works by targeting brain chemicals to improve mood and pleasure.Show More
Lumateperone for Major Depressive Disorder
Intra-Cellular Therapies Clinic, Columbus + 1 more
This trial is testing lumateperone, a medication that may help people with depression who haven't improved with other treatments. The study includes patients diagnosed with Major Depressive Disorder who haven't responded well to their current antidepressants. Lumateperone works by balancing brain chemicals that affect mood, potentially improving depressive symptoms.Show More
Aticaprant for Depression
Janssen Clinic, Columbus + 1 more
This trial is testing if adding aticaprant to current antidepressants is safe and well-tolerated in people with major depressive disorder. The goal is to see if it can help improve their treatment.Show More
No Placebo Trial
Pramipexole vs Escitalopram for Depression in HIV
Research Clinic, Columbus + 1 more
A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with mild neurocognitive disorder (MND) in persons with HIV (PWH). Participants will be assessed comprehensively and briefly at intercurrent visits to monitor for toxicity, response to therapy, and to assess for dose changes. An optional sub-study to evaluate treatment impact on the cerebrospinal fluid (CSF) profile will be conducted in a subset of 36 participants.Show More
No Placebo Trial
RE104 for Postpartum Depression
Reunion Neuroscience Clinic, Columbus + 1 more
This trial is testing whether a single injection of RE104 can help reduce depression in women who have moderate-to-severe postpartum depression. The goal is to see if this treatment works effectively. The exact way RE104 works isn't detailed, but it likely helps by affecting brain chemicals related to mood.Show More
No Placebo Trial
Frequently Asked Questions
How much do depression clinical trials pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range. Further, most trials will cover the costs of an Uber to-and-from the clinic. Factors that can affect compensation include the phase of the trial, the length of the trial, the frequency of visits, and the specific condition being studied.
Do I need to be insured to participate in a medical study?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on Cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
How do depression clinical trials work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll typical be sorted into one of the treatment groups, and will receive your study drug. For some trials, there is a chance you'll receive a placebo. Across depression trials in Columbus, 42% of clinical trials have a placebo. Typically you'll be required to check-in with the clinic every month or two. The average trial length in this city for depression patients is 6 Months.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in getting approval for a specific condition. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. Phase 2 trials are those where the drug has some data showing safety in humans, but where effectiveness has typically only been shown in animals and non-human experiments. Phase 1 trials are the trials where we don't have safety data in humans. As a general rule, phase 3 trials are more promising than phase 2, and phase 2 trials are more promising than phase 1.
Where in Columbus is research being conducted for depression?
Prominent hospitals in Columbus conducting clinical trials for depression include The Ohio State University and Nationwide Children's Hospital. Approximately 11 trials are ongoing as of 2023, primarily centered around the university area.
What promising new drugs are being tested?
In Columbus, research for depression includes treatments like Cognitive-behavioral skills building and Psychedelic Therapy. Specific interventions such as Psilocybin, Seltorexant, and Vagus Nerve Stimulation are also being explored.
Why are others applying to these studies?
I have tried two other drugs that didn't have any positive affect on my mental health and am hoping that trying out this trial will help me find a solution.
M.A. Patient
Depression Patient
I've tried many anti-depressants in my 45 year struggle with Major Depression. I'm hoping this study is the 'game changer'
B.E. Patient
Late-Life Depression Patient
I've tried more then 5 drugs for depression and it's very depressing frustrating when they do not work, or even help nothing, I'm still looking for that one or 2 that will help
A.L. Patient
Major Depression Patient