Depression Clinical Trials in Orlando
View 62 new treatments for depression near you in Orlando, FL. Every day, Power helps over 527 depression patients connect with leading medical research.REL-1017 for Depression
Relmada Clinic, Maitland + 4 more
This trial tests if adding REL-1017 to current antidepressant treatments can better help people with Major Depressive Disorder. Participants will take their usual antidepressants plus either REL-1017 or another substance. The goal is to see if REL-1017 can improve their depression symptoms. REL-1017 (esmethadone) has shown potential rapid and sustained antidepressant effects in previous trials.Show More
Verified
Aticaprant for Depression
Janssen Clinic, Maitland + 4 more
This trial is testing aticaprant to see if it can help adults with major depressive disorder and anhedonia who haven't responded well to other antidepressants. Aticaprant works by blocking certain receptors in the brain to potentially improve depressive symptoms.Show More
Verified
ALTO-300 for Depression
Alto Neuroscience Clinic, Clermont + 4 more
This trial is testing ALTO-300, a new medication, to see if it can make antidepressants work better for patients who are already taking them.
Verified
AXS-05 for Depression
Axsome Clinic, Orlando + 1 more
This trial is testing AXS-05, a new medication, to see if it can prevent depression from returning in people who have already improved with it. The study focuses on those with major depressive disorder and aims to maintain their balanced brain chemicals to keep them feeling better. AXS-05 (a combination of dextromethorphan and bupropion) has shown positive results in previous trials for major depressive disorder.Show More
No Placebo Trial
Psilocybin for Depression
Research Clinic, Orlando + 1 more
This trial is testing psilocybin, a substance from mushrooms, to see if it can help adults with depression who may not respond well to current treatments. Psilocybin works by affecting brain chemicals related to mood. Psilocybin has shown promise as a treatment for major depressive disorder and was designated as a breakthrough therapy by the FDA in 2019.Show More
Lumateperone for Depression
Intra-Cellular Therapies Clinic, Orlando + 1 more
This is a multicenter, open-label, fixed dose, 26 week study of patients with MDD. Eligible patients from the lead-in studies will enter the Open-label Safety Study at the Screening/Baseline Visit (Visit 1/Day 1), at which point patient eligibility will be assessed and informed consent obtained.Show More
No Placebo Trial
Investigational Drug for Bipolar Depression
Sunovion Clinic, Clermont + 2 more
This trial is testing a new medication called SEP-4199 CR to see if it can help adults aged 18-65 who have depression from Bipolar I disorder. The study will compare the effects of the medication to see if it reduces symptoms of depression. SEP-4199 has shown antidepressant efficacy in a previous study for bipolar depression.Show More
Cariprazine for Bipolar Disorder in Youth
AbbVie Clinic, Orange City + 1 more
This trial is testing the safety and effectiveness of Cariprazine for treating depressive episodes in children and teenagers with bipolar I disorder. The goal is to find out if Cariprazine can help young people with this condition. Cariprazine is an atypical antipsychotic recently approved for the treatment of depressive episodes in adults with bipolar I disorder.Show More
Aticaprant for Major Depressive Disorder
Janssen Clinic, Orange City + 2 more
This trial is testing aticaprant to see if it can help people with major depressive disorder who still feel very down and don't enjoy things despite taking other antidepressants. The study focuses on adults who haven't responded well to their current treatments. Aticaprant works by blocking a specific brain receptor, which might help improve their mood and reduce depressive symptoms.Show More
Psilocybin for Treatment-Resistant Depression
COMPASS Pathways Clinic, Orlando + 2 more
This trial is testing a new medication called COMP360 to help people with severe depression that hasn't improved with other treatments. The study involves adults aged 18 and older. Researchers want to see if a single dose of COMP360 can reduce depression symptoms when given with psychological support.Show More
Frequently Asked Questions
How much do depression clinical trials pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range. Further, most trials will cover the costs of an Uber to-and-from the clinic. Factors that can affect compensation include the phase of the trial, the length of the trial, the frequency of visits, and the specific condition being studied.
Do I need to be insured to participate in a medical study?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on Cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
How do depression clinical trials work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll typical be sorted into one of the treatment groups, and will receive your study drug. For some trials, there is a chance you'll receive a placebo. Across depression trials in New York City, 42% of clinical trials have a placebo. Typically you'll be required to check-in with the clinic every month or two. The average trial length in this city for depression patients is 6 Months.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in getting approval for a specific condition. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. Phase 2 trials are those where the drug has some data showing safety in humans, but where effectiveness has typically only been shown in animals and non-human experiments. Phase 1 trials are the trials where we don't have safety data in humans. As a general rule, phase 3 trials are more promising than phase 2, and phase 2 trials are more promising than phase 1.
How many people will have already taken the drug in my study?
This depends on the phase of the trial, as well as the condition. For drugs that are in Phase 3, it's typical that at least 200 many patients will have participated over the first and second phases. For Phase 2, 100 is the typical number of people who will have participated.
Where in New York City is research being conducted?
Manhattan is the most active borough in New York City for clinical trials in depression, with neighborhoods such as the Upper East Side and Midtown hosting major research centers. The top individual hospitals include Memorial Sloan Kettering Cancer Center, Columbia University Medical Center, Icahn School of Medicine at Mount Sinai, and NYU Langone Health, which collectively run the majority of depression clinical trials in the city.
What promising new drugs are being tested?
Many of the drugs being researched near New York City work via glutamate: the main excitatory signal in the brain. Some of these drugs shift how your natural glutamate functions and others, like ketamine, block one of the receptors that glutamate works on. The other common category of drugs being explored are psychedelics, like psilocybin, which are thought to work by helping your brain become more plastic. Other drugs being researched in multiple trials include Aticaprant and BHV-7000.
What non-medication treatments are being researched?
Non-drug treatments for depression being researched in clinical trials in New York City can be categorized into psychotherapy, digital and mobile app-based interventions, brain stimulation techniques like TMS, and educational and training programs. These trials include approaches like Cognitive Behavioral Therapy, mindfulness, family support, symptom education, and neurofeedback.
Why are others applying to these studies?
I have tried two other drugs that didn't have any positive affect on my mental health and am hoping that trying out this trial will help me find a solution.
M.A. Patient
Depression Patient
I've tried many anti-depressants in my 45 year struggle with Major Depression. I'm hoping this study is the 'game changer'
B.E. Patient
Late-Life Depression Patient
I've tried more then 5 drugs for depression and it's very depressing frustrating when they do not work, or even help nothing, I'm still looking for that one or 2 that will help
A.L. Patient
Major Depression Patient