PET/MRI with [18F]FTC-146 for Chronic Pain

Recruiting in Palo Alto (17 mi)

Overseen byAnand Veeravagu, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Recruiting

Sponsor: Stanford University

No Placebo Group

Trial Summary

What is the purpose of this trial?

This trial uses a special imaging dye and advanced scans to find out where chronic pain is coming from in the body. It includes people with different types of chronic pain and healthy volunteers. The dye helps highlight pain-related areas in the scans, aiding in better diagnosis and treatment.

Research Team

Anand Veeravagu, MD

Principal Investigator

Stanford University Department of Neurosurgery

Eligibility Criteria

This trial is for adults over 18, both healthy and those with chronic pain lasting more than 2 months. Participants can be vaccinated or unvaccinated but must test negative for Covid within 72 hours of the scan. People who are pregnant, nursing, claustrophobic, non-English speakers, on pain medication (healthy volunteers), or incompatible with MRI cannot join.

Inclusion Criteria

I have been experiencing chronic pain for more than 2 months.

My pain level is at least 4 out of 10.

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Exclusion Criteria

Healthy Volunteers: Pregnant or nursing

If you don't speak English, you cannot participate as a healthy volunteer.

I do not speak English.

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Treatment Details

Interventions

[18F]FTC-146 (Sigma-1 Receptor Agonist)

Trial Overview[18F]FTC-146 and PET/MRI technology are being tested to identify the source of chronic pain by comparing its uptake in healthy individuals versus those with chronic pain. The study aims to understand how sigma-1 receptors contribute to chronic pain conditions.

Participant Groups

2Treatment groups

Experimental Treatment

Group I: Pain PatientsExperimental Treatment1 Intervention

Individuals suffering from nociceptive pain, neuropathic pain, and mixed pain (pain that appears to be both nociceptive and neuropathic) and undergo a \[18F\]FTC-146 PET/MRI scan.

Group II: Healthy VolunteersExperimental Treatment1 Intervention

Individuals who do not have pain and undergo a \[18F\]FTC-146 PET/MRI scan.