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Behavioral Intervention

Attention Bias Modification for Depression

Phase < 1

Waitlist Available

Led By Christopher G Beevers, Ph.D

Research Sponsored by University of Texas at Austin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, weeks 1-4 (acute period), weeks 12-28 (follow-up period)

Summary

This trial aims to compare two different treatments for depression in adults. The first aim is to see if a gamified treatment is more effective than a sham treatment. The second aim is to show that gam

Who is the study for?

This trial is for adults with symptoms of depression. Participants will be asked to fill out questionnaires, do eye-tracking tasks, and undergo interviews by clinicians. Details on specific inclusion or exclusion criteria are not provided.

What is being tested?

The study tests two types of Attention Bias Modification (ABM) treatments: a gamified version and the traditional one, against a sham (inactive) treatment. It aims to see which ABM method is more effective at improving depression symptoms and how long the effects last.

What are the potential side effects?

Potential side effects are not specified in this summary but generally, ABM interventions have minimal risks as they involve computer-based tasks designed to train attention patterns.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, weeks 1-4 (acute period), weeks 12-28 (follow-up period)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, weeks 1-4 (acute period), weeks 12-28 (follow-up period)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, weeks 1-4 (acute period), weeks 12-28 (follow-up period) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

QIDS (Quick Inventory of Depression Symptoms) SR-16

Secondary study objectives

Generalized Anxiety Disorder (GAD-7)

Hamilton Depression Rating Scale (HAM-D)

Perseverative Thinking Questionnaire (PTQ)

+2 more

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Gamified Attention Bias ModificationExperimental Treatment1 Intervention

This ABM variant will be completed on participants' mobile devices (iOS or Android). During app use, they will be presented with sad-happy stimulus pairs followed by target probes (tracing a path) always appearing at the happy stimulus location.

Group II: Traditional Attention Bias ModificationActive Control1 Intervention

This ABM variant is a web-based program delivered to participants via a computer. It presents pairs of stimuli to the right and left visual fields from two stimulus categories: sad or neutral facial expressions from the Pictures of Facial Affect (POFA) collection and dysphoric or neutral scenes from or from the International Affective Picture System (IAPS) collection.

Group III: Sham Attention Bias ModificationPlacebo Group1 Intervention

Sham and traditional ABM interventions will be identical in all respects with one critical exception. For sham ABM, after stimuli offset the target will appear with equal probability (50%) in the location of the neutral or the dysphoric stimulus.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Gamified Attention Bias Modification

2023

N/A

~110

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