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Exparel for Post-Surgery Pain Management in Thyroid Conditions

Phase < 1
Waitlist Available
Led By Tabitha Galloway, MD
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients requiring parathyroid/thyroid surgery based on the standard of care
Be older than 18 years old
Must not have
Patients under the age of 18 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after surgery, patients will be monitored for two weeks, until they return for their first postoperative appointment.
Awards & highlights
Approved for 20 Other Conditions
All Individual Drugs Already Approved
No Placebo-Only Group

Summary

This trial is testing whether a medication called Exparel can decrease the amount of opioids needed for pain control after surgery.

Who is the study for?
This trial is for English-speaking adults over 18 who need thyroid or parathyroid surgery. It's not open to those under 18, with a history of opioid abuse, or allergies to local anesthetics or opioids.
What is being tested?
The study tests if Exparel, when injected during surgery, reduces the need for opioid painkillers after thyroid and parathyroid surgeries. It aims to improve postoperative pain management.
What are the potential side effects?
Possible side effects may include reactions at the injection site such as swelling and redness, nerve damage symptoms like numbness or tingling, allergic reactions, and low blood pressure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I need surgery for my parathyroid or thyroid as recommended by my doctor.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am under 18 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after surgery, patients will be monitored for two weeks, until they return for their first postoperative appointment.
This trial's timeline: 3 weeks for screening, Varies for treatment, and after surgery, patients will be monitored for two weeks, until they return for their first postoperative appointment. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Incidence of opioid use when given Exparel intraoperatively

Awards & Highlights

Approved for 20 Other Conditions
This treatment demonstrated efficacy for 20 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Exparel InjectionExperimental Treatment1 Intervention
Thyroid and parathyroid surgery with local injection of lidocaine and epinephrine preincison and Exparel postincision
Group II: Bupivicaine HCLExperimental Treatment1 Intervention
Thyroid or parathyroid surgery with local injection of bupivicaine HCL and Epinephrine preincision.
Group III: Current PracticeActive Control1 Intervention
Thyroid or parathyroid surgery with local injection of lidocaine and epinephrine preincision, as is current practice.

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
379 Previous Clinical Trials
628,482 Total Patients Enrolled
Tabitha Galloway, MDPrincipal InvestigatorUniversity of Missouri Department of Otolaryngology-Head and Neck Surgery

Media Library

Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine Clinical Trial Eligibility Overview. Trial Name: NCT04085913 — Phase < 1
Parathyroid Adenomas Research Study Groups: Exparel Injection, Bupivicaine HCL, Current Practice
Parathyroid Adenomas Clinical Trial 2023: Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine Highlights & Side Effects. Trial Name: NCT04085913 — Phase < 1
Lidocaine Epinephrine, Bupivacaine Hydrochloride-EPINEPHrine 2023 Treatment Timeline for Medical Study. Trial Name: NCT04085913 — Phase < 1
~16 spots leftby Dec 2025