Urinary Tract Infection > Lactobacillus Reuteri RC-14 And Lactobacillus Rhamnosus GR-1
~1 spots leftby Apr 2026

Bacteriuria Eradication Through Probiotics

(BERP Trial)

Recruiting in Palo Alto (17 mi)
EA
Overseen byEric A Jones, M.D.
Age: < 65
Sex: Female
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Phase 1
Waitlist Available
Sponsor: Baylor College of Medicine
No Placebo Group

Trial Summary

What is the purpose of this trial?

Many children who catheterize their bladders because of spina bifida or other neurologic disorders have bacteriuria. This can lead to urinary tract infections by bacteria from the gut which colonize the vagina and are carried into the bladder during catheter passage. We seek to test whether oral administration of probiotic bacteria can "displace" these vagina-derived uropathogens and reduce or prevent bacteriuria in girls with spina bifida who empty their bladders through catheterization.

Research Team

EA

Eric A Jones, M.D.

Principal Investigator

Texas Children's Hospital, Baylor College of Medicine

Eligibility Criteria

Inclusion Criteria

Eligible subjects are girls (age 3 months to 18 years) with spina bifida as a sole urologic diagnosis
perform clean intermittent catheterization because of neurogenic bladder.
Secondary vesicoureteral reflux is permissible.
See 1 more

Treatment Details

Interventions

  • Lactobacillus reuteri RC-14 and Lactobacillus rhamnosus GR-1 (Probiotic)
Participant Groups
1Treatment groups
Experimental Treatment
Group I: 1Experimental Treatment1 Intervention
Oral probiotics

Find a Clinic Near You

Research Locations NearbySelect from list below to view details:
Texas Children's HospitalHouston, TX
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Who Is Running the Clinical Trial?

Baylor College of Medicine

Lead Sponsor

Trials
1044
Patients Recruited
6,031,000+

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Collaborator

Trials
678
Patients Recruited
421,000+

London Health Sciences Centre OR Lawson Research Institute of St. Joseph's

Collaborator

Trials
668
Patients Recruited
424,000+

London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's

Collaborator

Trials
686
Patients Recruited
427,000+

Chr Hansen

Industry Sponsor

Trials
33
Patients Recruited
4,600+

Lawson Health Research Institute

Collaborator

Trials
684
Patients Recruited
432,000+
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