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Neuroimaging for Chronic Fatigue Syndrome

Phase < 1

Waitlist Available

Led By Eric M Wassermann, M.D.

Research Sponsored by National Institute of Neurological Disorders and Stroke (NINDS)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Healthy Controls: Male or female, aged 18-50

ME/CFS Patients: Male or female, aged 18-50

Must not have

Healthy Controls: Current major neurological or psychiatric disorders

Healthy Controls: Current use of medications acting primarily on the central nervous system

Timeline

Screening 3 weeks

Treatment Varies

Follow Up the measurement will be assessed concurrently with physical effort stimulus administration during the fmri associated with one of the study visits, 1-31 days following the visit for the first session.

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to understand how the brain processes different unpleasant sensations in people with chronic pain conditions like ME/CFS. Participants will undergo three visits where they will experience mild heat and physical exertion tasks while

Who is the study for?

This trial is for people aged 18 to 50 who have ME/CFS or are healthy volunteers. It involves three visits over a few weeks, where participants will undergo MRI scans and perform tasks that measure their response to pain from heat and the effort of squeezing a bar.

What is being tested?

The study aims to understand how the brain processes unpleasant sensations like pain from mild to moderate heat (thermal pain) and physical exertion (effort). Participants' responses during these activities will be monitored through MRI scans and muscle function tests.

What are the potential side effects?

There may not be direct side effects from participating in this trial as it does not involve medication or invasive procedures. However, some individuals might find lying still in an MRI scanner uncomfortable or experience discomfort from the thermal pain stimulation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 50 years old and healthy.

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I am between 18 and 50 years old and have ME/CFS.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I do not have any major neurological or psychiatric disorders.

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I am currently taking medication that affects my brain or nerves.

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I have ME/CFS without other major medical conditions.

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I do not have conditions affecting my grip or limbs.

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I have ME/CFS but no major neurological or psychiatric conditions.

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I am currently taking medication for attention, psychosis, or anxiety.

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I have used opioids for more than two weeks in the past two years or recently.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ the measurement will be assessed concurrently with physical effort stimulus administration during the fmri associated with one of the study visits, 1-31 days following the visit for the first session.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~the measurement will be assessed concurrently with physical effort stimulus administration during the fmri associated with one of the study visits, 1-31 days following the visit for the first session.

This trial's timeline: 3 weeks for screening, Varies for treatment, and the measurement will be assessed concurrently with physical effort stimulus administration during the fmri associated with one of the study visits, 1-31 days following the visit for the first session. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Determine which regions of the SVN are specifically involved in the subjective experience of unpleasantness associated with sensations of pain.

Determine which regions of the SVN are specifically involved in the subjective experience of unpleasantness associated with sensations of physical effort.