Diabetes Clinical Trials in San Antonio
View 122 new treatments for Diabetes in San Antonio, TX. Every day, Power helps hundreds of Diabetes patients connect with leading medical research.Filter Results
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INV 202 for Diabetic Kidney Disease
Inversago Clinic, San Antonio + 1 more
This trial tests a new drug called INV-202 in adults with Diabetic Kidney Disease caused by Type 1 or Type 2 diabetes. The goal is to see if the drug is effective, safe, and well-tolerated, and how it behaves in the body.Show More
Verified
Recruiting
Phase 2
Est. 5 - 8 Weeks
Glenn Crater, MD
Study Director
SGLT2 Inhibitors for Heart Failure
Research Clinic, San Antonio + 2 more
This trial uses empagliflozin to help people with Type 2 Diabetes and Heart Failure. The medication increases blood ketone levels, which may improve muscle and heart function, exercise capacity, and overall well-being. Empagliflozin has been shown to reduce cardiovascular death and hospitalization for heart failure in patients with type 2 diabetes.Show More
Recruiting
Phase < 1
Est. 6 - 12 Weeks
Carolina Solis-Herrera, MD
Principal Investigator
Oral Ketones for Heart Failure
Research Clinic, San Antonio + 1 more
This study will provide insight into whether cardiac function changes with oral Ketone Esters (KE) administered to patients with Type 2 Diabetes Mellitus (T2DM) and Heart failure with reduced ejection fraction (HFrEF). Plasma ketones are avidly extracted by cardiac muscle and their uptake is not dependent upon insulin or influenced by insulin resistance.Show More
Recruiting
No Placebo Trial
Phase < 1
Est. 3 - 6 Weeks
Carolina Solis-Herrera, MD
Principal Investigator
Empagliflozin for Type 2 Diabetes
Research Clinic, San Antonio + 1 more
In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and type 1 diabetes (T1D), and that the increases in ketone production and lipolysis can be prevented by concomitant administration of the thiazolidinedione pioglitazone. We will conduct five distinct experiments to test this hypothesis in patients with T2D and T1D. STUDY 1: To examine the effect of empagliflozin versus empagliflozin/pancreatic clamp on EGP (6,6, D2-glucose), gluconeogenesis (D2O), lipolysis (U-2H-glycerol), ketogenesis (13C-palmitate conversion to 3-betahydroxybuyrate), and norepinephrine turnover (3H-NE) in type 2 diabetes subjects. STUDY 2. To examine the role of the SNS on the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D by comparing the effect of empagliflozin versus empagliflozin plus propranolol. STUDY 3. To examine the 2-HIT hypothesis that the SGLT2i-induced stimulation of EGP, lipolysis, and ketone production requires the combination of volume depletion plus insulinopenia in T2D individuals. STUDY 4. To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects). STUDY 5. To examine whether the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T1D individuals can be blocked by pioglitazone (which has direct hepatic and adipose tissue effects).Show More
Recruiting
Phase < 1
Est. 3 - 12 Weeks
Ralph DeFronzo, MD
Principal Investigator
Acipimox + Empagliflozin for Heart Failure and Type 2 Diabetes
Research Clinic, San Antonio + 1 more
The study team will examine the effects of elevated plasma ketone levels following initiation of SGLT2 inhibitor therapy in high-risk type 2 diabetes mellitus (T2DM) individuals with heart failure (HF) with reduced ejection fraction (HFrEF) providing an energy-rich fuel that is taken up with great avidity by the myocardium, to measure change in Left Ventricle diastolic and systolic functionShow More
Recruiting
Phase < 1
Est. 4 - 6 Weeks
Ralph DeFronzo, MD
Principal Investigator
ILUVIEN® Implant for Diabetic Macular Edema
Alimera Sciences Clinic, San Antonio + 1 more
This is a randomized, masked, active-controlled, parallel-group, multi-center study that will assess the efficacy of ILUVIEN as a baseline therapy in the treatment of Center Involving DME (CI-DME). The study will enroll patients who are either treatment naïve or have not received any DME treatments for the preceding 12 months as documented in medical records. Patients who received DME treatment \>12 months before screening, must not have received \>4 intravitreal injections. The study will compare 2 treatment regimens: ILUVIEN intravitreal implant (0.19 mg) followed by supplemental aflibercept as needed per protocol criteria (2 mg/0.05 mL), compared to intravitreal aflibercept loading dose (2 mg administered by intravitreal injection every 4 weeks for 5 consecutive doses) followed by supplemental aflibercept as needed per protocol criteria (2 mg/0.05 mL).Show More
Waitlist
No Placebo Trial
Phase 4
Est. 5 - 8 Weeks
Samer Kaba, MD
Study Chair
Dapagliflozin + Pioglitazone for Type 1 Diabetes
Research Clinic, San Antonio + 1 more
Purpose: To examine the effect of addition of combination therapy with dapagliflozin plus pioglitazone to insulin on glucose control and plasma ketone concentration in patients with type 1 diabetes (T1DM) Research Design: 120 patients with type 1 diabetes who otherwise are healthy constitute the study population. After screening, eligible subjects will start 4 week run in. At week 4, subjects will receive dapagliflozin for 12 weeks. At week 16, subjects will be randomized to receive in a double blind fashion pioglitazone or placebo for 16 weeks. Methods: the following techniques will be employed in the present study: (1) mixed meal tolerance test; (2) indirect calorimetry; (3) continuous glucose monitoring. Clinical Relevance: the results of the present study will demonstrate that the addition of pioglitazone to SGLT2 inhibitor in T1DM patients produces greater reduction in the HbA1c without increasing risk of ketoacidosis and hypoglycemia.Show More
Recruiting
Phase 4
Est. 3 - 12 Weeks
Unregistered Study Lead
Research Team
Faricimab for Diabetic Macular Edema
Research Clinic, San Antonio + 1 more
This study will assess a pragmatic, treat and extend regimen of faricimab against the standard of a fixed dosing regimen.
Recruiting
No Placebo Trial
Phase 4
Est. 3 - 6 Weeks
Dr. Varun Chaudhary, MD, FRCS(C)
Principal Investigator
A Study of Tirzepatide (LY3298176) in Adults With Type 2 Diabetes Switching From a GLP-1 RA (SURPASS-SWITCH-2)
Eli Lilly Clinic, Shavano Park + 1 more
This trial is testing a new medication called tirzepatide for people with type 2 diabetes. Tirzepatide helps control blood sugar by making the body produce more insulin and reducing appetite. The study aims to see if switching to this new treatment is more effective than current therapies.Show More
Waitlist
No Placebo Trial
Phase 4
Est. 4 - 6 Weeks
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Study Director
Pioglitazone for Fatty Liver Disease
Research Clinic, San Antonio + 2 more
This trial studies the effects of pioglitazone, a medication that helps the body use insulin more effectively, in patients with type 2 diabetes who have liver conditions like NAFL or NASH. Pioglitazone is a safe and effective option to manage patients with type 2 diabetes and nonalcoholic steatohepatitis (NASH). The goal is to see if this treatment can improve liver function and control blood sugar levels. Researchers will measure various aspects of liver metabolism and insulin sensitivity before and after a few months of treatment.Show More
Recruiting
Phase 4
Est. 5 - 8 Weeks
Luke Norton, PhD
Principal Investigator
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